fMRI of Flight of Ideas in Bipolar Disorder (i-TCP)

January 19, 2026 updated by: CHU de Reims

Functional Magnetic Resonance Imaging of Formal Thought Disorders in Bipolar Disorder

Bipolar disorder is a mental disease characterized by mood dysregulation and arises from manic, depressive or mixed episodes. The observations of the patient's speech and language behaviour due to flight of ideas or loss of goal probably result from an underlying disturbance in semantic networks dealing with semantic associations. The aim of our study will be to have a better comprehension of thought disorders in bipolar disorder by cognitive exploration of semantic processing.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

Bipolar disorder is a mental disease characterized by mood dysregulation and arises from manic, depressive or mixed episodes. During these episodes, formal thought disorders are observed, associated to emotional perturbation, behaviour troubles and some psychotic symptoms. During mania, the type of thought disorders observed are derailment, flight of ideas, with an increase in the amount of spontaneous speech and loss of goal. These observations of the patient's speech and language behaviour probably result from an underlying disturbance in semantic networks dealing with semantic associations. These networks have been studied extensively in schizophrenia but remain unknown in bipolar disorder. In this context, the aim of our study will be to have a better comprehension of formal thought disorders in bipolar disorder by cognitive exploration of semantic activation and inhibition.

Study Type

Interventional

Enrollment (Actual)

79

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • France
      • Reims, France, 51092
        • Chu Reims

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years to 65 years (Adult, Older Adult)

Accepts Healthy Volunteers

Yes

Description

Inclusion criteria

BD patients :

  • Men or women, right-handed
  • diagnosis of type 1 bipolar disorder, according to the DSM-IV criteria
  • aged from 18 to 65 years-old
  • Native French speaker
  • Affiliated to the social security

Healthy Controls (HC):

  • Men or women, right-handed
  • aged from 18 to 65 years-old
  • Native French speaker
  • Affiliated to the social security

Exclusion criteria

BD patients :

  • recent alcohol and/or drug abuse or dependence
  • significant general medical illness, including neurological disorders or head trauma
  • sensorial impairment (visual and/or hearing)
  • Contraindication to the use of MRI

HC:

  • first-degree-relative history of bipolar disorder, schizophrenia or schizoaffective disorder according to DSM-IV
  • recent alcohol and/or drug abuse or dependence
  • significant general medical illness, including neurological disorders or head trauma
  • sensorial impairment (visual and/or hearing)
  • Contraindication to the use of MRI

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Other
  • Allocation: Non-Randomized
  • Interventional Model: Parallel Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: Healthy Controls
Other: Functional Magnetic Resonance Imaging
Experimental: Bipolar Disorder patients
Other: Functional Magnetic Resonance Imaging

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
brain activation profiles by Functional Magnetic Resonance Imaging
Time Frame: inclusion visit
inclusion visit

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

CHU de Reims

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

August 1, 2013

Primary Completion (Actual)

April 1, 2018

Study Completion (Actual)

September 1, 2018

Study Registration Dates

First Submitted

May 30, 2016

First Submitted That Met QC Criteria

June 7, 2016

First Posted (Estimated)

June 8, 2016

Study Record Updates

Last Update Posted (Actual)

January 21, 2026

Last Update Submitted That Met QC Criteria

January 19, 2026

Last Verified

May 1, 2016

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • PJ12075

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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