The Relationship Between Dietary Habit and Gastroesophageal Flap Valve Abnormality

Gastroesophageal reflux disease (GERD) is commonly seen in Western countries; however, it is gaining prevalence in Asia countries recently. In addition to the lower esophageal sphincter and the crural fibers of the diaphragm, the flap valve at the gastroesophageal junction is also responsible for maintaining an antireflux barrier. Hill et al developed a grading system of gastroesophageal flap valve (GEFV) and concluded that this flap valve system is simple, reproducible, and offers diagnostic aid in the evaluation of patients with suspicious reflux disease undergoing esophagogastroduodenoscopy (EGD). It is a common belief that large meals provoke considerable postprandial reflux and it results from an increase in the rate of transient lower esophageal sphincter relaxations. One study also revealed that rapid food intake produces more gastroesophageal reflux in healthy volunteers. So this study attempted to evaluate the relationship between dietary habit and GEFV abnormality. The investigators used a questionnaire regarding the dietary habit to the population undergoing EGD in a self-paid health examination.

Study Overview

• Status: Unknown
• Conditions: Healthy Subjects

• Study Type: Observational
• Enrollment (Anticipated): 600

Contacts and Locations

Study Locations

• Taiwan
  • Taipei, Taiwan, 116
    • Recruiting
    • Yung-Fa Chen
    • Contact: Yung FA Chen, MD; Phone Number: 8862968718572; Email: brother.fa@sn.tpemail.net.tw

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Child; Adult; Older Adult
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Probability Sample

Study Population

healthy subjects

Description

Inclusion Criteria:

• The healthy subjects undergo EGD in a self-paid health examination in WanFang Hospital.

Exclusion Criteria:

• None

Study Plan

How is the study designed?

Design Details

• Observational Models: Cohort
• Time Perspectives: Prospective

Number of groups / cohorts

1

Cohorts and Interventions

Group / Cohort
population undergoing EGD in health examination.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
Grading of Gastroesophageal Flap Valve by Esophagoduodenoscopy	1 year
Dietary habit questionnaire	1 year

Collaborators and Investigators

• Sponsor: Taipei Medical University WanFang Hospital
• Investigators: Principal Investigator: Yung-Fa Chen, M.D., Taipei Medical University WanFang Hospital

Study record dates

Study Major Dates

• Study Start: August 1, 2010
• Primary Completion (Anticipated): July 1, 2011
• Study Completion (Anticipated): December 1, 2011

Study Registration Dates

• First Submitted: August 10, 2010
• First Submitted That Met QC Criteria: September 1, 2010
• First Posted (Estimate): September 3, 2010

Study Record Updates

• Last Update Posted (Estimate): March 8, 2011
• Last Update Submitted That Met QC Criteria: March 6, 2011
• Last Verified: March 1, 2011

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Congenital Abnormalities
• Other Study ID Numbers: 99033