Cognitive, Psychological and Electrophysiological Attributes to Suicide Among Depressed Patients

This study will try to provide a better understanding of the psychological, cognitive and electrophysiological factors that contribute to suicide in depressed patients.

Study Overview

• Status: Unknown
• Conditions: Suicide; Major Depressive Disorder; Quantitative EEG (qEEG)
• Intervention / Treatment: Diagnostic test: Quantitative EEG

Detailed Description

Objectives:

1. To investigate the ability of qEEG to suspect suicidal potential in patients diagnosed with major depression.
2. To test the ability of some psychological and cognitive elements in determining the likelihood of suicide in such patients.
3. To give an objective and more reliable method than traditional questionnaires to assess the seriousness of suicidal ideations in patients suffering from depression who usually don't reveal their actual intentions.

• Study Type: Observational
• Enrollment (Anticipated): 50

Contacts and Locations

Study Locations

• Egypt
  • Dakahlia
    • Mansoura, Dakahlia, Egypt, 35516
      • Recruiting
      • Mansoura University Hospital
      • Contact: Shady I Mashaly, MD; Phone Number: +201015028364; Email: dr.shadymashaly@gmail.com
      • Contact: Noha a Amer, MD; Phone Number: +201002025960; Email: noha.amer87@gmail.com

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 16 years to 65 years (Child, Adult, Older Adult)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: All

• Sampling Method: Probability Sample

Study Population

50 Egyptian patients will be recruited from Mansoura University Hospitals at the outpatient clinics and the inpatient department.

Description

Inclusion Criteria:

• Age between 16 and 65 years
• Both males and females will be enrolled
• Patients present with the clinical picture of Major depression according to DSM 5 criteria.

Exclusion Criteria:

• Psychotic features associating depressive episode
• Bipolar depression
• The condition is due to another medical condition
• The condition is substance or medication-induced
• Intellectual disability
• Comorbid epilepsy

Study Plan

How is the study designed?

Number of groups / cohorts

2

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
Study Group (MDD with SIs); 25 Egyptian patients diagnosed with major depression (with suicidal ideations)	Diagnostic test: Quantitative EEG; Both groups will undergo evaluation of depression severity using Beck Depression Inventory Scale-II (Arabic Version); Both groups will be assessed for psychological & cognitive contributes respectively using:A. Connor and Davidson Scale for resilience (Arabic Version) B. The scale of Islamic Religiosity Attitude (SIRA); Both groups will do Quantitative EEG (qEEG) to detect electrical, functional and brain mapping changes {Using Neurovirtual BW III, Florida, USA); The quantitative analysis of EEG will focus on the following functions: Histogram, Topography, Spectrum Analysis, Spectral Differences, Propagation, Positional Diagram, Medium Amplitude, Ranges of Absolute Frequencies, Ranges of Relative Frequencies, CSA, Spectrum, and CSA Compressed.; Other Names: Resilience scale (Carl & Davidson) Arabic version; BDI (Beck Inventory II) Arabic version; Suicide probability Scale (Arabic Version); Scale of Islamic Religiosity Attitude (SIRA)
Control group (MDD without SIs); 25 Egyptian patients diagnosed with major depression (without suicidal ideations)	Diagnostic test: Quantitative EEG; Both groups will undergo evaluation of depression severity using Beck Depression Inventory Scale-II (Arabic Version); Both groups will be assessed for psychological & cognitive contributes respectively using:A. Connor and Davidson Scale for resilience (Arabic Version) B. The scale of Islamic Religiosity Attitude (SIRA); Both groups will do Quantitative EEG (qEEG) to detect electrical, functional and brain mapping changes {Using Neurovirtual BW III, Florida, USA); The quantitative analysis of EEG will focus on the following functions: Histogram, Topography, Spectrum Analysis, Spectral Differences, Propagation, Positional Diagram, Medium Amplitude, Ranges of Absolute Frequencies, Ranges of Relative Frequencies, CSA, Spectrum, and CSA Compressed.; Other Names: Resilience scale (Carl & Davidson) Arabic version; BDI (Beck Inventory II) Arabic version; Suicide probability Scale (Arabic Version); Scale of Islamic Religiosity Attitude (SIRA)

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Electrophysiological attibutes to suicide among depressed patients	Quantitative Analysis of EEG tracing from depressed patients experiencing suicidal Ideations	5 months

Collaborators and Investigators

• Sponsor: Mansoura University

Study record dates

Study Major Dates

• Study Start (Actual): October 1, 2019
• Primary Completion (Anticipated): July 15, 2020
• Study Completion (Anticipated): August 1, 2020

Study Registration Dates

• First Submitted: September 24, 2019
• First Submitted That Met QC Criteria: September 24, 2019
• First Posted (Actual): September 26, 2019

Study Record Updates

• Last Update Posted (Actual): April 28, 2020
• Last Update Submitted That Met QC Criteria: April 24, 2020
• Last Verified: April 1, 2020

More Information

Terms related to this study

• Keywords: Suicide; Major Depression; quantitative EEG (qEEG)
• Additional Relevant MeSH Terms: Behavioral Symptoms; Mental Disorders; Mood Disorders; Self-Injurious Behavior; Depressive Disorder; Suicide; Depressive Disorder, Major
• Other Study ID Numbers: MD.18.08.81

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: UNDECIDED
• IPD Plan Description: I am planning to include a foreigner supervisor on my thesis.

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No