- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03721198
RMGI Varnish Versus APF Gel in Prevention of White Spot Lesions During Orthodontic Treatment
Resin-modified Glass Ionomer Varnish Versus Acidulated Phosphorus Fluoride Gel in Prevention of White Spot Lesions During Comprehensive Orthodontic Treatment: (Split Mouth Randomized Clinical Trial)(A Comparative Study)
evaluate the effect of a single application of Clinpro XT varnish on enamel demineralization adjacent to orthodontic brackets during fixed orthodontic treatment in comparison with acidulated phosphorus fluoride gel.
this study is to assess the durability of the results obtained from both materials (Clinpro XT Varnish- APF Gel) this study is to determine the degree of
patients' satisfaction after the use of both materials (Clinpro XT Varnish -
APF Gel)
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
This clinical study will be held in the orthodontic clinic, Faculty of dentistry, Cairo University, Egypt Principal investigator (MZ) will select and examine the patients according to the inclusion criteria.
Tooth preparation procedure:
Excessive saliva in Upper six anterior teeth will be removed by cotton rolls or by using an air syringe without excessive drying. Principal investigator (MZ) will take a photograph for each tooth using A Digital DSLR camera (canon 700d with lens 100 macro 2.8) and this photograph is T0(before application of the gel)
Intervention and comparator:
Bonding procedure before application of intervention and comparator
Upper six anterior teeth will be cleaned with pumice, rinsed and dried thoroughly. The area where the bracket is to be placed will be etched with a 37% orthophosphoric acid gel for 15 seconds and then rinsed with water. After rinsing, the enamel surface will be dried with compressed moisture and oil free air. A layer of primer will be applied to the tooth and bracket mesh. Adhesive paste will be applied to the base of the bracket and pressed firmly onto the tooth surface. Excess adhesive will be removed, and the adhesive light cured for 20 seconds.
Preparation of clinpro XT (intervention)
In upper right anterior teeth, the polished tooth surface is etched using 37% orthophosphoric acid gel. applied for 15 seconds over the labial enamel surface extending from gingival surface of the bracket to the free gingival margin. Then, the surface is rinsed thoroughly by water spray and dried with compressed moisture and oil free air to remove the etchant. The paste and liquid components of the varnish are mixed on a paper pad for 10-15 seconds by a small plastic spatula. When the mix material appears glossy and smooth in consistency, it is applied as a thin layer over the etched enamel surface by a ball applicator. Care should be taken to avoid prolonged contact of uncured material with soft tissues.
If accidental contact occurred, the material is immediately wiped off with wet cotton roll. Then, the varnish is light cured with the visible light-curing unit for 20 s.Oral hygiene instruction will be given to the patient e.g. tooth brushing twice a day with fluoride toothpaste.
A photograph will be taken for the labial surface of each upper right anterior tooth using the same camera by the outcome assessor (MS) after 3 months (T1) and 6 months (T2) of orthodontic treatment.
- Preparation of Acidulated Phosphorus Fluoride (Comparator):
Acidulated Phosphorus Fluoride gel will be applied directly over the labial enamel surface extending from gingival surface of the bracket to the free gingival margin using a small brush/swab to spread the gel over the surface. The gel will be left in place for four minutes then washed. Patients will be instructed not to rinse, eat, drink or smoke for the next 30 minutes.
Study Type
Enrollment (Anticipated)
Phase
- Not Applicable
Contacts and Locations
Study Contact
- Name: Mohamed Zidan, BDS
- Phone Number: 01157625577
- Email: Dr_mhmdzidan@yahoo.com
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
- Child
- Adult
- Older Adult
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- Patient indicating for fixed orthodontic treatment with healthy gingival and periodontal condition
Exclusion Criteria:
- Presence of enamel hypoplasia or dental fluorosis.
- Presence of tetracycline pigmentation.
- Periodontal pocketing of 3mm or greater.
- Presence of carious cavities.
- Smokers.
- Allergy to fluoride gel being used in study.
- Patient that have systemic disease.
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Prevention
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Active Comparator: Acidulated phosphorous flouride
Acidulated phosphorous flouride used once at the first of the study
|
Acidulated phosphorous flouride is used to prevent white spot lesions
Other Names:
|
Experimental: Resin modified glass ionomer varnish
Resin modified glass ionomer varnish (CLINPRO XT ) is used once at the first of the study only
|
Resin modified glass ionomer varnish is used to prevent white spot lesions
Other Names:
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Colour change
Time Frame: 6 months
|
Colour change using spectrophotometer
|
6 months
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Colour stability
Time Frame: 6 months
|
Colour stability using spectrophotometer
|
6 months
|
Other Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Patient satisfaction: VAS APF Gel)
Time Frame: 6 months
|
Patient satisfaction using visual analogue scale A scale to assess the patient satisfaction A scale from 0 to 10 10 means fully satisfied by the results 0 means unsatisfied by the result
|
6 months
|
Collaborators and Investigators
Sponsor
Collaborators
Investigators
- Study Chair: mohamed Saied, Orthodontic Department
Study record dates
Study Major Dates
Study Start (Anticipated)
Primary Completion (Anticipated)
Study Completion (Anticipated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Other Study ID Numbers
- RMGI Varnish-WSL prevention
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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