- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT04624854
Dual Anti-Platelet Therapy in Patients With Coronary Multi-Vessel Disease (DAPT-MVD)
February 1, 2024 updated by: Yu Bo, Harbin Medical University
Dual Anti-Platelet Therapy in Patients With Coronary Multi-Vessel Disease (DAPT-MVD): A Prospective, Multicenter, Randomized, Controlled Trial
This study is a prospective, multicenter, parallel, open-label, randomized, controlled, superiority trial.
It is planned to recruit 8,250 patients with multi-vessel disease(MVD), and the patients will be followed-up for 12 months after being implanted with a drug-eluting stent (DES) at one of 100 different centers.
All patients will be randomly divided into the treatment group and control group on a 1:1 basis, based on a complete randomization.
Study Overview
Status
Recruiting
Conditions
Intervention / Treatment
Study Type
Interventional
Enrollment (Estimated)
8250
Phase
- Phase 4
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Contact
- Name: Jinwei Tian, M.D.,FACC
- Phone Number: +86 18545851107
- Email: tianjinweidr2009@163.com
Study Locations
-
-
Beijing
-
Beijing, Beijing, China, 101149
- Active, not recruiting
- Affiliated Beijing Luhe Hospital of Capital Medical University
-
-
Chongqing
-
Chongqing, Chongqing, China, 400042
- Recruiting
- The First Affiliated Hospital of Chongqing Medical University
-
Contact:
- Xiangsen Shao
- Phone Number: +8617316751907
- Email: 896862671@qq.com
-
Principal Investigator:
- Chunchang Qin, MD,PhD
-
Chongqing, Chongqing, China, 516562
- Recruiting
- the second affiliated hospital of Army medical university
-
Contact:
- Zhexue Qin
- Phone Number: +8615823810730
- Email: zhexueqin@126.com
-
Principal Investigator:
- Jun Jin, MD,PhD
-
-
Fujian
-
Fuzhou, Fujian, China, 350001
- Recruiting
- Fujian provincial hospital
-
Contact:
- Kaiyang Lin
- Phone Number: +8615622336793
- Email: 75345844@qq.com
-
Principal Investigator:
- Yansong Guo, MD,PhD
-
Xiamen, Fujian, China, 361101
- Recruiting
- Xiamen Fifth Hospital
-
Contact:
- Yandong Fu, MD,PhD
- Phone Number: +8619559247953
- Email: fyd00001@126.com
-
Principal Investigator:
- Yandong Fu, MD,PhD
-
-
Gansu
-
Qingyang, Gansu, China, 744517
- Recruiting
- Pingquan County Hospital
-
Contact:
- Yulian Zhang
- Phone Number: +8617725599881
- Email: pqxyyxnk@163.com
-
Principal Investigator:
- Jingchao Huang, MD,PhD
-
-
Guangdong
-
Guangzhou, Guangdong, China, 510700
- Recruiting
- The First Affiliated Hospital, Sun Yat-sen University
-
Contact:
- Chang Chen
- Phone Number: +8613100943501
- Email: chench295@mail2.sysu.edu.cn
-
Principal Investigator:
- Chen Liu, MD,PhD
-
Shenzhen, Guangdong, China, 518000
- Active, not recruiting
- Shenzhen People's Hospital
-
Zhongshan, Guangdong, China, 510080
- Recruiting
- Guangdong Provincial People's Hospital
-
Contact:
- Yibo He
- Phone Number: +8615603072684
- Email: heyibo2011@163.com
-
Principal Investigator:
- Yong Liu, MD,PhD
-
Zhongshan, Guangdong, China, 528406
- Active, not recruiting
- The Eighth Affiliated Hospital, Sun Yat-Sen University
-
-
Guangxi
-
Hezuo, Guangxi, China, 542800
- Recruiting
- Hezhou People's Hospital
-
Contact:
- Huahua Li
- Phone Number: +8619172521591
- Email: wu_jinjia@126.com
-
Principal Investigator:
- Jinjia Wu, MD,PhD
-
-
Guizhou
-
Zunyi, Guizhou, China, 563003
- Recruiting
- Affiliated Hospital of Zunyi Medical University
-
Contact:
- Xingwei Hu
- Phone Number: +8613246859061
- Email: hsingwii@163.com
-
Principal Investigator:
- Ranzun Zhao, MD,PhD
-
-
Hainan
-
Haikou, Hainan, China, 570208
- Recruiting
- Haikou People's Hospital
-
Contact:
- Hairong Liang
- Phone Number: +8618889524879
- Email: lhr4879@163.com
-
Principal Investigator:
- Miao Wu, MD,PhD
-
Haikou, Hainan, China, 570311
- Recruiting
- Hainan General Hospital
-
Contact:
- Wang Liao
- Phone Number: +8613518827831
- Email: crain_lw@163.com
-
Principal Investigator:
- Wang Liao, MD,PhD
-
Haikou, Hainan, China, 570311
- Recruiting
- The Second Affiliated Hospital of Hainan Medical University
-
Contact:
- Mengya Zeng
- Phone Number: +8615115568936
- Email: 249255971@qq.com
-
Principal Investigator:
- Yuewu Chen, MD,PhD
-
-
Hebei
-
Cangzhou, Hebei, China, 061014
- Recruiting
- Cangzhou Central Hospital
-
Contact:
- Guangren Gao
- Phone Number: +8618031792908
- Email: gaoguangren2004@163.com
-
Principal Investigator:
- Jun Zhang, MD,PhD
-
Chengde, Hebei, China, 067000
- Recruiting
- Affiliated Hospital of Chengde Medical University
-
Contact:
- Weichao Shan
- Phone Number: +8618503147606
- Email: 16442297@qq.com
-
Principal Investigator:
- Zhenjiang Ding, MD,PhD
-
Hengshui, Hebei, China, 053000
- Recruiting
- Harrison International Peace Hospital
-
Contact:
- Jiandong Xiao
- Phone Number: +8615031828120
- Email: xiaojiandong5188@163.com
-
Principal Investigator:
- Qun Zheng, MD,PhD
-
Shijiazhuang, Hebei, China, 052306
- Recruiting
- The Second Hospital of Hebei Medical University
-
Contact:
- Mingyue Rao
- Phone Number: +8613503212623
- Email: wangmei86632@sina.com
-
Principal Investigator:
- Mei Wang, MD,PhD
-
Principal Investigator:
- Guoqiang Gu, MD,PhD
-
Shijiazhuang, Hebei, China, 052360
- Recruiting
- The Third Hospital of Shijiazhuang
-
Contact:
- Chao Du
- Phone Number: +8613832172233
- Email: ssydcd@163.com
-
Principal Investigator:
- Lijun Wang, MD,PhD
-
Tangshan, Hebei, China, 063099
- Recruiting
- Tangshan Central Hospital
-
Contact:
- Tianhua Zhang
- Phone Number: +8618633397186
- Email: tianhuacsu@163.com
-
Principal Investigator:
- Jianong Xing, MD,PhD
-
Xingtai, Hebei, China, 054000
- Active, not recruiting
- The Second Affiliated Hospital of Xingtai Medical College
-
Xingtai, Hebei, China, 054000
- Active, not recruiting
- Xingtai Third Hospital
-
-
Heilongjiang
-
Daqing, Heilongjiang, China, 163001
- Recruiting
- Daqing Long Nan Hospital
-
Contact:
- Lei Cai, MD,PhD
- Phone Number: +8613504653780
- Email: 780mm@163.com
-
Principal Investigator:
- Lei Cai, MD,PhD
-
Daqing, Heilongjiang, China, 163316
- Active, not recruiting
- Daqing Oilfield general Hospital
-
Daqing, Heilongjiang, China, 163316
- Recruiting
- Daqing People's Hosipital
-
Contact:
- Xiaoyan Liu
- Phone Number: +8613845936110
- Email: lxy215@163.com
-
Principal Investigator:
- Shu Zhang, MD,PhD
-
Harbin, Heilongjiang, China, 150010
- Recruiting
- Harbin First Hospital
-
Contact:
- Rui Cao
- Phone Number: +8615776744113
- Email: 363557222@qq.com
-
Principal Investigator:
- Wanbin Zheng, MD,PhD
-
Principal Investigator:
- Jian Li, MD,PhD
-
Harbin, Heilongjiang, China, 150001
- Recruiting
- The Fourth Affiliated Hospital of Harbin Medical University
-
Contact:
- Yang Yu
- Phone Number: +8615846568703
- Email: zhijixin23@163.com
-
Principal Investigator:
- Jixin Zhi, MD,PhD
-
Harbin, Heilongjiang, China, 150030
- Recruiting
- Heilongjiang Province Hospital
-
Contact:
- Xuefeng Tian
- Phone Number: +8613009994672
- Email: tianxuefengsyy@163.com
-
Principal Investigator:
- Zheng Wang, MD,PhD
-
Harbin, Heilongjiang, China, 150056
- Recruiting
- Harbin Second Hospital
-
Contact:
- Hui Li
- Phone Number: +8613199489905
- Email: lele20080701@126.com
-
Principal Investigator:
- Guohua Zhang, MD,PhD
-
Harbin, Heilongjiang, China, 150066
- Recruiting
- Harbin 242 Hospital
-
Contact:
- Jiubin Sun
- Phone Number: +8613796016890
- Email: joe6890@163.com
-
Principal Investigator:
- Yin Zhou, MD,PhD
-
Harbin, Heilongjiang, China, 150086
- Recruiting
- The Second Affiliated Hospital of Harbin Medical University
-
Contact:
- Jinwei Tian, MD,PhD
- Phone Number: +8645186605180
- Email: Tianjinweidr2009@163.com
-
Principal Investigator:
- Bo Yu, MD,PhD
-
Harbin, Heilongjiang, China, 150088
- Recruiting
- The Second Cancer Hospital of Heilongjiang Province
-
Contact:
- Kexin Zhao
- Phone Number: +8615754519938
- Email: caopeigang@126.com
-
Principal Investigator:
- Peigang Cao, MD,PhD
-
Harbin, Heilongjiang, China, 150100
- Recruiting
- Shuangcheng People's Hospital
-
Contact:
- Xiaofeng Mei
- Phone Number: +8613836199982
- Email: 382648103@qq.com
-
Principal Investigator:
- Aiguo Sun, MD,PhD
-
Hegang, Heilongjiang, China, 154100
- Recruiting
- Hegang Mining Group General Hospital
-
Contact:
- Xiufu Li
- Phone Number: +8615545808255
- Email: 777353322@qq.com
-
Principal Investigator:
- Xiangli Shen, MD,PhD
-
Hegang, Heilongjiang, China, 154100
- Recruiting
- Hegang People's Hospital
-
Contact:
- Jing Yao
- Phone Number: +8618704686686
- Email: 103025271@qq.com
-
Principal Investigator:
- Xiangming Wang, MD,PhD
-
Hegang, Heilongjiang, China, 154211
- Recruiting
- Heilongjiang Provincial Agricultural Reclamation Baoquanling Administration Center Hospital
-
Contact:
- Jing liu
- Phone Number: +8613895922521
- Email: 147416596@qq.com
-
Principal Investigator:
- Jun Jiang, MD,PhD
-
Heihe, Heilongjiang, China, 161400
- Active, not recruiting
- Nenjiang People's Hospital
-
Jiamusi, Heilongjiang, China, 150086
- Recruiting
- The Central Hospital of Jiamusi City
-
Contact:
- Qi Zhang
- Phone Number: +8618249251087
- Email: zhangqi19840819@aliyun.com
-
Principal Investigator:
- Zhiyuan Weng, MD,PhD
-
Principal Investigator:
- Li Zhang, MD,PhD
-
Principal Investigator:
- Lianfeng Yang, MD,PhD
-
Principal Investigator:
- Shi Yin, MD,PhD
-
Jiamusi, Heilongjiang, China, 154002
- Recruiting
- The First Affiliated Hospital of Jamusi University
-
Contact:
- Ze Sun
- Phone Number: +8615694549908
- Email: gaoshan1963@sina.com
-
Principal Investigator:
- Shan Gao, MD,PhD
-
Jiamusi, Heilongjiang, China, 156300
- Recruiting
- The Jiansanjiang People's Hospital of Heilongjiang Land Reclamation
-
Contact:
- Jiaxin Shi
- Phone Number: +8613694549641
- Email: 414816268@qq.com
-
Principal Investigator:
- Shujiang Zhang, MD,PhD
-
Jixi, Heilongjiang, China, 158100
- Recruiting
- Jixi Jikuang Hospital
-
Contact:
- Zhenguo Xu
- Phone Number: +8613936266257
- Email: 357825046@qq.com
-
Principal Investigator:
- Dongmu Chai, MD,PhD
-
Jixi, Heilongjiang, China, 158100
- Recruiting
- Jixi People's Hospital
-
Contact:
- Bin Wang
- Phone Number: +8615146762150
- Email: bearsoon@126.com
-
Principal Investigator:
- Xibin Tan, MD,PhD
-
Mishan, Heilongjiang, China, 158300
- Recruiting
- Mishan People's Hospital
-
Contact:
- Zijun Guo
- Phone Number: +8613936266257
- Email: hsm6766@126.com
-
Principal Investigator:
- Shangmin Hu, MD,PhD
-
Mudanjiang, Heilongjiang, China, 157000
- Recruiting
- Mudanjiang City Second People's Hospital
-
Contact:
- Jinlong He
- Phone Number: +86113766664610
- Email: 68818591@qq.com
-
Principal Investigator:
- Xiaodong Ji, MD,PhD
-
Mudanjiang, Heilongjiang, China, 157011
- Recruiting
- Hongqi Hospital of Mudanjiang Medical University
-
Contact:
- Jiaoxia Yang
- Phone Number: +8613766590079
- Email: jiaoxiayang1977@163.com
-
Principal Investigator:
- Fengmin Gao, MD,PhD
-
Mudanjiang, Heilongjiang, China, 157011
- Recruiting
- Mudanjiang Cardiovascular Hospital
-
Contact:
- Shan Zhang
- Phone Number: +8618704537080
- Email: 40230303@qq.com
-
Principal Investigator:
- Kai Liu, MD,PhD
-
Principal Investigator:
- Lianmin Wang, MD,PhD
-
Mudanjiang, Heilongjiang, China, 157011
- Recruiting
- Mudanjiang First People's Hospital
-
Contact:
- Mingxia Han
- Phone Number: +8613845358606
- Email: hanmingxia2005@163.com
-
Principal Investigator:
- Mingxia Han, MD,PhD
-
Mudanjiang, Heilongjiang, China, 158322
- Recruiting
- Mudanjiang Administration Center Hospital of Heilongjiang Land Reclamation
-
Contact:
- Zhongfei Yu
- Phone Number: +8613836586642
- Email: 752277354@qq.com
-
Principal Investigator:
- Shufang Yin, MD,PhD
-
Qiqihar, Heilongjiang, China, 161000
- Recruiting
- Qiqihar Jianhua Hospital
-
Contact:
- Hongbo Tang
- Phone Number: +8613936266257
- Email: 113157362@163.com
-
Principal Investigator:
- Bo Jiang, MD,PhD
-
Qiqihar, Heilongjiang, China, 161000
- Recruiting
- The Third Affiliated Hospital of Qiqihar Medical University
-
Contact:
- Chunyu Jiang
- Phone Number: +8613904523434
- Email: xiaoyu7606@163.com
-
Principal Investigator:
- Yanxiang Shen, MD,PhD
-
Qiqihar, Heilongjiang, China, 161006
- Recruiting
- The First Affiliated Hospital of Qiqihar Medical University
-
Contact:
- Jia Liu
- Phone Number: +8613514644939
- Email: bingyuci2@126.com
-
Principal Investigator:
- Guiqing Liu, MD,PhD
-
Shuangyashan, Heilongjiang, China, 155100
- Recruiting
- Emergency General Hospital of Shuangyashan
-
Contact:
- Jie Zhao
- Phone Number: +8613555168891
- Email: hlc67108@163.com
-
Principal Investigator:
- Hui Li, MD,PhD
-
Shuangyashan, Heilongjiang, China, 155100
- Recruiting
- Shuangyashan People's Hospital
-
Contact:
- Wenjia Zhou
- Phone Number: +8613936266257
- Email: zhouwenjia198306@163.com
-
Principal Investigator:
- Feng Yu, MD,PhD
-
Shuangyashan, Heilongjiang, China, 155600
- Recruiting
- The People's Hospital of Baoqing
-
Contact:
- Yingying Sun
- Phone Number: +8613206783965
- Email: 122067727@qq.com
-
Principal Investigator:
- Yuchen Yuan, MD,PhD
-
Shuangyashan, Heilongjiang, China, 155811
- Recruiting
- Hongxinglong Central Hospital
-
Contact:
- Sirui Kang
- Phone Number: +8615146903103
- Email: 248606456@qq.com
-
Principal Investigator:
- Yuzhu Wang, MD,PhD
-
Suihua, Heilongjiang, China, 152053
- Recruiting
- Suihua First Hospital
-
Contact:
- Zhan Wang, MD,PhD
- Phone Number: +8613836433343
- Email: caihengzhihao@163.com
-
Principal Investigator:
- Hengzhi Cai, MD,PhD
-
Principal Investigator:
- Zhan Wang, MD,PhD
-
Xing'anling, Heilongjiang, China, 165000
- Recruiting
- Daxing'anling Prefecture People's Hospital
-
Contact:
- Juan Du
- Phone Number: +8613904570425
- Email: 271938499@qq.com
-
Principal Investigator:
- Dalei Qi, MD,PhD
-
Yichun, Heilongjiang, China, 152500
- Recruiting
- Tieli People's Hospital
-
Contact:
- Xin Li
- Phone Number: +8613936266257
- Email: 29334804@qq.com
-
Principal Investigator:
- Yanbo Niu, MD,PhD
-
Yichun, Heilongjiang, China, 153000
- Recruiting
- Yichun First Hospital
-
Contact:
- Zhenyu Yang
- Phone Number: +8613936266257
- Email: 13845858863@139.com
-
Principal Investigator:
- Daoye Zhang, MD,PhD
-
Yichun, Heilongjiang, China, 153000
- Recruiting
- Yichun Forestry Central Hospital
-
Contact:
- Hongyan Diao
- Phone Number: +8613766748268
- Email: LdJ9900@126.com
-
Principal Investigator:
- Dajun Li, MD,PhD
-
-
Henan
-
Kaifeng, Henan, China, 475001
- Recruiting
- Kaifeng Central Hospital
-
Contact:
- Shuai Zhang
- Phone Number: +8613592135892
- Email: ljy6051@126.com
-
Principal Investigator:
- Jieyun Liu, MD,PhD
-
Nanyang, Henan, China, 473004
- Recruiting
- Nanyang First People's Hospital
-
Contact:
- Fuqiang Sun
- Phone Number: +8618317227931
- Email: 1269878688@qq.com
-
Principal Investigator:
- Xiaorui Chen, MD,PhD
-
Nanyang, Henan, China, 473007
- Recruiting
- The First Affiliated Hospital of Nanyang Medical College
-
Contact:
- Hongwei Hu
- Phone Number: +8613598063182
- Email: 570135215@qq.com
-
Principal Investigator:
- Ou Zhang, MD,PhD
-
Puyang, Henan, China, 457000
- Recruiting
- Puyang People's Hospital
-
Contact:
- Jin Wang
- Phone Number: +8618639398168
- Email: 489329827@qq.com
-
Principal Investigator:
- Xuebin Chen, MD,PhD
-
Shangqiu, Henan, China, 476005
- Recruiting
- The First People's Hospital of Shangqiu
-
Contact:
- Shuai Li
- Phone Number: +8613603700359
- Email: lishenglisq@163.com
-
Principal Investigator:
- Shengli Li, MD,PhD
-
Shangqiu, Henan, China, 476610
- Recruiting
- Central Hospital of Yongcheng
-
Contact:
- Xuanxuan Peng
- Phone Number: +8615090551818
- Email: 15090551818@sina.cn
-
Principal Investigator:
- Qingye Cao, MD,PhD
-
Xinxiang, Henan, China, 453099
- Recruiting
- The Second People's Hospital of Xinxiang City
-
Contact:
- Ning Zhong
- Phone Number: +8618695915951
- Email: yjx840362@163.com
-
Principal Investigator:
- Jixia Yan, MD,PhD
-
Yongcheng, Henan, China, 476600
- Recruiting
- Yongcheng People's Hospital
-
Contact:
- Zhan Chen
- Phone Number: +8615239905101
- Email: 746507077@qq.com
-
Principal Investigator:
- Changming Tian, MD,PhD
-
Zhengzhou, Henan, China, 450016
- Recruiting
- The Seventh People's Hospital of Zhengzhou
-
Contact:
- Hua Zhang
- Phone Number: +8618236762366
- Email: 476228304@qq.com
-
Principal Investigator:
- Jing Li, MD,PhD
-
Principal Investigator:
- Jie Zhang, MD,PhD
-
Zhengzhou, Henan, China, 450052
- Recruiting
- The First Affiliated Hospital of Zhengzhou University
-
Contact:
- Yingying Zheng
- Phone Number: +8615214804944
- Email: jyzhang@zzu.edu.cn
-
Principal Investigator:
- Jinying Zhang, MD,PhD
-
Zhoukou, Henan, China, 477150
- Recruiting
- Dancheng People's Hospital
-
Contact:
- Yuhui Luo
- Phone Number: +8615333886060
- Email: 924229140@qq.com
-
Principal Investigator:
- Huanyu Guo, MD,PhD
-
-
Hubei
-
Wuhan, Hubei, China, 430030
- Active, not recruiting
- The Fourth Hospital of Wuhan
-
Wuhan, Hubei, China, 430060
- Active, not recruiting
- Renmin Hospital of Wuhan University
-
Wuhan, Hubei, China, 430062
- Active, not recruiting
- Zhongnan Hospital of Wuhan University
-
Yichang, Hubei, China, 443000
- Recruiting
- Yichang First People's Hospital
-
Contact:
- Huibo Wang
- Email: wanghuibo@whu.edu.cn
-
Principal Investigator:
- Jian Yang, MD,PhD
-
-
Hunan
-
Changsha, Hunan, China, 410013
- Recruiting
- The Third Xiangya Hospital of Central South University
-
Contact:
- Huiling Zhou
- Phone Number: +8615308425710
- Email: 13787318063@139.com
-
Principal Investigator:
- Yu Cao, MD,PhD
-
Hengyang, Hunan, China, 421001
- Recruiting
- The First Affiliated Hospital of University of South China
-
Contact:
- Jingjing Zhang
- Phone Number: +86 15873438571
- Email: 61052362@qq.com
-
Principal Investigator:
- Huifang Tang, MD,PhD
-
-
Jiangsu
-
Lianyungang, Jiangsu, China, 222002
- Recruiting
- The First People's Hospital of Lianyungang
-
Contact:
- Bo Zhao
- Phone Number: +8618961328797
- Email: zty8888@163.com
-
Principal Investigator:
- Bo Zhao, MD,PhD
-
Nanjing, Jiangsu, China, 210009
- Recruiting
- Zhongda Hospital Southeast University
-
Contact:
- Dan Huang
- Phone Number: +8615951903992
- Email: micheliafigo1116@163.com
-
Principal Investigator:
- Genshan Ma, MD,PhD
-
Pizhou, Jiangsu, China, 221300
- Recruiting
- Pizhou People's Hospital
-
Contact:
- Jianrong Yin
- Phone Number: +8615380118229
- Email: yjrpz@hotmail.com
-
Principal Investigator:
- Jianrong Yin, MD,PhD
-
-
Jiangxi
-
Fuzhou, Jiangxi, China, 344000
- Recruiting
- First People's Hospital of Fuzhou
-
Contact:
- Jincheng Li
- Phone Number: +8613699594198
- Email: 23155776@qq.com
-
Principal Investigator:
- Weiping He, MD,PhD
-
-
Jilin
-
Chang chun, Jilin, China, 130033
- Recruiting
- The Third Affiliated Hospital of Jilin University
-
Contact:
- Zhongyu Wang
- Phone Number: +8613596478561
- Email: 38236590@qq.com
-
Principal Investigator:
- Yuquan He, MD,PhD
-
Chang chun, Jilin, China, 130041
- Recruiting
- The Second Affiliated Hospital of Jilin University
-
Contact:
- He Wang
- Phone Number: +8615243120588
- Email: wanghe221@163.com
-
Principal Investigator:
- Bin Liu, MD,PhD
-
Changchun, Jilin, China, 130021
- Active, not recruiting
- Affiliated Hospital of Changchun Traditional Chinese Medicine University
-
Changchun, Jilin, China, 130021
- Recruiting
- The First Affiliated Hospital of Jilin University
-
Contact:
- Zhaoxi Liu
- Phone Number: +8613578981206
- Email: lzx620727@126.com
-
Principal Investigator:
- Qian Tong, MD,PhD
-
Jilin, Jilin, China, 132011
- Recruiting
- Jilin Central Hospital
-
Contact:
- Fangming Guo
- Phone Number: +8615043283490
- Email: 1409083977@qq.com
-
Principal Investigator:
- Ying Li, MD,PhD
-
Jilin, Jilin, China, 132012
- Recruiting
- Jilin Integrated Traditional Chinese and Western Medicine Hospital
-
Contact:
- Lei Wang
- Phone Number: +8618943207601
- Email: 156191841@qq.com
-
Principal Investigator:
- Jianping Shi, MD,PhD
-
Jilin, Jilin, China, 132022
- Active, not recruiting
- General Hospital of Jihua Group Company
-
Songyuan, Jilin, China, 138001
- Recruiting
- Songyuan Central Hospital
-
Contact:
- Jianguang Sun
- Phone Number: +8613843800120
- Email: Sigctshooer@163.com
-
Principal Investigator:
- Yi Zheng, MD,PhD
-
-
Liaoning
-
Dalian, Liaoning, China, 116011
- Recruiting
- The first affiliated hospital of dalian medical university
-
Contact:
- Yuxin Yang
- Phone Number: +86 18098871881
- Email: yangyuxinemc2@126.com
-
Principal Investigator:
- Bo Zhang, MD,PhD
-
Dalian, Liaoning, China, 116089
- Recruiting
- Dalian Municipal Cental Hospital
-
Contact:
- Lili Sun
- Phone Number: +8613889659272
- Email: 582632006@qq.com
-
Principal Investigator:
- Xiaoqun Zheng, MD,PhD
-
-
Neimeng
-
Hulunbeir, Neimeng, China, 021008
- Recruiting
- Hulunbeir People's Hospital
-
Contact:
- Jingyu Bai
- Phone Number: +8615149223192
- Email: wugang9700@126.com
-
Principal Investigator:
- Gang Wu, MD,PhD
-
Neimeng, Neimeng, China, 010017
- Recruiting
- Inner Mongolia People's Hospital
-
Contact:
- Xiaopeng Song
- Phone Number: +8615754930692
- Email: 1157714374@qq.com
-
Principal Investigator:
- Xi Liu, MD,PhD
-
-
Ningxia
-
Yinchuan, Ningxia, China, 750002
- Recruiting
- General Hospital of Ningxia Medical University
-
Contact:
- Xijuan Qi
- Phone Number: +8613995008241
- Email: 13909586860@139.com
-
Principal Investigator:
- Yumin Chou, MD,PhD
-
Principal Investigator:
- Xueping Ma, MD,PhD
-
-
Shandong
-
Fengcheng, Shandong, China, 271608
- Recruiting
- Feicheng Hospital of Shandong Guoxin Yiyang Group
-
Contact:
- Wenbo Zhang
- Phone Number: +8615288907118
- Email: bobowenz@163.com
-
Principal Investigator:
- Wenbo Zhang, MD,PhD
-
Jinan, Shandong, China, 250022
- Recruiting
- The Fifth People's Hospital of Jinan
-
Contact:
- Zhixin Su
- Phone Number: +8615866618392
- Email: jiazhisheng126@126.com
-
Principal Investigator:
- Zhisheng Jia, MD,PhD
-
Jinan, Shandong, China, 250031
- Recruiting
- Shandong Second Provincial General Hospital
-
Contact:
- Jianqin Feng, MD,PhD
- Phone Number: +8615090551818
- Email: 843128753@qq.com
-
Principal Investigator:
- Jianqin Feng, MD,PhD
-
Jinan, Shandong, China, 250031
- Recruiting
- The Fourth People's Hospital of Jinan
-
Contact:
- Hecheng Zhu
- Phone Number: +8613573780975
- Email: 937568489@qq.com
-
Principal Investigator:
- Tao Wang, MD,PhD
-
Jinan, Shandong, China, 250063
- Recruiting
- Qilu Hospital of Shandong University
-
Contact:
- Zhenguo Wu
- Phone Number: +8615098733691
- Email: yangjianmin@qiluhospital.com
-
Principal Investigator:
- Jianmin Yang, MD,PhD
-
Jining, Shandong, China, 272100
- Active, not recruiting
- Yanzhou District People's Hospital
-
Liaocheng, Shandong, China, 252699
- Recruiting
- The Second People's Hospital of Liaocheng
-
Contact:
- Yugang Zou
- Phone Number: +8613969554621
- Email: zyg052311@sina.com
-
Principal Investigator:
- Yugang Zou, MD,PhD
-
Tai'an, Shandong, China, 271099
- Recruiting
- Taian City Central Hospital
-
Contact:
- Wenju Yan
- Phone Number: +8618653876616
- Email: wishhy@163.com
-
Principal Investigator:
- Huanyi Zhang, MD,PhD
-
Principal Investigator:
- Jinlong Li, MD,PhD
-
-
Shanghai
-
Shanghai, Shanghai, China, 200032
- Recruiting
- Wusong hospital Affiliated Zhongshan Hospital of Fudan University
-
Contact:
- Mengshi Xie
- Phone Number: +8618846071232
- Email: shi-hy@hotmail.com
-
Principal Investigator:
- Hongyu Shi, MD,PhD
-
-
Shanxi
-
Xian, Shanxi, China, 710068
- Recruiting
- Shanxi Provincial People's Hospital
-
Contact:
- Nier Zhong
- Phone Number: +8613201790519
- Email: shouxiling@163.com
-
Principal Investigator:
- Xiling Shou, MD,PhD
-
-
Sichuan
-
Chongqing, Sichuan, China, 400000
- Withdrawn
- Xinqiao Hospital Army Medical University
-
Dazhou, Sichuan, China, 635099
- Recruiting
- Dazhou Central Hospital
-
Contact:
- Yi Li
- Phone Number: +8613558557692
- Email: 22491341@qq.com
-
Principal Investigator:
- Hualiang Gou, MD,PhD
-
-
Tianjin
-
Tianjin, Tianjin, China, 300052
- Recruiting
- Tianjin Medical University General Hospital
-
Contact:
- Shaopeng Xu
- Phone Number: +8613332093191
- Email: xsplzy@163.com
-
Principal Investigator:
- Qing Yang, MD,PhD
-
Tianjin, Tianjin, China, 300222
- Recruiting
- Tianjin Chest Hospital
-
Contact:
- Nan Zhang
- Phone Number: +8613502152283
- Email: fish7910@hotmail.com
-
Principal Investigator:
- Yin Liu, MD,PhD
-
Principal Investigator:
- Chunjie Li, MD,PhD
-
-
Xinjiang
-
Ürümqi, Xinjiang, China, 830001
- Recruiting
- Xinjiang Uiger Municipal People's Hospital
-
Contact:
- Zhao Wang
- Phone Number: +8613999806773
- Email: jzzqwz@163.com
-
Principal Investigator:
- Guoqing Li, MD,PhD
-
Ürümqi, Xinjiang, China, 830054
- Recruiting
- The First Affiliated Hospital of Xinjiang Medical University
-
Contact:
- Qian Zhao
- Phone Number: +8613899993630
- Email: myt-xj@163.com
-
Principal Investigator:
- Yitong Ma, MD,PhD
-
Principal Investigator:
- Xiang Xie, MD,PhD
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years to 75 years (Adult, Older Adult)
Accepts Healthy Volunteers
No
Description
Inclusion Criteria:
The enrolled subjects must meet all of the following criteria:
- Aged 18-75 years old (inclusive).
- Patients with MVD who underwent DES implantation for 12 months.
- Patients have been treated with aspirin and can tolerant of aspirin at doses of 75-150 mg/day as maintenance therapy during the study period.
- Patients have signed informed consent.
Exclusion Criteria:
- Subjects who meet any one of the following criteria are excluded from the study:
- Planned to use of ADP receptor blockers (eg, clopidogrel, ticagrelor, and ticlopidine), dipyridamole, or cilostazol.
- Contraindication to ADP receptor blockers or aspirin.
- Planned to use anticoagulants during the study period.
- Planned coronary, cerebrovascular, or peripheral arterial revascularization during the study period.
- Planned major cardiac or non-cardiac surgery during the study period.
- Concomitant oral or intravenous therapy with CYP2C19 medium or strong inhibitors.
- Known severe liver disease(ALT/AST is 3 times above normal).
- Subjects with renal failure who required or anticipated dialysis during the study period.
- Platelet count <50×10^9/L.
Patients with:
- A history of intracranial bleed or ischemic stroke at any time.
- A central nervous system tumor or intracranial vascular abnormality (eg, aneurysm, arteriovenous malformation) at any time.
- Intracranial or spinal cord surgery within 5 years.
- Pregnancy or lactation or planned to pregnant during the study period.
- Life expectancy < 1 year.
- Any condition which in the opinion of the investigator would make it unsafe or unsuitable for the patient to participate in this study (eg, active malignancy other than squamous cell or basal cell skin cancer).
- Concern for inability of the patient to comply with study procedures and/or followup (eg, alcohol or drug abuse).
- Participation in another clinical study and did not reach the major endpoint.
- Involvement in the planning and/or conduct of the study.
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Placebo Comparator: Aspirin monotherapy
Patients will receive aspirin monotherapy without co-administration of clopidogrel for 12 months after randomization.
|
Patients will receive aspirin monotherapy without co-administration of clopidogrel for 12 months after randomization.
|
Experimental: Clopidogrel and Aspirin dual-antiplatelet therapy
Patients will receive co-administration of clopidogrel and aspirin for 12 months after randomization.
|
Patients will receive co-administration of clopidogrel and aspirin for 12 months after randomization.
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Incidence of MACCE(cardiovascular death, nonfatal myocardial infarction or nonfatal stroke).
Time Frame: 12 months after randomization.
|
To evaluate the effect of Clopidogrel and Aspirin dual-antiplatelet therapy on the incidence of MACCE in patients with MVD
|
12 months after randomization.
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Incidence of all-cause mortality.
Time Frame: 12 months after randomization.
|
To evaluate the effect of Clopidogrel and Aspirin dual-antiplatelet therapy on the incidence of all-cause mortality in patients with MVD.
|
12 months after randomization.
|
Incidence of cardiovascular death.
Time Frame: 12 months after randomization.
|
To evaluate the effect of Clopidogrel and Aspirin dual-antiplatelet therapy on the incidence of cardiovascular death in patients with MVD.
|
12 months after randomization.
|
Incidence of nonfatal myocardial infarction.
Time Frame: 12 months after randomization.
|
To evaluate the effect of Clopidogrel and Aspirin dual-antiplatelet therapy on the incidence of nonfatal myocardial infarction in patients with MVD.
|
12 months after randomization.
|
Incidence of nonfatal stroke.
Time Frame: 12 months after randomization.
|
To evaluate the effect of Clopidogrel and Aspirin dual-antiplatelet therapy on the incidence of nonfatal stroke in patients with MVD.
|
12 months after randomization.
|
Incidence of clinical adverse events.
Time Frame: 12 months after randomization.
|
To evaluate the effect of Clopidogrel and Aspirin dual-antiplatelet therapy on the incidence of clinical adverse events (MACCE and BARC defined as type 2-5) in patients with MVD.
|
12 months after randomization.
|
Incidence of cardiovascular death or hospitalization.
Time Frame: 12 months after randomization.
|
To evaluate the effect of Clopidogrel and Aspirin dual-antiplatelet therapy on the incidence of cardiovascular death or hospitalization (myocardial infarction, stroke, emergency revascularization, unstable angina or TIA) caused by thrombotic events in patients with MVD.
|
12 months after randomization.
|
Incidence of emergency revascularization.
Time Frame: 12 months after randomization.
|
To evaluate the effect of Clopidogrel and Aspirin dual-antiplatelet therapy on the incidence of emergency revascularization in patients with MVD.
|
12 months after randomization.
|
Incidence of repeat revascularization.
Time Frame: 12 months after randomization.
|
To evaluate the effect of Clopidogrel and Aspirin dual-antiplatelet therapy on the incidence of any repeat revascularization in patients with MVD.
|
12 months after randomization.
|
Incidence of definite/possible stent thrombosis.
Time Frame: 12 months after randomization.
|
To evaluate the effect of Clopidogrel and Aspirin dual-antiplatelet therapy on the incidence of definite/possible stent thrombosis in patients with MVD.
|
12 months after randomization.
|
Other Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Incidence of clinically relevant bleeding events.
Time Frame: 12 months after randomization.
|
To evaluate the effect of Clopidogrel and Aspirin dual-antiplatelet therapy on the incidence of clinically relevant bleeding events (BARC, defined as type 2-5) in patients with MVD.
|
12 months after randomization.
|
Incidence of major bleeding events.
Time Frame: 12 months after randomization.
|
To evaluate the effect of Clopidogrel and Aspirin dual-antiplatelet therapy on the incidence of major bleeding events (BARC, defined as type3-5) in patients with MVD.
|
12 months after randomization.
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Investigators
- Principal Investigator: Bo Yu, M.D.,FACC, The Second Affiliated Hospital of Harbin Medical University
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
October 27, 2020
Primary Completion (Estimated)
April 30, 2025
Study Completion (Estimated)
April 30, 2025
Study Registration Dates
First Submitted
October 27, 2020
First Submitted That Met QC Criteria
November 5, 2020
First Posted (Actual)
November 12, 2020
Study Record Updates
Last Update Posted (Estimated)
February 2, 2024
Last Update Submitted That Met QC Criteria
February 1, 2024
Last Verified
February 1, 2024
More Information
Terms related to this study
Additional Relevant MeSH Terms
- Pathologic Processes
- Disease
- Heart Diseases
- Coronary Artery Disease
- Myocardial Ischemia
- Coronary Disease
- Cardiovascular Diseases
- Syndrome
- Vascular Diseases
- Arterial Occlusive Diseases
- Arteriosclerosis
- Acute Coronary Syndrome
- Physiological Effects of Drugs
- Neurotransmitter Agents
- Molecular Mechanisms of Pharmacological Action
- Peripheral Nervous System Agents
- Enzyme Inhibitors
- Analgesics
- Sensory System Agents
- Anti-Inflammatory Agents, Non-Steroidal
- Analgesics, Non-Narcotic
- Anti-Inflammatory Agents
- Antirheumatic Agents
- Fibrinolytic Agents
- Fibrin Modulating Agents
- Platelet Aggregation Inhibitors
- Cyclooxygenase Inhibitors
- Antipyretics
- Purinergic P2Y Receptor Antagonists
- Purinergic P2 Receptor Antagonists
- Purinergic Antagonists
- Purinergic Agents
- Aspirin
- Clopidogrel
Other Study ID Numbers
- DAPT-MVD-201912
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
UNDECIDED
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
product manufactured in and exported from the U.S.
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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