Auditory Verbal Hallucinations in Schizophrenia (HAV)

Electromyography Study of Lip Muscles During Auditory Verbal Hallucinations Without Subvocalization in Patients With Schizophrenia

Auditory verbal hallucinations (AVHs) are speech perceptions in the absence of a relevant external stimulation. Some accounts of AVHs claim that a deficit in inner speech monitoring would cause the verbal thoughts of the patient to be perceived as external voices resulting in AVHs.

In order to examine whether AVHs correspond to self-generated inner speech, the present study aims at collecting speech muscle activity during covert AVHs (without articulation), overt speech and rest. Surface electromyography (sEMG) is used on schizophrenia patients and control subjects to detect any speech muscle activity during AVH.

Study Overview

• Status: Completed
• Conditions: Schizophrenia

• Study Type: Observational
• Enrollment (Actual): 40

Contacts and Locations

Study Locations

• France
  • Grenoble, France, 38043
    • University hospital of Grenoble

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 60 years (Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

in- and out-patients

Description

Inclusion Criteria:

Healthy controls:

• must be more than 18 years and less than 60 years old
• pre-inclusion medical examination
• must have signed consent form
• must be able to read stimuli on a screen

Schizophrenia patients:

• must be more than 18 years and less than 60 years old
• pre-inclusion medical examination
• must have signed consent form
• must be able to read stimuli on a screen
• diagnosed with a schizophrenia disorder according to DSM-IV TR (diagnostic and statistical of mental disorders) (PANSS item P3 greater than 4)
• prior evaluation of the secondary effects of any medication via Barnes and AIMS scales
• affiliated with the French social security
• if under guardianship, must have additional consent form signed by guardian

Exclusion Criteria:

Healthy controls:

• if aged less than 18 years or more than 60 years
• diagnosed with any psychiatric disorder
• with any language disorder (aphasia, SLI, dysarthria, stuttering, etc.)
• with auditory impairment
• pregnant, parturient, breast-feeding

Schizophrenia patients:

• if aged less than 18 years or more than 60 years
• significant secondary effects of antipsychotic medication, measured with the Barnes and AIMS scales
• with a neurodegenerative disease
• with any language disorder (aphasia, SLI, dysarthria, stuttering, etc.)
• with auditory impairment
• pregnant, parturient, breast-feeding

Study Plan

How is the study designed?

Design Details

• Observational Models: Case-Control
• Time Perspectives: Cross-Sectional

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
Labial EMG activity during auditory verbal hallucination	up to 3 years

Collaborators and Investigators

• Sponsor: University Hospital, Grenoble
• Collaborators: GIPSA-LAB
• Investigators: Principal Investigator: Thierry BOUGEROL, MD, PHD, HDR, University Hospital of Grenoble, France

Study record dates

Study Major Dates

• Study Start: October 1, 2009
• Primary Completion (Actual): March 1, 2015
• Study Completion (Actual): March 1, 2015

Study Registration Dates

• First Submitted: June 21, 2013
• First Submitted That Met QC Criteria: June 21, 2013
• First Posted (Estimate): June 25, 2013

Study Record Updates

• Last Update Posted (Estimate): March 10, 2015
• Last Update Submitted That Met QC Criteria: March 9, 2015
• Last Verified: March 1, 2015

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Mental Disorders; Nervous System Diseases; Neurologic Manifestations; Neurobehavioral Manifestations; Schizophrenia Spectrum and Other Psychotic Disorders; Perceptual Disorders; Schizophrenia; Hallucinations
• Other Study ID Numbers: 0906; 2009-A00248-49 (Registry Identifier: ID RCB)