- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT01877447
Comparison of Two tDCS Protocols for the Treatment of Major Depressive Disorder
December 13, 2013 updated by: Andre Brunoni, University of Sao Paulo
Comparison of Two Transcranial Direct Current Stimulation (tDCS) Protocols for the Treatment of Major Depressive Disorder: a Randomized, Double-blinded, Controlled Clinical Trial.
Transcranial direct cranial stimulation (tDCS) is a novel technique based on the application of a weak electrical current over the scalp through two electrodes - the anode, which facilitates neuronal depolarization, and the cathode, which leads to neuronal hyper-polarization.
Recently, several open-label and sham-controlled clinical trials applied daily tDCS sessions for the treatment of major depressive disorder (MDD).
Theoretically, tDCS displays depression improvement through anodal stimulation over the left dorsolateral prefrontal, inducing excitability-enhancing effects over this area, which is hypoactive during the acute depressive episode.
The present study is aimed at comparing two different tDCS protocols: (1) active anodic stimulation over left dorsolateral prefrontal cortex with cathode placed over an extra cephalic area; (2) active cathode placed over the right dorsolateral prefrontal cortex with anode placed over an extra cephalic area.
Study Overview
Status
Completed
Conditions
Intervention / Treatment
Detailed Description
The present research protocol will evaluate clinical effects of two different tDCS protocols: (1) active anodic stimulation over left dorsolateral prefrontal cortex with cathode placed over an extra cephalic area; (2) active cathode placed over the right dorsolateral prefrontal cortex with anode placed over an extra cephalic area.
Patients will be clinically evaluated with the Diagnostic and Statistical Manual of Mental Disorders Fourth Edition (DSM-IV) criteria for depression.
Symptoms intensity will be rated according to The Hamilton Depression Scale (HAMD -17 items) - main outcome.
Patients with scores higher than 16 will be included.
Patients with active neurological or severe disorders (such as cancer or auto-imune disorders) will be excluded.
The present study is a double-blinded, controlled, randomized trial with 30 patients with depression.
The intervention protocol consist in 15 consecutive daily tDCS sessions (skipping the weekend).
After meeting eligibility criteria, patients will be randomized (computer generated list) to one of the two intervention groups.
We will use a direct current of 2.0 milliamperes (mA) for 30 min.
The 35 cm2-rubber electrodes will be wrapped in cotton material, which should be moistened with saline as to reduce impedance.
Patients will be clinically assessed at baseline and at end of 6 weeks.
Main outcome will be based on HAMD-17 items at a final endpoint of 6-weeks, with secondary outcomes assessing Beck Depression Inventory (21 items) at 6 weeks.
Other evaluation scales include Beck Anxiety Inventory, Hamilton Anxiety Scale and Safety and cognitive assessment will be performed with The Montreal Cognitive Assessment, adverse effects scales and clinical evaluation with a trained physician.
Study Type
Interventional
Enrollment (Actual)
30
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
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Sao Paulo, Brazil, 05508000
- Hospital Universitário - USP
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-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years to 89 years (Adult, Older Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Description
Inclusion Criteria:
- patients with age between 18-89 years, depression diagnosis according to Diagnostic and Statistical Manual of Mental Disorders Fourth Edition (DSM-iV); HAMD scores higher than 16; accordance to inform consent
Exclusion Criteria:
- active neurologic or severe disorder (such as cancer or auto-imune)
- pregnancy;
- need for hospitalization
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Double
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: cathodal F4
Transcranial Direct Current Stimulation Cathodal tDCS over F4 (right dorsolateral prefrontal cortex) Anodal tDCS over the left deltoid (extra-cephalic) n=15 |
Current Stimulation with cathodal stimulation over right dorsolateral prefrontal cortex.
Anodal stimulation over left deltoid region
Other Names:
|
Experimental: Anodal F3
Transcranial Direct Current Stimulation' Anodal tDCS over F3 (right dorsolateral prefrontal cortex) Cathodal tDCS over the right deltoid (extra-cephalic) n=15 |
Current Stimulation with cathodal stimulation over right dorsolateral prefrontal cortex.
Anodal stimulation over left deltoid region
Other Names:
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Hamilton Rating Scale for Depression, 17 items (HAMD17)
Time Frame: Weeks 0, 3 and 6
|
reduction of depressive symptoms as assessed by HAMD17
|
Weeks 0, 3 and 6
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Montgomery-Asberg Depression Rating Scale (MADRS)
Time Frame: Weeks 0, 3 and 6
|
reduction of depressive symptoms as assessed by MADRS
|
Weeks 0, 3 and 6
|
Beck Depression Inventory (BDI)
Time Frame: Weeks 0, 3 and 6
|
reduction of depressive symptoms as assessed by BDI
|
Weeks 0, 3 and 6
|
Beck Anxiety Inventory (BAI)
Time Frame: Weeks 0, 3 and 6
|
reduction of anxiety symptoms as assessed by BAI
|
Weeks 0, 3 and 6
|
Hamilton Anxiety Inventory (HAI)
Time Frame: Weeks 0, 3 and 6
|
reduction of anxiety symptoms as assessed by HAI
|
Weeks 0, 3 and 6
|
The Montreal Cognitive Assessment (Moca)
Time Frame: Weeks 0 and 6
|
evaluate cognitive stability as assessed by Moca
|
Weeks 0 and 6
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Investigators
- Principal Investigator: Andre R Brunoni, PhD, Center of Clinical Research - Hospital Universitário USP; Sao Paulo; Brazil
Publications and helpful links
The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.
General Publications
- Kalu UG, Sexton CE, Loo CK, Ebmeier KP. Transcranial direct current stimulation in the treatment of major depression: a meta-analysis. Psychol Med. 2012 Sep;42(9):1791-800. doi: 10.1017/S0033291711003059. Epub 2012 Jan 12.
- Brunoni AR, Ferrucci R, Fregni F, Boggio PS, Priori A. Transcranial direct current stimulation for the treatment of major depressive disorder: a summary of preclinical, clinical and translational findings. Prog Neuropsychopharmacol Biol Psychiatry. 2012 Oct 1;39(1):9-16. doi: 10.1016/j.pnpbp.2012.05.016. Epub 2012 May 28.
- Brunoni AR, Kemp AH, Shiozawa P, Cordeiro Q, Valiengo LC, Goulart AC, Coprerski B, Lotufo PA, Brunoni D, Perez AB, Fregni F, Bensenor IM. Impact of 5-HTTLPR and BDNF polymorphisms on response to sertraline versus transcranial direct current stimulation: implications for the serotonergic system. Eur Neuropsychopharmacol. 2013 Nov;23(11):1530-40. doi: 10.1016/j.euroneuro.2013.03.009. Epub 2013 Apr 21.
- Brunoni AR, Valiengo L, Baccaro A, Zanao TA, de Oliveira JF, Goulart A, Boggio PS, Lotufo PA, Bensenor IM, Fregni F. The sertraline vs. electrical current therapy for treating depression clinical study: results from a factorial, randomized, controlled trial. JAMA Psychiatry. 2013 Apr;70(4):383-91. doi: 10.1001/2013.jamapsychiatry.32.
- Brunoni AR, Benute GR, Fraguas R, Santos NO, Francisco RP, de Lucia MC, Zugaib M. The self-rated Inventory of Depressive Symptomatology for screening prenatal depression. Int J Gynaecol Obstet. 2013 Jun;121(3):243-6. doi: 10.1016/j.ijgo.2013.01.011. Epub 2013 Mar 15.
- Brunoni AR, Ferrucci R, Bortolomasi M, Vergari M, Tadini L, Boggio PS, Giacopuzzi M, Barbieri S, Priori A. Transcranial direct current stimulation (tDCS) in unipolar vs. bipolar depressive disorder. Prog Neuropsychopharmacol Biol Psychiatry. 2011 Jan 15;35(1):96-101. doi: 10.1016/j.pnpbp.2010.09.010. Epub 2010 Sep 18.
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
July 1, 2013
Primary Completion (Actual)
October 1, 2013
Study Completion (Actual)
November 1, 2013
Study Registration Dates
First Submitted
May 24, 2013
First Submitted That Met QC Criteria
June 10, 2013
First Posted (Estimate)
June 13, 2013
Study Record Updates
Last Update Posted (Estimate)
December 16, 2013
Last Update Submitted That Met QC Criteria
December 13, 2013
Last Verified
December 1, 2013
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- aF3_cF4_F32
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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