- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03856775
Detecting Non-convulsive Seizures in the Paediatric Intensive Care Unit
Detecting Non-convulsive Seizures in the Paediatric Intensive Care Unit: A Pilot Study of Another Approach
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
Overall Goals: The overall goals of this research are to: (i) determine the feasibility of studying another approach to the detection of non-convulsive seizures in the paediatric intensive care unit, (ii) determine if paediatric intensive care nurses and non-neurophysiologist critical-care physicians can accurately identify seizures in critically ill children by reading quantitative EEG trends, as well as the positive and negative predictive value and inter-rater reliability of this approach, (iii) explore children's short- and long-term neurological outcomes.
Background: Non-convulsive seizures and non-convulsive status epilepticus are common in children with acute brain injury admitted to paediatric intensive care units. Electrographic seizure burden and status epilepticus contribute to neuronal injury, and worsen functional and quality of life outcomes. Accurate and timely diagnosis and treatment of non-convulsive seizures are essential in these critically ill children.
Purpose: This exploratory study aims to: (i) enable the investigators, after proof of concept, to assess the feasibility of this method, (ii) determine the performance - in real time at the bedside of critically ill children - of caregivers other than neurologists to identify electrographical seizures, using panels of quantitative EEG trends, and (iii) describe the outcome of these children.
Method: This pilot study will be a single-centre prospective open observational study. Thirty consecutive children who meet the specific criteria for continuous EEG in the paediatric intensive care unit at McMaster Children's Hospital will be eligible for enrolment. The paediatric intensive care nurse and resident or fellow will review the quantitative EEG trends to detect seizures at the bedside and complete the seizure log. This will be compared to the seizures detected on the raw EEG data read by the neurologist. Demographic data, baseline, short- and long-term (12-month) questionnaires of each child's global function, quality of life, seizures and brain behaviour will be completed to assess functional and quality of life outcomes. This will include a Seizure questionnaire, the Glasgow Outcome scale, the Paediatric Cerebral Performance Category score, the Paediatric Quality of Life Inventory, the Adaptive Behaviour Assessment System 3, the Child Behaviour Checklist and the Behaviour Rating Inventory of Executive Function 2.
Expertise: The investigator team includes research experts in neurology, epilepsy, neurophysiology, developmental paediatrics, critical care and biostatistics.
Significance: Due to the small numbers in this pilot study, the investigators are unlikely to be able to draw definitive conclusions on the clinical effects of this approach on the short- or long-term outcomes. This proof-of-concept study should enable the investigators to assess the feasibility of this method for a future multi-centre controlled study, which has the potential to revise and considerably improve the method of detecting non-convulsive seizures in the paediatric intensive care unit. If earlier detection and treatment of seizures in critically ill children are feasible, this should lead to improvements in short- and long-term neurological outcome and quality of life. These improvements may substantially benefit the person, family and society while reducing the burden placed on the health care system.
Study Type
Enrollment (Actual)
Contacts and Locations
Study Contact
- Name: Kevin Jones, MD FRCPC
- Phone Number: 75613 905 521 2100
- Email: joneskc@mcmaster.ca
Study Locations
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Ontario
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Hamilton, Ontario, Canada, L8S4K1
- McMaster Children's Hospital
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Sampling Method
Study Population
Description
Inclusion Criteria:
- Infants and children (1 month - 18 years of age)
- Admission to McMaster Children's Hospital paediatric intensive care unit.
- Fulfill indications for Continuous EEG monitoring
- Informed consent received
Exclusion Criteria:
- Suspected brain death
Study Plan
How is the study designed?
Design Details
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Patient recruitment,
Time Frame: 2 years
|
Will be analyzed based on descriptive statistics reported as an estimate of the 95 % confidence intervals.
This feasibility study will be considered successful if the rates of recruitment, are 0.8 with 95% confidence intervals of +/- 0.14.
|
2 years
|
Data form completion
Time Frame: 2 years
|
Will be analyzed based on descriptive statistics reported as an estimate of the 95 % confidence intervals.
This feasibility study will be considered successful if the data collection, is 0.8 with 95% confidence intervals of +/- 0.14.
|
2 years
|
Equipment availability
Time Frame: 2 years
|
Will be analyzed based on descriptive statistics reported as an estimate of the 95 % confidence intervals.
This feasibility study will be considered successful if the equipment availability is 0.8 with 95% confidence intervals of +/- 0.14.
|
2 years
|
Study completion
Time Frame: 2 years
|
Will be analyzed based on descriptive statistics reported as an estimate of the 95 % confidence intervals.
This feasibility study will be considered successful if the study-completion is 0.8 with 95% confidence intervals of +/- 0.14.
|
2 years
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Sensitivity
Time Frame: 2 years
|
The Sensitivity of quantitative electroencephalography read by intensive care nurses and non-neurology expert physicians - to detect electrographical seizures in the paediatric intensive care unit will be estimated against the standard method of seizure detection currently used by neurology experts with continuous electroencephalography.
|
2 years
|
Specificity
Time Frame: 2 years
|
The Specificity of quantitative electroencephalography read by intensive care nurses and non-neurology expert physicians - to detect electrographical seizures in the paediatric intensive care unit will be estimated against the standard method of seizure detection currently used by neurology experts with continuous electroencephalography.
|
2 years
|
Positive predictive value
Time Frame: 2 years
|
The positive predictive value of quantitative electroencephalography read by intensive care nurses and non-neurology expert physicians - to detect electrographical seizures in the paediatric intensive care unit will be estimated against the standard method of seizure detection currently used by neurology experts with continuous electroencephalography.
|
2 years
|
Negative predictive value
Time Frame: 2 years
|
The negative predictive value of quantitative electroencephalography read by intensive care nurses and non-neurology expert physicians - to detect electrographical seizures in the paediatric intensive care unit will be estimated against the standard method of seizure detection currently used by neurology experts with continuous electroencephalography.
|
2 years
|
Mortality
Time Frame: 1 year
|
The outcome of mortality, will be analyzed descriptively.
|
1 year
|
Glasgow Outcome scale
Time Frame: 1 year
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Higher values represent a worse outcome: 8 - Death, 7 - Vegetative State (VS), 6 - Lower Severe Disability (Lower SD), 5 - Upper Severe Disability (Upper SD), 4 - Lower Moderate Disability (Lower MD), 3 - Upper Moderate Disability (Upper MD), 2 - Lower Good Recovery (Lower GR) 1 - Upper Good Recovery (Upper GR). Will be analyzed descriptively. Estimations will be made with 95% confidence intervals. |
1 year
|
Pediatric Cerebral Performance Category score,
Time Frame: 1 year
|
Higher values represent a worse outcome: Normal -1 Mild disability -2 Moderate disability -3 Severe disability -4 Coma and vegetative state -5 Death -6.
Will be analyzed descriptively.
Estimations will be made with 95% confidence intervals.
|
1 year
|
Pediatric Quality of Life Inventory
Time Frame: 1 year
|
Will be analyzed descriptively.
Estimations will be made with 95% confidence intervals
|
1 year
|
Adaptive Behaviour Assessment System III,
Time Frame: 1 year
|
Will be analyzed descriptively.
Estimations will be made with 95% confidence intervals
|
1 year
|
Child Behaviour Checklist
Time Frame: 1year
|
Will be analyzed descriptively.
Estimations will be made with 95% confidence intervals
|
1year
|
Behaviour Rating Inventory of Executive Function II
Time Frame: 1 year
|
Will be analyzed descriptively.
Estimations will be made with 95% confidence intervals
|
1 year
|
Collaborators and Investigators
Sponsor
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- NIF-18448-R
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
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