- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT01098630
Patient, Physician, and Nurse Factors Associated With Entry Onto Clinical Trials and Finishing Treatment in Patients With Primary or Recurrent Uterine, Endometrial, or Cervical Cancer
Patient, Physician And Nurse Factors Associated With Entry Onto Clinical Trials And Completion Of Treatment For Women With Primary Or Recurrent Invasive Cancer Of The Uterine Corpus Or Uterine Cervix, All Stages
Study Overview
Status
Conditions
- Recurrent Uterine Corpus Sarcoma
- Recurrent Uterine Corpus Carcinoma
- Stage I Uterine Corpus Cancer
- Stage II Uterine Corpus Cancer
- Stage III Uterine Corpus Cancer
- Stage IV Uterine Corpus Cancer
- Recurrent Cervical Carcinoma
- Stage III Uterine Sarcoma
- Stage IV Uterine Sarcoma
- Stage I Uterine Sarcoma
- Stage II Uterine Sarcoma
- Stage IA Cervical Cancer
- Stage IB Cervical Cancer
- Stage IIA Cervical Cancer
- Stage IIB Cervical Cancer
- Stage III Cervical Cancer
- Stage IVA Cervical Cancer
- Stage IVB Cervical Cancer
Intervention / Treatment
Detailed Description
PRIMARY OBJECTIVES:
I. To determine if there are specific, modifiable factors relative to patients, physicians, nurses, or clinical trial designs that predict enrollment or non-enrollment onto a GOG therapeutic trial for patients with primary or recurrent invasive cancer of the uterine corpus or cervix.
II. To determine if the Functional Comorbidity Index is an independent predictor of enrollment in a GOG clinical trial and if it correlates with performance status.
SECONDARY OBJECTIVES:
I. To determine, through multivariate analyses, whether the distribution of patients into a GOG clinical trial entry status categories (i.e., enrolled, not enrolled but eligible, not eligible) varies by demographics or economic status of patients, by patients' beliefs/concerns and interactions with physicians/family and friends, or by nurses' or physicians' beliefs/concerns and interactions with patients.
II. To determine whether patients' beliefs/concerns or interactions are associated with patient, nurse, or physician demographics.
III. To determine whether physicians' beliefs/concerns or interactions are associated with patient or physician demographics.
IV. To perform descriptive analysis regarding factors associated with completion of treatment through analysis of the Treatment Review Form.
OUTLINE: This is a multicenter study. Patients are assigned to 1 of 2 groups.
GROUP I (limited participation): Patients do not complete any questionnaires at baseline.
GROUP II (full participation): Patients complete the Patient Registration Survey and Patient Questionnaire at baseline.
At baseline, patients' medical record information is collected; sites complete the Functional Comorbidity Index; and physicians, nurses, and study coordinators complete the follow-up questionnaire. Staff complete the treatment review form after treatment or 7 months after study registration.
Study Type
Enrollment (Actual)
Contacts and Locations
Study Locations
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Arizona
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Phoenix, Arizona, United States, 85012
- Gynecologic Oncology Group of Arizona
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Tucson, Arizona, United States, 85719
- University of Arizona Cancer Center-North Campus
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California
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Burbank, California, United States, 91505
- Providence Saint Joseph Medical Center/Disney Family Cancer Center
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Burbank, California, United States, 91505
- Roy and Patricia Disney Family Cancer Center
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Concord, California, United States, 94520
- John Muir Medical Center-Concord Campus
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San Diego, California, United States, 92103
- University of California San Diego
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Walnut Creek, California, United States, 94598
- John Muir Medical Center-Walnut Creek
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Connecticut
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Hartford, Connecticut, United States, 06105
- Smilow Cancer Hospital Care Center at Saint Francis
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New Britain, Connecticut, United States, 06050
- The Hospital of Central Connecticut
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Florida
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Orlando, Florida, United States, 32803
- Florida Hospital Orlando
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Hawaii
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Honolulu, Hawaii, United States, 96813
- Queen's Medical Center
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Honolulu, Hawaii, United States, 96813
- University of Hawaii Cancer Center
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Honolulu, Hawaii, United States, 96826
- Kapiolani Medical Center for Women and Children
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Idaho
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Boise, Idaho, United States, 83706
- Saint Alphonsus Cancer Care Center-Boise
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Illinois
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Oak Lawn, Illinois, United States, 60453-2699
- Advocate Christ Medical Center
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Indiana
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Elkhart, Indiana, United States, 46515
- Elkhart General Hospital
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Elkhart, Indiana, United States, 46514
- Michiana Hematology Oncology PC-Elkhart
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Elkhart, Indiana, United States, 46514-2098
- Elkhart Clinic
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Kokomo, Indiana, United States, 46904
- Community Howard Regional Health
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La Porte, Indiana, United States, 46350
- IU Health La Porte Hospital
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Mishawaka, Indiana, United States, 46545
- Michiana Hematology Oncology PC-Mishawaka
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Mishawaka, Indiana, United States, 46545
- Saint Joseph Regional Medical Center-Mishawaka
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Plymouth, Indiana, United States, 46563
- Michiana Hematology Oncology PC-Plymouth
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South Bend, Indiana, United States, 46601
- Memorial Hospital of South Bend
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South Bend, Indiana, United States, 46601
- Michiana Hematology Oncology PC-South Bend
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South Bend, Indiana, United States, 46628
- Northern Indiana Cancer Research Consortium
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Westville, Indiana, United States, 46391
- Michiana Hematology Oncology PC-Westville
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Iowa
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Clive, Iowa, United States, 50325
- Mercy Cancer Center-West Lakes
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Clive, Iowa, United States, 50325
- Medical Oncology and Hematology Associates-West Des Moines
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Des Moines, Iowa, United States, 50309
- Iowa Methodist Medical Center
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Des Moines, Iowa, United States, 50314
- Mercy Medical Center - Des Moines
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Des Moines, Iowa, United States, 50309
- Medical Oncology and Hematology Associates-Des Moines
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Des Moines, Iowa, United States, 50316
- Iowa Lutheran Hospital
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Des Moines, Iowa, United States, 50309
- Iowa-Wide Oncology Research Coalition NCORP
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Des Moines, Iowa, United States, 50314
- Medical Oncology and Hematology Associates-Laurel
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West Des Moines, Iowa, United States, 50266-7700
- Methodist West Hospital
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West Des Moines, Iowa, United States, 50266
- Mercy Medical Center-West Lakes
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Kansas
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Anthony, Kansas, United States, 67003
- Hospital District Sixth of Harper County
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Chanute, Kansas, United States, 66720
- Cancer Center of Kansas - Chanute
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Dodge City, Kansas, United States, 67801
- Cancer Center of Kansas - Dodge City
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El Dorado, Kansas, United States, 67042
- Cancer Center of Kansas - El Dorado
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Fort Scott, Kansas, United States, 66701
- Cancer Center of Kansas - Fort Scott
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Independence, Kansas, United States, 67301
- Cancer Center of Kansas-Independence
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Kingman, Kansas, United States, 67068
- Cancer Center of Kansas-Kingman
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Lawrence, Kansas, United States, 66044
- Lawrence Memorial Hospital
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Liberal, Kansas, United States, 67905
- Cancer Center of Kansas-Liberal
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McPherson, Kansas, United States, 67460
- Cancer Center of Kansas - McPherson
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Newton, Kansas, United States, 67114
- Cancer Center of Kansas - Newton
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Parsons, Kansas, United States, 67357
- Cancer Center of Kansas - Parsons
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Pratt, Kansas, United States, 67124
- Cancer Center of Kansas - Pratt
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Salina, Kansas, United States, 67401
- Cancer Center of Kansas - Salina
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Wellington, Kansas, United States, 67152
- Cancer Center of Kansas - Wellington
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Wichita, Kansas, United States, 67208
- Cancer Center of Kansas-Wichita Medical Arts Tower
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Wichita, Kansas, United States, 67214
- Cancer Center of Kansas - Wichita
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Wichita, Kansas, United States, 67208
- Associates In Womens Health
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Wichita, Kansas, United States, 67214
- Wichita NCI Community Oncology Research Program
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Wichita, Kansas, United States, 67214
- Via Christi Regional Medical Center
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Winfield, Kansas, United States, 67156
- Cancer Center of Kansas - Winfield
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Kentucky
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Louisville, Kentucky, United States, 40202
- Norton Hospital Pavilion and Medical Campus
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Massachusetts
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Springfield, Massachusetts, United States, 01199
- Baystate Medical Center
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Michigan
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Ann Arbor, Michigan, United States, 48106-0995
- Saint Joseph Mercy Hospital
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Ann Arbor, Michigan, United States, 48106
- Michigan Cancer Research Consortium NCORP
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Battle Creek, Michigan, United States, 49017
- Bronson Battle Creek
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Big Rapids, Michigan, United States, 49307
- Spectrum Health Big Rapids Hospital
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Dearborn, Michigan, United States, 48124
- Beaumont Hospital-Dearborn
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Detroit, Michigan, United States, 48236
- Saint John Hospital and Medical Center
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Escanaba, Michigan, United States, 49829
- Green Bay Oncology - Escanaba
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Flint, Michigan, United States, 48502
- Hurley Medical Center
-
Flint, Michigan, United States, 48532
- Genesys Regional Medical Center-West Flint Campus
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Grand Rapids, Michigan, United States, 49503
- Spectrum Health at Butterworth Campus
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Grand Rapids, Michigan, United States, 49503
- Mercy Health Saint Mary's
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Grand Rapids, Michigan, United States, 49503
- Cancer Research Consortium of West Michigan NCORP
-
Iron Mountain, Michigan, United States, 49801
- Green Bay Oncology - Iron Mountain
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Jackson, Michigan, United States, 49201
- Allegiance Health
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Kalamazoo, Michigan, United States, 49007
- West Michigan Cancer Center
-
Kalamazoo, Michigan, United States, 49007
- Bronson Methodist Hospital
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Kalamazoo, Michigan, United States, 49001
- Borgess Medical Center
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Lansing, Michigan, United States, 48912
- Sparrow Hospital
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Livonia, Michigan, United States, 48154
- Saint Mary Mercy Hospital
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Muskegon, Michigan, United States, 49444
- Mercy Health Mercy Campus
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Niles, Michigan, United States, 49120
- Michiana Hematology Oncology PC-Niles
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Pontiac, Michigan, United States, 48341
- Saint Joseph Mercy Oakland
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Port Huron, Michigan, United States, 48060
- Saint Joseph Mercy Port Huron
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Saginaw, Michigan, United States, 48601
- Saint Mary's of Michigan
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Saint Joseph, Michigan, United States, 49085
- Marie Yeager Cancer Center
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Saint Joseph, Michigan, United States, 49085
- Lakeland Hospital
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Traverse City, Michigan, United States, 49684
- Munson Medical Center
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Warren, Michigan, United States, 48093
- Saint John Macomb-Oakland Hospital
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Wyoming, Michigan, United States, 49519
- Metro Health Hospital
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Minnesota
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Burnsville, Minnesota, United States, 55337
- Fairview Ridges Hospital
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Coon Rapids, Minnesota, United States, 55433
- Mercy Hospital
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Edina, Minnesota, United States, 55435
- Fairview-Southdale Hospital
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Fridley, Minnesota, United States, 55432
- Unity Hospital
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Hutchinson, Minnesota, United States, 55350
- Hutchinson Area Health Care
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Maplewood, Minnesota, United States, 55109
- Saint John's Hospital - Healtheast
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Maplewood, Minnesota, United States, 55109
- Minnesota Oncology Hematology PA-Maplewood
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Minneapolis, Minnesota, United States, 55415
- Hennepin County Medical Center
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Minneapolis, Minnesota, United States, 55407
- Abbott-Northwestern Hospital
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Robbinsdale, Minnesota, United States, 55422
- North Memorial Medical Health Center
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Saint Louis Park, Minnesota, United States, 55416
- Park Nicollet Clinic - Saint Louis Park
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Saint Louis Park, Minnesota, United States, 55416
- Metro Minnesota Community Oncology Research Consortium
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Saint Paul, Minnesota, United States, 55101
- Regions Hospital
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Saint Paul, Minnesota, United States, 55102
- United Hospital
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Shakopee, Minnesota, United States, 55379
- Saint Francis Regional Medical Center
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Stillwater, Minnesota, United States, 55082
- Lakeview Hospital
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Waconia, Minnesota, United States, 55387
- Ridgeview Medical Center
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Willmar, Minnesota, United States, 56201
- Rice Memorial Hospital
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Woodbury, Minnesota, United States, 55125
- Minnesota Oncology and Hematology PA-Woodbury
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Mississippi
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Jackson, Mississippi, United States, 39216
- Saint Dominic-Jackson Memorial Hospital
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Pascagoula, Mississippi, United States, 39581
- Singing River Hospital
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Missouri
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Rolla, Missouri, United States, 65401
- Phelps County Regional Medical Center
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Saint Louis, Missouri, United States, 63110
- Washington University School of Medicine
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Springfield, Missouri, United States, 65804
- Cancer Research for the Ozarks NCORP
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Springfield, Missouri, United States, 65807
- CoxHealth South Hospital
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Springfield, Missouri, United States, 65804
- Mercy Hospital Springfield
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Nevada
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Las Vegas, Nevada, United States, 89169
- Women's Cancer Center of Nevada
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New Jersey
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Newark, New Jersey, United States, 07101
- Rutgers New Jersey Medical School
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New York
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Brooklyn, New York, United States, 11203
- State University of New York Downstate Medical Center
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Buffalo, New York, United States, 14263
- Roswell Park Cancer Institute
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Stony Brook, New York, United States, 11794
- Stony Brook University Medical Center
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North Carolina
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Chapel Hill, North Carolina, United States, 27599
- UNC Lineberger Comprehensive Cancer Center
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Durham, North Carolina, United States, 27710
- Duke University Medical Center
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Winston-Salem, North Carolina, United States, 27104
- Southeast Clinical Oncology Research (SCOR) Consortium NCORP
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Ohio
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Akron, Ohio, United States, 44304
- Summa Akron City Hospital/Cooper Cancer Center
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Akron, Ohio, United States, 44307
- Akron General Medical Center
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Canton, Ohio, United States, 44710
- Aultman Health Foundation
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Cleveland, Ohio, United States, 44106
- Case Western Reserve University
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Columbus, Ohio, United States, 43214
- Riverside Methodist Hospital
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Mentor, Ohio, United States, 44060
- Lake University Ireland Cancer Center
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Oklahoma
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Oklahoma City, Oklahoma, United States, 73104
- University of Oklahoma Health Sciences Center
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Tulsa, Oklahoma, United States, 74146
- Oklahoma Cancer Specialists and Research Institute-Tulsa
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Pennsylvania
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Abington, Pennsylvania, United States, 19001
- Abington Memorial Hospital
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Bryn Mawr, Pennsylvania, United States, 19010
- Bryn Mawr Hospital
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Danville, Pennsylvania, United States, 17822
- Geisinger Medical Center
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Hazleton, Pennsylvania, United States, 18201
- Geisinger Medical Center-Cancer Center Hazleton
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Paoli, Pennsylvania, United States, 19301
- Paoli Memorial Hospital
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Philadelphia, Pennsylvania, United States, 19103
- Gynecologic Oncology Group
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State College, Pennsylvania, United States, 16801
- Geisinger Medical Group
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Wilkes-Barre, Pennsylvania, United States, 18711
- Geisinger Wyoming Valley/Henry Cancer Center
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Wynnewood, Pennsylvania, United States, 19096
- Lankenau Medical Center
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Wynnewood, Pennsylvania, United States, 19096
- Main Line Health NCORP
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Rhode Island
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Providence, Rhode Island, United States, 02905
- Women and Infants Hospital
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South Carolina
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Anderson, South Carolina, United States, 29621
- AnMed Health Cancer Center
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Anderson, South Carolina, United States, 29621
- AnMed Health Hospital
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Greenville, South Carolina, United States, 29605
- Greenville Health System Cancer Institute-Faris
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Greenville, South Carolina, United States, 29615
- Greenville Health System Cancer Institute-Eastside
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Seneca, South Carolina, United States, 29672
- Greenville Health System Cancer Institute-Seneca
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Spartanburg, South Carolina, United States, 29303
- Spartanburg Medical Center
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Spartanburg, South Carolina, United States, 29307
- Greenville Health System Cancer Institute-Spartanburg
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South Dakota
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Sioux Falls, South Dakota, United States, 57117-5134
- Sanford USD Medical Center - Sioux Falls
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Sioux Falls, South Dakota, United States, 57104
- Sanford Cancer Center-Oncology Clinic
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Texas
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Houston, Texas, United States, 77030
- The Methodist Hospital System
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Temple, Texas, United States, 76508
- Scott and White Memorial Hospital
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Virginia
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Charlottesville, Virginia, United States, 22908
- University of Virginia Cancer Center
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Wisconsin
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Green Bay, Wisconsin, United States, 54301
- Saint Vincent Hospital
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Green Bay, Wisconsin, United States, 54303
- Green Bay Oncology Limited at Saint Mary's Hospital
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Green Bay, Wisconsin, United States, 54303
- Saint Mary's Hospital
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Green Bay, Wisconsin, United States, 54301-3526
- Green Bay Oncology at Saint Vincent Hospital
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Madison, Wisconsin, United States, 53792
- University of Wisconsin Hospital and Clinics
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Manitowoc, Wisconsin, United States, 54221
- Holy Family Memorial Hospital
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Marinette, Wisconsin, United States, 54143
- Bay Area Medical Center
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Mukwonago, Wisconsin, United States, 53149
- D N Greenwald Center
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Oconomowoc, Wisconsin, United States, 53066
- Oconomowoc Memorial Hospital-ProHealth Care Inc
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Oconto Falls, Wisconsin, United States, 54154
- Green Bay Oncology - Oconto Falls
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Sturgeon Bay, Wisconsin, United States, 54235-1495
- Door County Cancer Center
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Sturgeon Bay, Wisconsin, United States, 54235
- Green Bay Oncology - Sturgeon Bay
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Waukesha, Wisconsin, United States, 53188
- Waukesha Memorial Hospital
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
- Child
- Adult
- Older Adult
Accepts Healthy Volunteers
Genders Eligible for Study
Sampling Method
Study Population
Description
Inclusion Criteria:
Meets 1 of the following criteria:
Patients with a pathologically confirmed diagnosis of a primary or recurrent invasive cancer of the uterine cervix or uterine corpus (all stages)
- Further treatment is indicated
- Treatment must take place at the GOG institution in which the patient is enrolled
- A GOG physician, nurse, or study coordinator for one of the patients described above
- Any GOG performance status
Meets 1 of the following criteria:
Willing and able to complete or be assisted with completion of 2 questionnaires and have limited medical history, treatment details, and demographic data collected
- Patients do not have to speak and write English (can be assisted by an interpreter)
- Willing to have limited medical history, treatment details, and demographic data collected (Patient)
- No patients who refuse treatment
No concurrent treatment in a GOG treatment trial
- Prior participation in a GOG treatment trial allowed
Study Plan
How is the study designed?
Design Details
Cohorts and Interventions
Group / Cohort |
Intervention / Treatment |
---|---|
Group I (limited participation)
Patients do not complete any questionnaires at baseline.
At baseline, patients' medical record information is collected; sites complete the Functional Comorbidity Index; and physicians, nurses, and study coordinators complete the follow-up questionnaire.
Staff complete the treatment review form after treatment or 7 months after study registration.
|
Ancillary studies
Patients' medical record information is collected and staff complete the treatment review form
Other Names:
|
Group II (full participation)
Patients complete the Patient Registration Survey and Patient Questionnaire at baseline.
At baseline, patients' medical record information is collected; sites complete the Functional Comorbidity Index; and physicians, nurses, and study coordinators complete the follow-up questionnaire.
Staff complete the treatment review form after treatment or 7 months after study registration.
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Predictive value of modifiable patient, physician, or clinical trial specific factors on enrollment or non-enrollment onto a treatment clinical trial
Time Frame: 7 months
|
Two-sided Mann-Whitney U-tests will be performed.
|
7 months
|
Predictive value of the Functional Comorbidity Index on whether a patient is enrolled in a clinical trial
Time Frame: 7 months
|
A logistic regression model analysis will be used.
|
7 months
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Enrollment status
Time Frame: 7 months
|
Will be analyzed using categorical variable modeling methods.
Logistic response functions will be used.
|
7 months
|
Patient/physician demographics
Time Frame: 7 months
|
Logistic regression analyses for ordinal categorical outcomes with more than two categories will be used to test the association of patient/physician responses with patient/physician demographics.
All tests will be two-sided likelihood ration Chi-Square tests.
|
7 months
|
Collaborators and Investigators
Sponsor
Collaborators
Investigators
- Principal Investigator: Sandra Brooks, Gynecologic Oncology Group
Publications and helpful links
Study record dates
Study Major Dates
Study Start
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
- Pathologic Processes
- Neoplasms, Connective and Soft Tissue
- Neoplasms by Histologic Type
- Neoplasms
- Urogenital Neoplasms
- Neoplasms by Site
- Neoplasms, Glandular and Epithelial
- Uterine Neoplasms
- Genital Neoplasms, Female
- Uterine Cervical Diseases
- Uterine Diseases
- Disease Attributes
- Sarcoma
- Uterine Cervical Neoplasms
- Carcinoma
- Recurrence
Other Study ID Numbers
- GOG-0247 (Other Identifier: CTEP)
- U10CA101165 (U.S. NIH Grant/Contract)
- NCI-2011-02033 (Registry Identifier: CTRP (Clinical Trial Reporting Program))
- CDR0000668836
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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