- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT02074371
Postoperative Respiratory Depression After Cardiac Surgery (CABG PRD)
March 29, 2016 updated by: Ovidiu Constantin Baltatu
Perioperative Parameters to Predict Postoperative Respiratory Depression After Cardiac Surgery
Coronary artery bypass graft surgery (CABG) is associated with postoperative respiratory depression.
In this study we aimed at investigating perioperative parameters that could predict the nadir of postoperative respiratory function impairment.
Study Overview
Status
Completed
Conditions
Detailed Description
Coronary artery bypass graft (CABG) surgery is a principal revascularization option for ischemic heart disease and the principal modality for invasive treatment of coronary artery disease.
Postoperative pulmonary complications are the most frequent and significant contributor to length of hospitalization, morbidity and mortality.
The objective of this study is to search for perioperative parameters that could predict the degree of impairment of respiratory function after CABG with cardiopulmonary bypass (CPB).
Study Type
Observational
Enrollment (Actual)
44
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
Piauí
-
Teresina, Piauí, Brazil, 64001-280
- Hospital Sao Marcos
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years and older (Adult, Older Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Sampling Method
Probability Sample
Study Population
Patients with coronary artery disease submitted to elective CABG with CPB.
Description
Inclusion Criteria:
- patients of both sexes older than 18 years submitted to CABG with CPB, presence of coronary disease confirmed by coronary angiography, use of the left internal thoracic artery and/or saphena, patients who remained in spontaneous ventilation on the first postoperative day, absence of chronic or acute pulmonary disease, and giving written informed consent to participate in the study.
Exclusion Criteria:
- intraoperative change of the surgical technique, surgical complications or complications occurring in the ICU, emergency reoperation, renal failure, failure to agree to continue in the study, presence of other types of heart disease, and presence of pulmonary diseases.
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Observational Models: Case-Crossover
- Time Perspectives: Prospective
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Postoperative Respiratory Depression After Cardiac Surgery
Time Frame: 9 days
|
Respiratory function is assessed through maximal inspiratory (MIP) and expiratory (MEP) pressures and peak expiratory flow (PEF) determined 1 day before surgery and one postoperative week.
|
9 days
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Intraoperative parameters after coronary artery bypass graft surgery (CABG)
Time Frame: 1 day
|
Intraoperative parameters are monitored, including volume of cardioplegia, CPB duration, aortic cross-clamp time, number of grafts.
|
1 day
|
Perioperative parameters after coronary artery bypass graft surgery (CABG)
Time Frame: 3 days
|
ICU blood pressure is monitored
|
3 days
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Investigators
- Study Chair: Ovidiu C Baltatu, MD PhD, Camilo Castelo Branco University (UNICASTELO)
Publications and helpful links
The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.
Helpful Links
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
January 1, 2012
Primary Completion (Actual)
June 1, 2012
Study Completion (Actual)
November 1, 2012
Study Registration Dates
First Submitted
February 26, 2014
First Submitted That Met QC Criteria
February 27, 2014
First Posted (Estimate)
February 28, 2014
Study Record Updates
Last Update Posted (Estimate)
March 30, 2016
Last Update Submitted That Met QC Criteria
March 29, 2016
Last Verified
March 1, 2016
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- BR-002-SJC
- CEP-UESP128/11 (Other Identifier: UESP)
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
product manufactured in and exported from the U.S.
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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