- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT04262128
Sedentary Behavior in Older Women With and Without Type 2 Diabetes (SitWise)
Prolonged Sedentary Behavior in Older Women With and Without Type 2 Diabetes: Knowledge, Engagement, and Relationship to Cardiometabolic Risk
Study Overview
Status
Conditions
Detailed Description
The investigators will recruit 20 women age 60-75 years, n=10 with uncomplicated type 2 diabetes (T2D) and n=10 healthy controls. Participants will wear two accelerometers and a continuous glucose monitor (CGM) for two different periods of 7 days for objective assessment of physical activity, sedentary behavior, and blood glucose, respectively, and complete a graded exercise test (cardiorespiratory fitness), assessment of insulin sensitivity (hyperinsulinemic-euglycemic clamp) and single leg exercise using near-infrared spectroscopy (microvascular function). Participants will also complete a semi-structured qualitative interview to understand knowledge and attitudes toward sedentary behavior and questionnaires to assess the relationship between modifiable psychological and behavioral factors and sedentary behavior.
The aims of the study are to:
- Compare objectively-measured, free-living physical activity and sedentary behavior between older women with and without T2D.
- Evaluate the relationship between prolonged bouts of sedentary behavior, cardiorespiratory fitness, glucose control, insulin sensitivity, and skeletal muscle microvascular function in older women with and without T2D.
- Assess knowledge and attitudes toward sedentary behavior and characterize the relationship between knowledge and attitudes toward sedentary behavior and modifiable psychological and behavioral factors in older women with T2D.
- Evaluate the relationship between sedentary behavior, mood states, and meaning salience during "normal" life and the period of confinement imposed by the COVID-19 epidemic.
Study Type
Enrollment (Estimated)
Contacts and Locations
Study Contact
- Name: Mary O Whipple, PhD
- Phone Number: 303-724-2255
- Email: mary.whipple@cuanschutz.edu
Study Contact Backup
- Name: Deirdre Rafferty, MS
- Phone Number: 3037241331
- Email: deirdre.rafferty@gmail.com
Study Locations
-
-
Colorado
-
Aurora, Colorado, United States, 80045
- Recruiting
- University of Colorado Anschutz Medical Campus
-
Contact:
- Ethan Clark, MS
- Phone Number: 303-724-1354
- Email: ethan.w.clark@cuanschutz.edu
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Sampling Method
Study Population
Description
Inclusion Criteria:
- Female
- Age 60-75 years
- Postmenopausal (self-reported)
- BMI between 25-40 kg/m2
- Participants with T2D:
- T2D confirmed via chart review
- T2D diet controlled or treated with the following acceptable medication treatments: metformin, sulfonylureas, glinides, or glucose absorption blockers
Exclusion Criteria:
- Male
- Age <60 or >75 years
- Type 1 diabetes
- Control participants only - HbA1C ≥ 5.7%
- Use of beta blockers or centrally-acting calcium channel blockers (i.e., diltiazem, verapamil) due to potential blunting of cardiorespiratory fitness assessments
- Use of hormone replacement therapy (e.g., estrogen, progesterone, testosterone) (within the past 5 years)
- Taking insulin, thiazolidinediones (e.g., rosiglitazone), glucagon-like peptide-1 (GLP1) agonists (e.g., exenatide), dipeptidyl peptidase-4 (DPP4) inhibitors (e.g., sitagliptin) or any medication for the treatment of T2D other than those listed above in the inclusion criteria
- Uncontrolled hypertension at rest (systolic >160 or diastolic >110 mmHg)
- Obstructive pulmonary disease or asthma with a forced expiratory volume in 1 second (FEV1)/forced vital capacity (FVC) ratio <70% of predicted
- Any of the following conditions:
- Uncontrolled T2D (HbA1C >9.0%)
- Unstable angina
- Recent myocardial infarction, cardiac surgery, or vascular surgery (<3 months)
- Heart failure
- Peripheral artery disease (based on report of symptomatic claudication or ankle brachial index testing)
- Anemia (tHb <10 mg/dL)
- Hepatic or renal disease
- Severe arthritis or mobility impairment that would interfere with exercise testing
- Current tobacco or marijuana use or nicotine use within the last year
- Dementia or evidence of cognitive impairment (Mini-Cog score < 3)
- Engaging in >150 minutes/week of moderate to vigorous physical activity (assessed via Low-Level Physical Activity Recall questionnaire)
Study Plan
How is the study designed?
Design Details
Cohorts and Interventions
Group / Cohort |
---|
Type 2 Diabetes Mellitus
women age 60-75 years with uncomplicated type 2 diabetes mellitus
|
Healthy Controls
healthy women age 60-75 years
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
time sedentary measured via triaxial accelerometer
Time Frame: 7 days
|
7 days
|
|
average sedentary bout length measured via triaxial accelerometer
Time Frame: 7 days
|
7 days
|
|
cardiorespiratory fitness
Time Frame: 8-12 minutes
|
peak volume of oxygen consumption (VO2 peak) in ml/kg/min measured via graded exercise test
|
8-12 minutes
|
insulin sensitivity
Time Frame: 3 hours
|
glucose infusion rate in mg/kg/min as measured via hyperinsulinemic-euglycemic clamp
|
3 hours
|
change in skeletal muscle deoxygenated hemoglobin concentration during single leg calf exercise measured via near-infrared spectroscopy
Time Frame: 30 minutes
|
30 minutes
|
Collaborators and Investigators
Sponsor
Investigators
- Principal Investigator: Mary O Whipple, PhD, University of Colorado, Denver
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Estimated)
Study Completion (Estimated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 19-2758
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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