Neural Indices Associated With Relapse in Cannabis Dependence

October 26, 2018 updated by: Benjamin Becker, University of Electronic Science and Technology of China

Altered Neural Activation Patterns of Emotional Processing in Dependent Cannabis Users Associated With Relapse

The aim of this fMRI study is to investigate neural indices of relapse in cannabis dependence. The development and maintenance of drug addictions have been associated with deficits in cognitive control, craving and impaired stress regulation. Therefore, neural markers of brain processes underlying the beforementioned components will be studied. Subsequent follow-up drug use interviews will reveal associations between relapse in cannabis dependence and alterations in brain networks of cognitive control, craving and stress.

Study Overview

Status

Unknown

Conditions

Intervention / Treatment

Study Type

Observational

Enrollment (Anticipated)

75

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Germany
    • North Rhine Westfalia
      • Bonn, North Rhine Westfalia, Germany, 53127
        • Recruiting
        • University of Bonn
        • Contact:
        • Contact:

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years to 40 years (Adult)

Accepts Healthy Volunteers

Yes

Genders Eligible for Study

All

Sampling Method

Non-Probability Sample

Study Population

Cannabis dependent individuals

Description

Inclusion Criteria:

  • Cannabis Dependence
  • 24 hours abstinence

Exclusion Criteria:

  • other DSM-4 diagnosis
  • neurological disorder

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
Healthy control subjects
socio-demographically matched
Other: fMRI
Cannabis Dependence
ages 18-40
Other: fMRI

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
fMRI neural activation patterns of emotional processing
Time Frame: one time point = fMRI assessment after minimum 24 hours of abstinence
Activation patterns associated with emotion processing, emotion regulation, craving and stress are determined in addicted cannabis users compared to non-using matched control subjects
one time point = fMRI assessment after minimum 24 hours of abstinence

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Timeline Followback Interviews
Time Frame: one time point = 12 months after fMRI data acquisition
Association between fMRI correlates and drug use during follow up preiod as predictor for relapse
one time point = 12 months after fMRI data acquisition

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

University of Electronic Science and Technology of China

Collaborators

German Research Foundation
University Hospital, Bonn

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

February 1, 2016

Primary Completion (Anticipated)

March 1, 2019

Study Completion (Anticipated)

March 1, 2019

Study Registration Dates

First Submitted

June 11, 2016

First Submitted That Met QC Criteria

June 11, 2016

First Posted (Estimate)

June 15, 2016

Study Record Updates

Last Update Posted (Actual)

October 29, 2018

Last Update Submitted That Met QC Criteria

October 26, 2018

Last Verified

October 1, 2018

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • ART_Can_03

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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