Study of Iron Accumulation Measured in MRI in Non-pathological Aging (FER-IRM)

To study the correlation between the iron load in brain, measured in MRI, and the age of healthy subjects Secondary objectives are to study the correlations between the iron load in cortical brain regions and (i) the cognitive performances, (ii) markers of aging (MRI, EEG, OCT, biology),and (iii) demographical factors involved in iron load.

Study Overview

• Status: Recruiting
• Conditions: Healthy Aging

• Study Type: Observational
• Enrollment (Estimated): 190

Contacts and Locations

• Study Contact: Name: Grégory KUCHCINSKI, MD; Phone Number: +33 0320445962; Email: gregory.kuchcinski@chru-lille.fr

Study Locations

• France
  • Lille, France, 59037
    • Recruiting
    • Hopital Roger Salengro, CHU Lille

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 95 years (Adult, Older Adult)
• Accepts Healthy Volunteers: Yes

• Sampling Method: Non-Probability Sample

Study Population

Healthy subjects from 18 to 95 years old stratified by sex and age groups

Description

Inclusion Criteria:

• Men or women between 18 and 95 years old
• French speaker with capability to understand the instructions
• Health insurance

Exclusion Criteria:

• Pregnancy
• minor subject
• no informed consent agreement
• subject enrolled in pharmaceutic study or exclusion period
• MRI contra-indications
• Neurological or psychiatric disorders
• MOCA < 26
• Psychotropic drugs
• More than 3 MRI exams
• More than 1 neuropsychological assessment (same cognitive tests) in the last 12 months
• Unable to follow the entire protocol according to the investigator

Study Plan

How is the study designed?

Number of groups / cohorts

1

Cohorts and Interventions

Group / Cohort
Healthy

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
Correlation coefficient between iron load in MRI and age	baseline

Collaborators and Investigators

• Sponsor: University Hospital, Lille
• Investigators: Principal Investigator: Grégory KUCHCINSKI, MD, University Hospital, Lille

Study record dates

Study Major Dates

• Study Start (Actual): January 30, 2023
• Primary Completion (Estimated): January 1, 2029
• Study Completion (Estimated): January 1, 2029

Study Registration Dates

• First Submitted: December 2, 2020
• First Submitted That Met QC Criteria: December 2, 2020
• First Posted (Actual): December 9, 2020

Study Record Updates

• Last Update Posted (Actual): May 29, 2025
• Last Update Submitted That Met QC Criteria: May 22, 2025
• Last Verified: May 1, 2025

More Information

Terms related to this study

• Other Study ID Numbers: 2019_24; 2020-A00491-38 (Other Identifier: ID-RCB number,ANSM)

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No
• product manufactured in and exported from the U.S.: No