COVID - AirPollution

Air Pollution and COVID-19 Mortality in Geriatric Patients: a Multicenter Study

Epidemiological data have related particulate matter (PM), nitrogen dioxide (NO2) and ozone (O3) to COVID-19 morbidity and mortality at the population level. Air pollution may be related to an increase in the COVID-19 severity and lethality through its impact on chronic diseases such as cardiovascular and respiratory diseases and diabetes that are also the main comorbidities associated with COVID-19. Epidemiological studies using individual data are needed to provide more precise estimate of the association between air pollution exposure and COVID-19. In this multicenter prospective study, the investigators will analyze the number of deaths in COVID-19 confirmed cases in geriatric patients according to long-term exposure to air pollution, taking into account confounders such as diabetes, hypertension, age, and BMI. Exposure to air pollution will be estimated as the mean concentration of air pollutants at the residential address during the previous two years. In addition, the investigators will explore the relationship between short-term variations in air pollutants, relative humidity, temperature, UV radiations, pollen and the occurrence of COVID-19.

Study Overview

• Status: Completed
• Conditions: COVID-19 Confirmed Cases; COVID-19 Mortality

• Study Type: Observational
• Enrollment (Actual): 660

Contacts and Locations

Study Locations

• Belgium
  • Bruxelles, Belgium, 1090
    • Unité de neurologie-gériatrie, Hôpital Erasme, Cliniques Universitaires de Bruxelles
• France
  • Bischwiller, France, 67241
    • Unité de soins palliatifs gériatriques, Centre Hospitalier Départemental de Bischwiller
  • La Roche Sur Yon, France, 85925
    • Service de Gériatrie, Centre Hospitalier Départemental de Vendée
  • Nantes, France, 44093
    • Service de médecine aigüe gériatrique, Hôpital Nord Laennec, Hôpitaux Universitaires de Nantes
  • Paris, France, 75018
    • Service de Gériatrie, Hôpitaux Bichat et Bretonnaux, Assistance Publique des Hôpitaux de Paris
  • Reims, France, 51100
    • Service de Médecine Interne et Gériatrie, Hôpitaux Universitaires de Reims
  • Strasbourg, France, 67000
    • Service de Gériatrie, Hôpital de la Robertsau, Hôpitaux Universitaires de Strasbourg
  • Tours, France, 37044
    • Service de médecine gériatrique, Hôpitaux Universitaires de Tours

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 50 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

Patients admitted in geriatric departments between 2020/01/01 to 2020/06/01

Description

Inclusion Criteria:

• Patient over 60 years old (or dementia patient over 50 years old)
• Patient hospitalized in a geriatric department over the period from 2020/01/01 to 2020/06/01
• Patient who underwent RT-PCR SARS-CoV-2
• Patient (or trusted person/ legal guardian/curator, if applicable) who has given consent to the re-use of his/her data (patient data) for research purposes

Exclusion Criteria:

None

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
COVID-19 related-mortality	Association between COVID-19 related-mortality and air pollutants concentrations estimated at the residential address of geriatric patients during the last 2 years ( from 2018/01/01 to 2019/12/31)	COVID-19 mortality between 2020/01/01 and 2020/06/01

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
COVID-19 confirmed cases	Association between short- term variations in air pollutants, temperature, humidity, UV, pollens and the occurrence of COVID-19 confirmed cases. Short-term variations are defined as changes in air pollutants concentrations, temperature, humidity and pollen during the 20 days preceding the hospitalization.	COVID-19 confirmed cases between 2020/01/01 and 2020/06/01

Collaborators and Investigators

• Sponsor: University Hospital, Strasbourg, France
• Investigators: Principal Investigator: Frédéric BLANC, MD, Hôpitaux Universitaires de Strasbourg

Study record dates

Study Major Dates

• Study Start (Actual): June 4, 2020
• Primary Completion (Actual): June 1, 2021
• Study Completion (Actual): June 1, 2021

Study Registration Dates

• First Submitted: July 8, 2020
• First Submitted That Met QC Criteria: July 8, 2020
• First Posted (Actual): July 9, 2020

Study Record Updates

• Last Update Posted (Actual): June 25, 2021
• Last Update Submitted That Met QC Criteria: June 24, 2021
• Last Verified: June 1, 2021

More Information

Terms related to this study

• Keywords: COVID-19; Air pollution; Respiratory viral diseases; PM- NO2-Ozone
• Additional Relevant MeSH Terms: Coronavirus Infections; Coronaviridae Infections; Nidovirales Infections; RNA Virus Infections; Virus Diseases; Infections; Respiratory Tract Infections; Respiratory Tract Diseases; Pneumonia, Viral; Pneumonia; Lung Diseases; COVID-19
• Other Study ID Numbers: 7922

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No