Bogota School Children Cohort (BoSCCo)

This observational study investigates the associations of nutritional indicators, biomarkers, sociodemographic conditions, and infections with child health, as well as physical, behavioral, and cognitive development. Investigators recruited a random sample of 3202 children from primary public schools in Bogota, Colombia in February 2006 and followed them for a median of 6.5 years. Investigators hypothesized that poor nutritional status at the time of recruitment in middle childhood would be related to adverse health outcomes through adolescence.

Study Overview

• Status: Completed
• Conditions: Child Health; Nutrition; Behavior Problem; Infectious Morbidity; Child Growth; Neurocognitive Development; Sexual Maturation

• Study Type: Observational
• Enrollment (Actual): 3202

Contacts and Locations

Study Locations

• Colombia
  • Bogota, Colombia
    • FINUSAD - Foundation for Research in Nutrition and Health
  • Chia, Colombia
    • University of La Sabana

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 5 years to 12 years (Child)
• Accepts Healthy Volunteers: N/A
• Genders Eligible for Study: All

• Sampling Method: Probability Sample

Study Population

Children were selected from primary public schools in Bogota, Colombia.

Description

Inclusion Criteria:

• Primary public school enrollment in February 2006

Exclusion Criteria:

• None

Study Plan

How is the study designed?

Number of groups / cohorts

1

Cohorts and Interventions

Group / Cohort

Bogota School Children Cohort; Children are classified according to exposure levels of: Micronutrient biomarker indicators: Ferritin; Hemoglobin; Mean corpuscular volume; Zinc; Vitamin A; Vitamin B12; Folate; Vitamin D Serum fatty acids Inflammatory biomarkers: C-reactive protein Diet Socioeconomic status indicators Anthropometric indicators Incidence of infectious morbidity symptoms DNA biomarkers

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Externalizing behavior problems	Adolescent behavior problems were ascertained with the Youth Self Report (YSR) questionnaire. The YSR is a self-administered questionnaire consisting of 112 statements addressing behaviors or feelings that adolescents rate as false, sometimes true, or very/often true. From responses to these questions, an Assessment Data Manager (ADM) software calculates continuous scores for aggressive behavior and rule breaking behavior. The sum of the aggressive and rule breaking behavior subscale scores constitute the total externalizing problems score.	Assessed at one point in time when the children were 11-18 years old.
Internalizing behavior problems	Adolescent behavior problems were ascertained with the Youth Self Report (YSR) questionnaire. The sum of the anxious/depressed, withdrawn/depressed, and somatic complaint subscale scores constitute the total internalizing problems score.	Assessed at one point in time when the children were 11-18 years old.

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Behavior problem subscale scores (aggressive behavior, rule breaking behavior, anxious/depressed, withdrawn/depressed, somatic complaints, attention problems, social problems, and thought problems)	Adolescent behavior problems were ascertained with the Youth Self Report (YSR) questionnaire.	Assessed at one point in time when the children were 11-18 years old.

Other Outcome Measures

Outcome Measure	Measure Description	Time Frame
Body mass index change	Change in body mass index for age Z-score from baseline to the last follow-up visit	Median 6.5 years from recruitment
Linear growth	Change in height for age Z-score from baseline to the last follow-up visit	Median 6.5 years from recruitment
Age at menarche	Reported age at first menstrual period	Median 6.5 years from recruitment
Grade repetition	Outcome of school grades between 2006-2011	5 years
Blood pressure		Median 6.5 years from recruitment

Collaborators and Investigators

• Sponsor: University of Michigan
• Collaborators: Universidad de la Sabana; Foundation for Research in Nutrition and Health (FINUSAD)
• Investigators: Principal Investigator: Eduardo Villamor, MD MPH DrPH, University of Michigan

Publications and helpful links

General Publications

• Robinson SL, Marin C, Oliveros H, Mora-Plazas M, Richards BJ, Lozoff B, Villamor E. Iron Deficiency, Anemia, and Low Vitamin B-12 Serostatus in Middle Childhood Are Associated with Behavior Problems in Adolescent Boys: Results from the Bogota School Children Cohort. J Nutr. 2018 May 1;148(5):760-770. doi: 10.1093/jn/nxy029.

Study record dates

Study Major Dates

• Study Start (Actual): February 1, 2006
• Primary Completion (Actual): August 11, 2015
• Study Completion (Actual): August 11, 2015

Study Registration Dates

• First Submitted: September 26, 2017
• First Submitted That Met QC Criteria: September 28, 2017
• First Posted (Actual): September 29, 2017

Study Record Updates

• Last Update Posted (Actual): September 29, 2017
• Last Update Submitted That Met QC Criteria: September 28, 2017
• Last Verified: September 1, 2017

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Behavioral Symptoms; Problem Behavior
• Other Study ID Numbers: HUM00043252

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No