Nephropathy in Patients With Sickle Cell Disease

Pattern of Sickle Cell Nephropathy in Patients With Sickle Cell Disease

There are some diseases that give rise to diverse renal manifestations as does sickle cell disease

Study Overview

• Status: Unknown
• Conditions: Sickle Cell Nephropathy
• Intervention / Treatment: Other: patient with sickle cell disease

Detailed Description

Such involvement adversely affects virtually all major physiological processes in the kidney, and leads to complications that are common and chronic on the one hand (such as impaired urinary concentrating ability), and those that are rare and uniformly fatal on the other (such as renal medullary carcinoma) This steady adverse renal sequelae shortens the average lifespan of patients with SCD.

Proteinuria and a reduced glomerular filtration rate are risk factors associated with increased mortality among those patients with approximately 16-18% of overall mortality in this patient group is due to kidney disease.

Once end stage renal disease is reached, the mortality of patients who are on haemodialysis and have SCD is increased severalfold relative to the mortality of patients who are on haemodialysis but do not have SCD.

Thus,although the average lifespan of patients with SCD has increased during recent decades owing to improved management of complications outside the kidney,kidney disease contributes substantially to the still increased mortality in SCD.

• Study Type: Observational
• Enrollment (Anticipated): 25

Contacts and Locations

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 5 months to 18 years (Child, Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Probability Sample

Study Population

to assess degree of renal affection in patients with sickle cell disease attending Assuit university Children hospital by estimating some predictors of glomerular and tubular dysfunction.detailed history taking and thorough clinical examination and laboratory investigations

Description

Inclusion Criteria:

• All patients with sickle cell anemia attending the unit will be included in the study.

Exclusion Criteria:

• patient with any underlaying systemic diseases other than sickle cell anaemia

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
sickle cell nephropathy in patient with sickle cell disease	detection of renal impairment in patients with sickle cell disease by estamating gloerular and tubular dysfunction clinicaly and laboratory	one year

Collaborators and Investigators

• Sponsor: Assiut University
• Investigators: Principal Investigator: omnia talat hasan, Assiut

Study record dates

Study Major Dates

• Study Start (Anticipated): May 1, 2020
• Primary Completion (Anticipated): May 30, 2020
• Study Completion (Anticipated): January 1, 2021

Study Registration Dates

• First Submitted: September 20, 2018
• First Submitted That Met QC Criteria: September 20, 2018
• First Posted (Actual): September 21, 2018

Study Record Updates

• Last Update Posted (Actual): November 29, 2019
• Last Update Submitted That Met QC Criteria: November 27, 2019
• Last Verified: November 1, 2019

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Urologic Diseases; Hematologic Diseases; Genetic Diseases, Inborn; Anemia; Anemia, Hemolytic, Congenital; Anemia, Hemolytic; Hemoglobinopathies; Kidney Diseases; Anemia, Sickle Cell
• Other Study ID Numbers: npscd

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: UNDECIDED

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No