Artificial Intelligence to Assess the Association Between Facial Characteristics and Coronary Artery Diseases

August 17, 2019 updated by: China National Center for Cardiovascular Diseases
The purposes of this study are 1) to explore the association between facial characteristics and the increased risk of coronary artery diseases; 2) to evaluate the diagnostic efficacy of appearance factors for coronary artery diseases.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

Several age-related appearance factors were described associated with increased risk of coronary artery diseases (CAD). However, several limitations made these facial risk factors hard to be utilized in clinical practice, including 1) low prevalence in CAD patients, 2) lack of specific definition, 3) poor reproducibility in artificial recognition.

Thus, the investigators designed a multi-center, cross-sectional study to explore the association between facial characteristics and CAD and evaluate the diagnostic efficacy of appearance factors for CAD. The investigators will recruit patients undergoing coronary angiography or coronary computer tomography angiography. Patients' baseline information and facial images will be collected. First, the investigators will explore the facial factors associated with CAD by using artificial intelligence technology to compare facial photographs between patients with CAD and without CAD. Secondary, the investigators will evaluate the dose-response relationship between facial characteristics and CAD. Third, the investigators will establish a CAD risk model based on facial factors, and evaluate the diagnostic effect of the model.

Study Type

Observational

Enrollment (Actual)

6864

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • China
    • Beijing
      • Beijing, Beijing, China, 100032
        • Fuwai Hospital
      • Beijing, Beijing, China, 100032
        • Beijing Anzhen Hospital
      • Beijing, Beijing, China, 100032
        • Guanganmen Hospital, Chinese Academy of Traditional Chinese Medicine
    • Hubei
      • Wuhan, Hubei, China, 430000
        • Wuhan Union Hospital
    • Jiangsu
      • Xuzhou, Jiangsu, China, 221000
        • Xuzhou Third People's Hospital
    • Liangning
      • Dalian, Liangning, China, 116000
        • The First Affiliated Hospital of Dalian Medical University
    • Shanghai
      • Shanghai, Shanghai, China, 200000
        • Shanghai East Hospital
      • Shanghai, Shanghai, China, 200000
        • Shanghai Renji Hospital
    • Zhejiang
      • Wenzhou, Zhejiang, China, 325000
        • The fisrt affiliated hospital of Wenzhou medical university

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years and older (Adult, Older Adult)

Accepts Healthy Volunteers

Yes

Genders Eligible for Study

All

Sampling Method

Non-Probability Sample

Study Population

Patients who undergo coronary angiography or coronary computer tomography angiography from both resident patients and outpatient.

Description

Inclusion Criteria:

  • Undergoing coronary angiography or coronary computer tomography angiography
  • Written informed consent

Exclusion Criteria:

  • Prior percutaneous coronary intervention (PCI)
  • Prior coronary artery bypass graft (CABG)
  • Screening coronary artery disease before treating other heart diseases
  • Without blood biochemistry outcome
  • With artificially facial alteration (i.e. cosmetic surgery, facial trauma or make-up)
  • Other situations which make patients fail to be photographed

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
Model establishment and test group
Patients undergoing coronary angiography or coronary computer tomography angiography will be enrolled. Patients data will be used to establish the facial based diagnostic model of coronary artery diseases, and to prospectively validate the diagnostic effectiveness of the model.
Other: No intervention
No intervention

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Sensitivity of diagnostic model
Time Frame: at the end of enrollment (6 months)
The sensitivity of coronary artery diagnostic model assessed in model test group
at the end of enrollment (6 months)

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Specificity of diagnostic model
Time Frame: at the end of enrollment (6 months)
The specificity of coronary artery diagnostic model assessed in model test group
at the end of enrollment (6 months)
Specificity of diagnostic model
Time Frame: at the end of enrollment (6 months)
Area under receiver operating curve (AUC) of diagnostic model assessed in model test group
at the end of enrollment (6 months)
Positive predictive value (PPV)
Time Frame: at the end of enrollment (6 months)
PPV of diagnostic model assessed in model test group
at the end of enrollment (6 months)
Negative predictive value (NPV)
Time Frame: at the end of enrollment (6 months)
NPV of diagnostic model assessed in model test group
at the end of enrollment (6 months)
Diagnostic accuracy rate
Time Frame: at the end of enrollment (6 months)
Diagnostic accuracy rate of diagnostic model assessed in model test group
at the end of enrollment (6 months)

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

China National Center for Cardiovascular Diseases

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

July 10, 2017

Primary Completion (Actual)

August 2, 2019

Study Completion (Actual)

August 2, 2019

Study Registration Dates

First Submitted

November 4, 2018

First Submitted That Met QC Criteria

November 4, 2018

First Posted (Actual)

November 6, 2018

Study Record Updates

Last Update Posted (Actual)

August 20, 2019

Last Update Submitted That Met QC Criteria

August 17, 2019

Last Verified

August 1, 2019

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 20181104-2017-907

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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