Obesity and Mortality

August 21, 2014 updated by: David Allison, Phd, University of Alabama at Birmingham
Previous analyses of the National Health and Nutrition Examination Survey have suggested that the mortality rate associated with obesity has decreased over calendar time in the U.S. population, potentially due to improvements in the medical care of obesity and its associated diseases. The primary aim of this project is to evaluate whether this reduction in the detrimental association of obesity with mortality rate over calendar time is supported by other data from U.S. prospective studies.

Study Overview

Status

Completed

Conditions

Study Type

Observational

Enrollment (Actual)

311982

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years and older (Adult, Older Adult)

Accepts Healthy Volunteers

Yes

Genders Eligible for Study

All

Sampling Method

Non-Probability Sample

Study Population

U.S. based prospective cohorts of adults

Description

Inclusion Criteria:

  • U.S. based studies with at least 1500 subjects
  • At least 5 years of mortality follow-up
  • BMI measured or self-reported available at 2 or more separate calendar time
  • Subjects varied in age at baseline

Exclusion Criteria:

  • Any study that does not meet the inclusion criteria was excluded

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Multiple Risk Factor Intervention Trial - Usual Group
Multiple Risk Factor Intervention Trial - Referred Group
Framingham Heart study
Framingham Offspring cohort
Atherosclerosis Risk In Communities
Charleston Heart study
Cardiovascular Health study
Rancho Bernardo study
Nurses' Health I study
Panel Study Income Dynamics
MRFIT Referred Care
HDFP Referral Care
Alameda County Health and Ways of Living Study
Nurses' Health II study
Tecumseh County Health study
EPESE-East Boston
Established Populations for Epidemiologic Studies of the Elderly-East Boston
EPESE-Duke
Established Populations for Epidemiologic Studies of the Elderly-Duke
EPESE-Iowa
Established Populations for Epidemiologic Studies of the Elderly-Iowa
EPESE-New Haven
Established Populations for Epidemiologic Studies of the Elderly-New Haven

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
Change in Years of Life Lost Associated with Standard BMI categories Over Calendar Time
Time Frame: Between 1960 and 2000 (up to 40 years)
Between 1960 and 2000 (up to 40 years)

Secondary Outcome Measures

Outcome Measure
Time Frame
Change in Adjusted Hazard Ratio Over Calendar Time for Standard BMI Categories
Time Frame: Between 1960 and 2000 (up to 40 years)
Between 1960 and 2000 (up to 40 years)

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

University of Alabama at Birmingham

Collaborators

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Investigators

  • Principal Investigator: David B Allison, Ph.D., University of Alabama at Birmingham

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

January 1, 2008

Primary Completion (Actual)

December 1, 2013

Study Completion (Actual)

December 1, 2013

Study Registration Dates

First Submitted

June 20, 2013

First Submitted That Met QC Criteria

June 27, 2013

First Posted (Estimate)

June 28, 2013

Study Record Updates

Last Update Posted (Estimate)

August 25, 2014

Last Update Submitted That Met QC Criteria

August 21, 2014

Last Verified

August 1, 2014

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • R01-DK076771-Aim1A
  • R01DK076771 (U.S. NIH Grant/Contract)

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

Clinical Trials on Obesity and Overweight

Search Similar Trials

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Cambodia

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations

3
Subscribe