Chinese Herb Nephropathy Epidemiology and Association With CYP2D6, CYP2C19, PXR, or MDR1 Polymorphism

November 12, 2012 updated by: National Taiwan University Hospital

Epidemiology of Chinese Herb Nephropathy and Its Association With CYP2D6, CYP2C19, PXR, or MDR1 Polymorphism

  1. Chinese herb nephropathy (CHN), a kind of kidney failure caused by Chinese herbs, may be related to the a component called aristolochic acid (AA).
  2. AA may form AA-DNA adducts and accumulate in the kidney and ureter and cause kidney failure and/or cancer
  3. Different enzymes have been reported to detoxify plant alkaloids or other components. Genes that regulate the production of these metabolic enzymes may affect the chance of CHN.
  4. By comparing the differences in the polymorphisms of these genes between patient with CHN and control, we may find the changes that play a significant genetic factors for CHN.

Study Overview

Status

Unknown

Conditions

Study Type

Observational

Enrollment (Anticipated)

200

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Contact Backup

  • Name: Kwan-Dun Wu, MD, Ph.D.
  • Phone Number: 5014 +886-2-23123456
  • Email: kdw@ntumc.org

Study Locations

  • Taiwan
      • Taipei, Taiwan, 10051
        • Recruiting
        • National Taiwan University Hospital
        • Contact:
          • Kwan-Dun Wu, MD, PhD
          • Phone Number: 5014 +886-2-23123456
          • Email: kdw@ntumc.org
        • Principal Investigator:
          • Fe-Lin L Wu, Ph.D.
    • Taipei
      • Pan-Chiao, Taipei, Taiwan, 22060
        • Not yet recruiting
        • Far Estern Memorial Hospital

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Child
  • Adult
  • Older Adult

Accepts Healthy Volunteers

Yes

Genders Eligible for Study

All

Sampling Method

Probability Sample

Study Population

People who use Chinese herb

Description

Inclusion Criteria:

  • Patient with suspected Chinese herb nephropathy, and their family Control group match for sex age and geographic area (with or without herabla use)

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

National Taiwan University Hospital

Collaborators

Department of Health, Executive Yuan, R.O.C. (Taiwan)

Investigators

  • Study Chair: Kwan-Dun Wu, MD, PhD, National Taiwan University Hospital

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

May 1, 2006

Study Registration Dates

First Submitted

January 2, 2012

First Submitted That Met QC Criteria

January 3, 2012

First Posted (Estimate)

January 4, 2012

Study Record Updates

Last Update Posted (Estimate)

November 14, 2012

Last Update Submitted That Met QC Criteria

November 12, 2012

Last Verified

January 1, 2012

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 9461701139
  • 95D010

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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