Anomalous Self-Experience in First Episode Psychosis - A Six-Year Follow-Up Study

The objective of this study is to explore the longitudinal course of self-disturbances (SD) in schizophrenia. The main aim of the study is to investigate, in a 6-7-year follow-up of a representative sample of patients with first-episode schizophrenia, bipolar disorder and other psychoses. The overall aim is to expand our knowledge about the role of SDs in psychotic disorders. Increased knowledge here will aid diagnosis and treatment. The current study is a seven year follow-up of this representative cohort, with baseline measures of SDs and a comprehensive clinical and neurocognitive assessment battery.

Study Overview

• Status: Completed
• Conditions: Self Concept; Schizophrenia and Disorders With Psychotic Features; Affective Disorders, Psychotic

• Study Type: Observational
• Enrollment (Actual): 56

Contacts and Locations

Study Locations

• Norway
  • Brumunddal, Norway, 2380
    • Sykehuset Innlandet HF

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 65 years (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Probability Sample

Study Population

Patients reffered to their first adequate treatment for broadly defines psychotic disorders (inkluding both schizophrenia - and bipolar Spectrum disorders) in Oppland and Hedmark counties in Norway, in 2008 - 2009 participated the base-line part of the study(E. Haug, 2012).

Description

Inclusion Criteria:

• Patients who participated and completed base-line part of the study,
• Patients with concurrent substance use disorder are included, but have to demonstrate at least one month without substance use, or clear signs that the psychotic disorder had started before the onset of significant substance use.

Exclusion Criteria:

• Patients with brain injury,
• Patients with on going substance use,
• Unable to provide informed consent statement.
• Not able to be interviewed.

Study Plan

How is the study designed?

Number of groups / cohorts

1

Cohorts and Interventions

Group / Cohort
Follow-Up Group; An earlier investigated cohort with first episode psychosis patients from two Norwegian counties. Being between 18 - 65 years old and being consecutive in- or outpatient referred to first adequate treatment for a DSM-IV diagnosis of schizophrenia, bipolar disorder, or "other psychosis".

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
Change From Baseline in EASE (Examination of Anomalous Self-Experience)Total Score and Subscales of EASE	6 year

Secondary Outcome Measures

Outcome Measure	Time Frame
Change from Baseline for Structured Clinical Interview for the DSM ( SCID-I)(DSM-IV)	6 year

Other Outcome Measures

Outcome Measure	Measure Description	Time Frame
Change From Baseline in Positive and negative syndrome	Positive and Negative Syndrome Scale (PANSS) Total Score and Subscales of PANSS	6 year
Change From Baseline in Calgary Depression Scale Score for Schizophrenia (CDSS)		6 year
Change from Baseline for Alcohol and Drug Use Disorder Identification Test (AUDIT and DUDIT)		6 year
Change from Baseline for neurocognitive tests battery		6 year
Change from Baseline for Global Assessment of Functioning - split Version(GAF)		6 year

Collaborators and Investigators

• Sponsor: Sykehuset Innlandet HF
• Collaborators: Oslo University Hospital

Publications and helpful links

General Publications

• Haug E, Oie M, Andreassen OA, Bratlien U, Nelson B, Aas M, Moller P, Melle I. Anomalous self-experience and childhood trauma in first-episode schizophrenia. Compr Psychiatry. 2015 Jan;56:35-41. doi: 10.1016/j.comppsych.2014.10.005. Epub 2014 Oct 16.
• Haug E, Oie M, Andreassen OA, Bratlien U, Raballo A, Nelson B, Moller P, Melle I. Anomalous self-experiences contribute independently to social dysfunction in the early phases of schizophrenia and psychotic bipolar disorder. Compr Psychiatry. 2014 Apr;55(3):475-82. doi: 10.1016/j.comppsych.2013.11.010. Epub 2013 Nov 28.
• Haug E, Lien L, Raballo A, Bratlien U, Oie M, Andreassen OA, Melle I, Moller P. Selective aggregation of self-disorders in first-treatment DSM-IV schizophrenia spectrum disorders. J Nerv Ment Dis. 2012 Jul;200(7):632-6. doi: 10.1097/NMD.0b013e31825bfd6f.
• Haug E, Oie M, Melle I, Andreassen OA, Raballo A, Bratlien U, Lien L, Moller P. The association between self-disorders and neurocognitive dysfunction in schizophrenia. Schizophr Res. 2012 Mar;135(1-3):79-83. doi: 10.1016/j.schres.2011.11.015. Epub 2011 Dec 3.
• Haug E, Melle I, Andreassen OA, Raballo A, Bratlien U, Oie M, Lien L, Moller P. The association between anomalous self-experience and suicidality in first-episode schizophrenia seems mediated by depression. Compr Psychiatry. 2012 Jul;53(5):456-60. doi: 10.1016/j.comppsych.2011.07.005. Epub 2011 Aug 25.

Study record dates

Study Major Dates

• Study Start: February 1, 2015
• Primary Completion (Actual): December 1, 2016
• Study Completion (Actual): December 1, 2016

Study Registration Dates

• First Submitted: December 17, 2014
• First Submitted That Met QC Criteria: December 19, 2014
• First Posted (Estimate): December 22, 2014

Study Record Updates

• Last Update Posted (Actual): April 27, 2017
• Last Update Submitted That Met QC Criteria: April 26, 2017
• Last Verified: April 1, 2017

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Pathologic Processes; Schizophrenia; Disease; Psychotic Disorders; Mental Disorders; Mood Disorders; Schizophrenia Spectrum and Other Psychotic Disorders; Affective Disorders, Psychotic
• Other Study ID Numbers: 150281