Myocardial and Renal Dysfunction by Oxidative Stress Caused by Cardiac Surgery

August 13, 2019 updated by: Valery V. Likhvantsev, Professor, Moscow Regional Research and Clinical Institute Moniki n.a. M.F. Vladimirskiy
Assessment of the severity of oxidative stress caused by the on-pump and off-pump cardiac surgery using mtDNA, nDNA, carbonilated proteins, nitrotyrosine, oxy-LDL, S100b-protein.

Study Overview

Status

Terminated

Conditions

Study Type

Observational

Enrollment (Actual)

21

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Russian Federation
      • Moscow, Russian Federation, 129110
        • Moscow Regional Research and Clinical Institute Moniki n.a. M.F. Vladimirskiy

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years to 75 years (Adult, Older Adult)

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Sampling Method

Non-Probability Sample

Study Population

primary care clinic

Description

Inclusion Criteria:

  • shedduled CABG

Exclusion Criteria:

  • stroke befor surgery
  • miocardial infarction 6 monthes befor surgery
  • dementia
  • liver cirrhosis

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Observational Models: Cohort
  • Time Perspectives: Retrospective

Cohorts and Interventions

Group / Cohort
valve surgery
valve plasty/replacement surgery
off-pump CABG
CPB-CABG
CABG with CardioPulmonal Bypass

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
Assay of mtDNA
Time Frame: from baseline whithin 72 hours
from baseline whithin 72 hours

Secondary Outcome Measures

Outcome Measure
Time Frame
Assay of nDNA
Time Frame: from baseline whithin 72 hours
from baseline whithin 72 hours
Assay of carbonilated proteins
Time Frame: from baseline whithin 72 hours
from baseline whithin 72 hours
Assay of nitrotyrosine
Time Frame: from baseline whithin 72 hours
from baseline whithin 72 hours
Assay of oxy-LDL
Time Frame: from baseline whithin 72 hours
from baseline whithin 72 hours
Assay of S100b-protein
Time Frame: from baseline whithin 72 hours
from baseline whithin 72 hours

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Moscow Regional Research and Clinical Institute Moniki n.a. M.F. Vladimirskiy

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

March 1, 2015

Primary Completion (Actual)

March 1, 2018

Study Completion (Actual)

December 1, 2018

Study Registration Dates

First Submitted

February 12, 2015

First Submitted That Met QC Criteria

March 16, 2015

First Posted (Estimate)

March 20, 2015

Study Record Updates

Last Update Posted (Actual)

August 15, 2019

Last Update Submitted That Met QC Criteria

August 13, 2019

Last Verified

August 1, 2019

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • OD-CABG-2015

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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