The Effects of Different Montages of tDCS on Muscle Strength in Healthy Adults

June 19, 2022 updated by: Mahidol University

The Effects of Different Montages of Transcranial Direct Current Stimulation on Muscle Strength in Healthy Adults

To investigate the effects of different montages of tDCS on muscle strength in healthy adults

Study Overview

Status

Completed

Conditions

Detailed Description

Electrode montage or placement of tDCS over primary motor cortex can be categorized into unilateral (anodal or cathodal electrode over primary motor area) and bilateral tDCS (both anodal and cathodal electrode over the cortex). Previous studies reported benefits of different tDCS montages on muscle performance in healthy participants. However, there is no guideline for tDCS montages. This study aims to investigate immediate effects of different tDCS montages on muscle strength in healthy participants.

Study Type

Interventional

Enrollment (Actual)

80

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

    • Nakhon Pathom
      • Salaya, Nakhon Pathom, Thailand, 73170
        • Faculty of Physical Therapy, Mahidol University

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years to 60 years (Adult)

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Description

Inclusion Criteria:

  1. Healthy adults
  2. Age range between 18 - 60 years old
  3. Right-handed dominant identified by the Edinburg Handedness Inventory
  4. No recent muscle injuries of both limbs for a past 6-months

Exclusion Criteria:

  1. Consumed caffeine within 24 hours prior the experiment
  2. History of neurological symptoms i.e. seizures, weakness, loss of sensation or unclear history of pass illness
  3. Present of metal implantation, intracranial shunt, cochlear implantation or cardiac pacemakers
  4. Present of opened wound or infectious wound around scalp

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Factorial Assignment
  • Masking: Triple

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: Anodal-tDCS
Anodal transcranial direct current stimulation (tDCS) will be applied for 20 mins. Anode on the primary motor area (M1) of dominant hemisphere and Cathode on the supraorbital area of non-dominant hemisphere. Current intensity is fixed at 2 mA and current will flow continuously. The scope of intervention is to investigate effect of tDCS on muscle strength.
Dual/Cathodal/Anodal/Sham tDCS will be applied in 2 mA, 20 mins. All experiments will be performed in random order for each subject.
Experimental: Cathodal-tDCS
Cathodal transcranial direct current stimulation (tDCS) will be applied for 20 mins. Cathode on the primary motor area (M1) of non-dominant hemisphere and Anode on the supraorbital area of dominant hemisphere. Current intensity is fixed at 2 mA and current will flow continuously. The scope of intervention is to investigate effect of tDCS on muscle strength.
Dual/Cathodal/Anodal/Sham tDCS will be applied in 2 mA, 20 mins. All experiments will be performed in random order for each subject.
Experimental: Dual-tDCS
Dual transcranial direct current stimulation (tDCS) will be applied for 20 mins. Anode on the primary motor area (M1) of dominant hemisphere and Cathode on the primary motor area of non-dominant hemisphere. Current intensity is fixed at 2 mA and current will flow continuously. The scope of intervention is to investigate effect of tDCS on muscle strength.
Dual/Cathodal/Anodal/Sham tDCS will be applied in 2 mA, 20 mins. All experiments will be performed in random order for each subject.
Sham Comparator: Sham-tDCS
Dual transcranial direct current stimulation (tDCS) will be applied over C3-C4 or the motor area (M1) for 20 mins. Anode on dominant hemisphere, Cathode on non-dominant hemisphere. The scope of intervention is to investigate effect of tDCS on muscle strength.
Dual/Cathodal/Anodal/Sham tDCS will be applied in 2 mA, 20 mins. All experiments will be performed in random order for each subject.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Change from baseline muscle strength after tDCS
Time Frame: Baseline (Pretest) and 40 minutes ( posttest)
Muscle strength will be measured in Newton by using a hand-held dynamometer.
Baseline (Pretest) and 40 minutes ( posttest)

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

November 16, 2020

Primary Completion (Actual)

May 31, 2022

Study Completion (Actual)

May 31, 2022

Study Registration Dates

First Submitted

December 9, 2020

First Submitted That Met QC Criteria

December 16, 2020

First Posted (Actual)

December 17, 2020

Study Record Updates

Last Update Posted (Actual)

June 22, 2022

Last Update Submitted That Met QC Criteria

June 19, 2022

Last Verified

June 1, 2022

More Information

Terms related to this study

Other Study ID Numbers

  • MU2020

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

No

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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