Step-reduction in Older Men and Women (CDA-SR)

January 31, 2017 updated by: Stuart Phillips, McMaster University

The Influence of Acute Physical Inactivity on Metabolic Function in Older Men and Women

This study investigates the effects of two weeks of reduced daily ambulation and a subsequent return to normal physical activity on metabolic health of older adults.

Study Overview

Detailed Description

Aging results in a progressive loss of muscle mass that is accelerated by periods of muscular disuse, common for older adults during hospitalization or convalescence from illness. Transient physical inactivity has been shown to cause muscular atrophy and impairments in insulin sensitivity in both younger and older adults. However, the recovery capacity of older adults after such physical inactivity remains unknown. This study aims to determine the impact of two weeks of daily step reduction to ≤1000 steps per day, an experimental model mimicking short-term physical inactivity, on glycemic control in older adults and further investigate whether older adults are able to recover from the consequences of this inactivity simply by returning to their habitual activity for 14 days.

Study Type

Interventional

Enrollment (Actual)

22

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

    • Ontario
      • Hamilton, Ontario, Canada, L8S 4K1
        • Exercise Metabolism Research Laboratory, McMaster Univeristy

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

65 years to 80 years (Older Adult)

Accepts Healthy Volunteers

Yes

Genders Eligible for Study

All

Description

Inclusion Criteria:

  • Non-smoker

Exclusion Criteria:

  • Use of assistive walking devices
  • Chronic use of analgesic or anti-inflammatory drugs
  • History of neuromuscular problems or muscle and/or bone wasting disease
  • Acute or chronic illness including cardiac, pulmonary, liver or kidney abnormalities, uncontrolled hypertension, insulin or non-insulin dependent diabetes or other metabolic disorders
  • Daily use of statins, particularly simvastatin and atorvastatin
  • Use of medications known to affect protein metabolism
  • Normally complete fewer than 3000 steps per day

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Basic Science
  • Allocation: N/A
  • Interventional Model: Single Group Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: Change in physical activity for older adults
Older adult participants undergo alterations in daily ambulation by completing Normal Daily Steps for one week, followed by a two-week Step-Reduction and a subsequent Return to Normal Daily Steps for two weeks
Complete normal daily ambulation for one week
Reduce daily ambulation to fewer than 1000 steps per day for two weeks
Increase daily ambulation to 100% of normal daily step-count for two weeks

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Change in Insulin Sensitivity
Time Frame: Measured at the end of each behavioural intervention (Week 1, Week 3, Week 5)
Assessed via Matsuda ISI
Measured at the end of each behavioural intervention (Week 1, Week 3, Week 5)

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Change in lean tissue mass
Time Frame: Measured at the end of each behavioural intervention (Week 1, Week 3, Week 5)
Assessed via Dual Energy X-Ray Absorptiometry
Measured at the end of each behavioural intervention (Week 1, Week 3, Week 5)
Change in Peak Isometric Maximal Voluntary Leg Extension Strength
Time Frame: Measured at the end of each behavioural intervention (Week 1, Week 3, Week 5)
Assessed via muscle dynamometry
Measured at the end of each behavioural intervention (Week 1, Week 3, Week 5)
Change in Muscle Protein Synthesis
Time Frame: Measured at the end of each behavioural intervention (Week 1, Week 3, Week 5)
Obtained via vastus lateralis muscle biopsy
Measured at the end of each behavioural intervention (Week 1, Week 3, Week 5)

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

September 1, 2015

Primary Completion (Actual)

May 1, 2016

Study Completion (Actual)

May 1, 2016

Study Registration Dates

First Submitted

January 13, 2017

First Submitted That Met QC Criteria

January 31, 2017

First Posted (Estimate)

February 1, 2017

Study Record Updates

Last Update Posted (Estimate)

February 1, 2017

Last Update Submitted That Met QC Criteria

January 31, 2017

Last Verified

January 1, 2017

More Information

Terms related to this study

Other Study ID Numbers

  • 0574

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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