The Effects of Vibration on Hypoxia

The purpose of this study is:

1. To study the effect of whole-body vibration on partial pressure of oxygen in arterial blood (PaO2), under hypobaric hypoxic conditions.
2. To study the effects of whole-body vibration and hypobaric hypoxia on visual contrast sensitivity.
3. To se if there is an increase in cytokines and other biomarkers under different hypobaric hypoxic conditions Our main hypothesis is that whole-body vibration may cause PaO2 to drop to a lower level, at a given altitude; than would be the case if there were no vibration present.

Study Overview

• Status: Completed
• Conditions: Hypoxia
• Intervention / Treatment: Other: Vibration

• Study Type: Interventional
• Enrollment (Actual): 13
• Phase: Not Applicable

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Child; Adult; Older Adult
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

Description

Inclusion Criteria:

Exclusion Criteria:

• Stay at altitude over 2000 m last two weeks prior to study-start.
• Severe head injury
• Cardiovascular disease
• lung disease
• Decompression sickness

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Basic Science
• Interventional Model: Crossover Assignment
• Masking: Single

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
PaO2	Assessed at six different altitudes	14 minutes
PaO2	Assessed at six dfferent altitudes	35 minutes

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Ventilation	Assessed at six different altitudes, over a period of three minutes.	14 minutes
Ventilation	Assessed over a periode of three minutes, at six different altitudes.	35 minutes

Collaborators and Investigators

• Sponsor: Institute of Aviation Medicine, Oslo, Norway
• Investigators: Principal Investigator: Tor A Hansen, Msc., Institute of Aviation Medicine

Study record dates

Study Major Dates

• Study Start: October 1, 2010
• Primary Completion (Actual): December 1, 2010
• Study Completion (Actual): December 1, 2010

Study Registration Dates

• First Submitted: November 19, 2010
• First Submitted That Met QC Criteria: November 19, 2010
• First Posted (Estimate): November 22, 2010

Study Record Updates

• Last Update Posted (Estimate): January 14, 2011
• Last Update Submitted That Met QC Criteria: January 13, 2011
• Last Verified: January 1, 2011

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Signs and Symptoms, Respiratory; Hypoxia
• Other Study ID Numbers: REK-2010/2021b

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No
• product manufactured in and exported from the U.S.: No