Review of Human Herpes Viruses in Burns

May 19, 2015 updated by: The University of Texas Medical Branch, Galveston

Human Herpes Viruses in Burn Victims: A Systematic Review

Herpes simplex virus, cytomegalovirus and varicella zoster virus infection are purported to play a pivotal role in morbidity and mortality in burns. Thus far, there is no existing systematic review (Level of Evidence III or higher) describing the unique role as well as concurrent infections of these viruses in burns. The aim of this review is to point out the clinical differences between these human herpes virus subtypes, to outline established therapy approaches, and to provide evidence for virus related morbidity and mortality in burns.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

This systematic review was created according the PRIMSA (preferred reporting items for systematic reviews and meta-analyses) guidelines and checklist.

We performed an review of the medical literature to identify all studies that contain HSV, CMV and VZV infections in burns.Therefore, systematic review of the Medline database by using PubMed and Ovid interface was conducted. Also the Web of Science interface was used for systematic literature search.

On the PubMed interface, we used the following search terms: ("HSV"[All Fields] OR "herpes"[All Fields] OR "CMV"[All Fields] OR "cytomegalovirus"[All Fields] OR "VZV"[All Fields] OR "varicella-zoster"[All Fields]) AND ("burns"[MeSH Terms] OR "burns"[All Fields] OR "burn"[All Fields] OR "thermal trauma"[All Fields]). For Ovid we used: exp Burns/ AND (exp Herpes Zoster/ or exp Encephalitis, Herpes Simplex/ or exp Herpes Simplex/ or exp Herpes Simples Virus Vaccines/), exp Burns/ AND (exp Cytomegalovirus/ or exp Cytomegalovirus Infections/), exp Burns/ AND (exp Chickenpox/ or Herpesvirus 3. Human/ or exp Herpes Zoster/). And for Web of Science we used: (TS=(HSV OR herpes OR CMV OR cytomegalovirus OR VZV OR varicella-zoster) AND TS=(burn OR burns OR thermal trauma)) AND LANGUAGE: (English) AND DOCUMENT TYPES: (Article); Timespan: All years; Indexes: SCI-EXPANDED, SSCI, A&HCI, CPCI-S.

Study Type

Observational

Enrollment (Actual)

10267

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Child
  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Sampling Method

Non-Probability Sample

Study Population

Every year, about 500,000 citizens of the United States of America were burned; 50,000 of them were admitted to Burn Center. Bacterial and viral infections including cellulitis, pneumonia, wound infections and septicemia are among the top ten complications of burn injuries. Severe burn injury causes an increased inflammatory response and an overall immunosuppression. As a result severely burned patients are more prone to infections and septicemia. Early treatment of sepsis and prevention of infections are key to reducing morbidity and improving the long-term outcome of burn victims.

Description

Inclusion Criteria:

  • Patients who presented with at least 1% TBSA burned
  • Patients who presented with a viral infections during their hospitalization

Exclusion Criteria:

  • Patients who had no burns
  • Patients who had no viral infections during their hospitalization

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
Burn patients
The included patient are burn victims who sustained a burn of at least 1 % total body surface are (TBSA); with no restriction on age.
Other: Review of the Literature for Human Herpes Virus infections

Review of the Medline database (PubMed and Ovid interface) for human herpes virus infections in burns as well as Web of Science interface.

PRIMSA (preferred reporting items for systematic reviews and meta-analyses) guidelines and checklist were used.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Prevalence of Human Herpes Virus (HHV) Infections
Time Frame: Participants will be followed for the duration of hospital stay, an expected average of 3 months.
HHV include the herpes simplex virus type 1 (HSV-1), herpes simplex virus type 2 (HSV-2), varicella zoster virus (VZV), cytomegalovirus (CMV), Epstein-Barr viruses (EBV) and human herpes virus 6 to 8
Participants will be followed for the duration of hospital stay, an expected average of 3 months.

Secondary Outcome Measures

Outcome Measure
Time Frame
Treatment of Human Herpes Virus (HHV) Infections
Time Frame: Participants will be followed for the duration of hospital stay, an expected average of 3 months.
Participants will be followed for the duration of hospital stay, an expected average of 3 months.

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

The University of Texas Medical Branch, Galveston

Collaborators

Shriners Hospitals for Children

Investigators

  • Study Chair: David N Herndon, MD, FACS, Department of Surgery, University of Texas Medical Branch and Shriners Hospitals for Children, Galveston, Texas, USA

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

March 1, 2015

Primary Completion (Actual)

May 1, 2015

Study Registration Dates

First Submitted

May 14, 2015

First Submitted That Met QC Criteria

May 19, 2015

First Posted (Estimate)

May 22, 2015

Study Record Updates

Last Update Posted (Estimate)

May 22, 2015

Last Update Submitted That Met QC Criteria

May 19, 2015

Last Verified

May 1, 2015

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • SHC-G-SR-HHV

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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