- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03911011
Physiological Values When Breathing in an Air-pocket. Mountain Lab 2019 (ML2019)
Gas Diffusion in and Out of an Air Pocket After a Simulated Snow Avalanche and Its Impacts on Human Physiological Parameters.
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
In a controlled and simulated avalanche scenario the investigators want to investigate how oxygen (O2) and carbon dioxide (CO2) diffuse and how rebreathing of CO2 in addition to mild hypoxia influence standardized physiological parameters in two scenarios: Fresh air and no fresh air delivered into the air pocket. The project is a field study designed to measure and document gas diffusion through snow. The outcome measures are: (1) Concentration of O2 and CO2 in the air pocket and 50 cm from the pocket. (2) Time interval for development of threshold values for concentration of O2 and CO2. The investigators will also monitor physiologic measures such as: Electrocardiogram (ECG), continuous invasive blood pressure, cerebral oximetry, continuous pulse oximetry, transthoracic impedance, and gas content in expired air. Subjective evaluation of comfort will also be scored. Twenty healthy young volunteers with written consent to participate will be used as test subjects.
The study may have a clinical consequence for better outcome, for victims of avalanches by providing additional air or oxygen close to the patient. We will also measure specific body measures and spirometry.
Study Type
Enrollment (Anticipated)
Phase
- Not Applicable
Contacts and Locations
Study Contact
- Name: Oyvind Thomassen, PhD
- Phone Number: +4797718721
- Email: oyvt@helse-bergen.no
Study Locations
-
-
-
Bergen, Norway
- Recruiting
- Haukeland University Hospital
-
Contact:
- Hanne Klausen, PhD
- Phone Number: +4791132092
- Email: hanne.klausen@helse-bergen.no
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
- Child
- Adult
- Older Adult
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- Healthy, non smoking, normal BMI
Exclusion Criteria:
- None
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Crossover Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Active Comparator: Fresh air
2 litres of fresh air
|
Fresh air insufflation of 2 L/min toward mouth/nose.
|
No Intervention: no fresh air
no supply of fresh air
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Time
Time Frame: 25 minutes
|
Time to reaching a threshold of physiology parameters or time limit
|
25 minutes
|
Other Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Physiology
Time Frame: 25 minutes
|
Values of Physiology parameters
|
25 minutes
|
Collaborators and Investigators
Sponsor
Collaborators
Investigators
- Study Director: Hanne Klausen, PhD, Director, Department for Anaesthesia and Intensive Care
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Anticipated)
Study Completion (Anticipated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Other Study ID Numbers
- 2018/2478
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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