- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03039556
Step-reduction in Older Men and Women (CDA-SR)
January 31, 2017 updated by: Stuart Phillips, McMaster University
The Influence of Acute Physical Inactivity on Metabolic Function in Older Men and Women
This study investigates the effects of two weeks of reduced daily ambulation and a subsequent return to normal physical activity on metabolic health of older adults.
Study Overview
Status
Completed
Conditions
Intervention / Treatment
Detailed Description
Aging results in a progressive loss of muscle mass that is accelerated by periods of muscular disuse, common for older adults during hospitalization or convalescence from illness.
Transient physical inactivity has been shown to cause muscular atrophy and impairments in insulin sensitivity in both younger and older adults.
However, the recovery capacity of older adults after such physical inactivity remains unknown.
This study aims to determine the impact of two weeks of daily step reduction to ≤1000 steps per day, an experimental model mimicking short-term physical inactivity, on glycemic control in older adults and further investigate whether older adults are able to recover from the consequences of this inactivity simply by returning to their habitual activity for 14 days.
Study Type
Interventional
Enrollment (Actual)
22
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
Ontario
-
Hamilton, Ontario, Canada, L8S 4K1
- Exercise Metabolism Research Laboratory, McMaster Univeristy
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
65 years to 80 years (Older Adult)
Accepts Healthy Volunteers
Yes
Genders Eligible for Study
All
Description
Inclusion Criteria:
- Non-smoker
Exclusion Criteria:
- Use of assistive walking devices
- Chronic use of analgesic or anti-inflammatory drugs
- History of neuromuscular problems or muscle and/or bone wasting disease
- Acute or chronic illness including cardiac, pulmonary, liver or kidney abnormalities, uncontrolled hypertension, insulin or non-insulin dependent diabetes or other metabolic disorders
- Daily use of statins, particularly simvastatin and atorvastatin
- Use of medications known to affect protein metabolism
- Normally complete fewer than 3000 steps per day
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Basic Science
- Allocation: N/A
- Interventional Model: Single Group Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: Change in physical activity for older adults
Older adult participants undergo alterations in daily ambulation by completing Normal Daily Steps for one week, followed by a two-week Step-Reduction and a subsequent Return to Normal Daily Steps for two weeks
|
Complete normal daily ambulation for one week
Reduce daily ambulation to fewer than 1000 steps per day for two weeks
Increase daily ambulation to 100% of normal daily step-count for two weeks
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Change in Insulin Sensitivity
Time Frame: Measured at the end of each behavioural intervention (Week 1, Week 3, Week 5)
|
Assessed via Matsuda ISI
|
Measured at the end of each behavioural intervention (Week 1, Week 3, Week 5)
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Change in lean tissue mass
Time Frame: Measured at the end of each behavioural intervention (Week 1, Week 3, Week 5)
|
Assessed via Dual Energy X-Ray Absorptiometry
|
Measured at the end of each behavioural intervention (Week 1, Week 3, Week 5)
|
Change in Peak Isometric Maximal Voluntary Leg Extension Strength
Time Frame: Measured at the end of each behavioural intervention (Week 1, Week 3, Week 5)
|
Assessed via muscle dynamometry
|
Measured at the end of each behavioural intervention (Week 1, Week 3, Week 5)
|
Change in Muscle Protein Synthesis
Time Frame: Measured at the end of each behavioural intervention (Week 1, Week 3, Week 5)
|
Obtained via vastus lateralis muscle biopsy
|
Measured at the end of each behavioural intervention (Week 1, Week 3, Week 5)
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Collaborators
Publications and helpful links
The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.
General Publications
- Breen L, Stokes KA, Churchward-Venne TA, Moore DR, Baker SK, Smith K, Atherton PJ, Phillips SM. Two weeks of reduced activity decreases leg lean mass and induces "anabolic resistance" of myofibrillar protein synthesis in healthy elderly. J Clin Endocrinol Metab. 2013 Jun;98(6):2604-12. doi: 10.1210/jc.2013-1502. Epub 2013 Apr 15.
- Devries MC, Breen L, Von Allmen M, MacDonald MJ, Moore DR, Offord EA, Horcajada MN, Breuille D, Phillips SM. Low-load resistance training during step-reduction attenuates declines in muscle mass and strength and enhances anabolic sensitivity in older men. Physiol Rep. 2015 Aug;3(8):e12493. doi: 10.14814/phy2.12493.
- McGlory C, von Allmen MT, Stokes T, Morton RW, Hector AJ, Lago BA, Raphenya AR, Smith BK, McArthur AG, Steinberg GR, Baker SK, Phillips SM. Failed Recovery of Glycemic Control and Myofibrillar Protein Synthesis With 2 wk of Physical Inactivity in Overweight, Prediabetic Older Adults. J Gerontol A Biol Sci Med Sci. 2018 Jul 9;73(8):1070-1077. doi: 10.1093/gerona/glx203.
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
September 1, 2015
Primary Completion (Actual)
May 1, 2016
Study Completion (Actual)
May 1, 2016
Study Registration Dates
First Submitted
January 13, 2017
First Submitted That Met QC Criteria
January 31, 2017
First Posted (Estimate)
February 1, 2017
Study Record Updates
Last Update Posted (Estimate)
February 1, 2017
Last Update Submitted That Met QC Criteria
January 31, 2017
Last Verified
January 1, 2017
More Information
Terms related to this study
Other Study ID Numbers
- 0574
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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