- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03951974
A Social Emotion Regulation Intervention in MS
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
Multiple sclerosis (MS) is a progressive and debilitating neurological disease which not only affects a patient's physical health, but also adversely affects their mental health. Depressed mood is common in MS, and poor mental health in individuals with MS has wide-ranging consequences on social relationships and community integration. The preponderance of negative emotions and sparsity of positive emotions in MS are attributable in part to ineffective emotion regulation strategies. Thus, the clinical trial seeks to evaluate the effectiveness of an intervention which instructs individuals on using the social regulation of emotion.
The social regulation of emotion occurs when a one's emotional state benefits from an interaction with another person, such as when seeking comfort from a trusted friend. The current intervention was designed to leverage existing social relationships for emotional support in a manner which should strengthen the perception of social support and also reinforce existing relationships. The primary goal of this trial is to examine changes in mental well-being after treatment.
Study Type
Enrollment (Anticipated)
Phase
- Not Applicable
Contacts and Locations
Study Locations
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New Jersey
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East Hanover, New Jersey, United States, 07936
- Kessler Foundation
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- Multiple Sclerosis diagnosis
- English language fluency
Exclusion Criteria:
- currently taking steroids or benzodiazepines
- within 30 days of an exacerbation
- history of substance abuse
- diagnosis of bipolar, schizophrenia, epilepsy, stroke
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Basic Science
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Triple
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
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Experimental: Experimental
Participants in the experimental group will receive training in utilizing social regulation of emotion strategies in an individualized format.
They will meet with an interventionist for 5 weeks (1 in-person session and 4 telephone sessions) for 1-1.5 hours each week, and keep a journal documenting their emotion challenges and regulation strategy use.
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Participants will work one-on-one with an interventionist to develop goals (in the form of implementation intentions) to develop social emotion regulation strategies to combat frequent emotional challenges.
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Other: Control
Participants in the control group will not receive training in utilizing social regulation of emotion strategies.
While they will still meet with the interventionist on the same schedule and for approximately the same length of time, they will simply be asked to report the emotion regulation strategies that they naturally employ.
They will also keep a journal documenting their emotion challenges and regulation strategy use.
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Participants will work one-on-one with an interventionist to report on their frequent emotional challenges, and report the emotion regulation strategies that they frequently use to combat them.
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Well-being: Depression
Time Frame: Scores will be assessed at two time-points, baseline (week 1) and post-intervention (week 6)
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Change in scores on a self-report questionnaire of depression (the Center for Epidemiologic Studies Depression Scale, a 20-item scale with higher scores indicating greater depression)
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Scores will be assessed at two time-points, baseline (week 1) and post-intervention (week 6)
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Well-being: Stress
Time Frame: Scores will be assessed at two time-points, baseline (week 1) and post-intervention (week 6)
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Change in scores on a self-report questionnaire of stress (the Perceived Stress Scale, a 10-item scale with higher scores reflecting higher stress)
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Scores will be assessed at two time-points, baseline (week 1) and post-intervention (week 6)
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Well-being: Quality of life
Time Frame: Scores will be assessed at two time-points, baseline (week 1) and post-intervention (week 6)
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Change in scores on a self-report questionnaire of quality of life (the Satisfaction with Life Scale, a five item scale where higher scores reflect higher satisfaction)
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Scores will be assessed at two time-points, baseline (week 1) and post-intervention (week 6)
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Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Perceived social support
Time Frame: Scores will be assessed at two time-points, baseline (week 1) and post-intervention (week 6)
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Change in scores on a self-report questionnaire of perceived social support (the Multidimensional Scale of Perceived Social Support, a 12-item scale where higher scores reflect greater support)
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Scores will be assessed at two time-points, baseline (week 1) and post-intervention (week 6)
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Collaborators and Investigators
Sponsor
Investigators
- Principal Investigator: Katie Lancaster, PhD, Kessler Foundation
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Anticipated)
Study Completion (Anticipated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- PC 8-19
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
IPD Plan Description
IPD Sharing Time Frame
IPD Sharing Access Criteria
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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