Incidence of Different Surgical Technics for Colorectal Deep Infiltrating EndoMetriosis on the Post-operative Fertility and Pregnancy Outcomes (Endo-Metrios)

Endometriosis is a disease that is very present on the current media scene. Its symptoms are very nonspecific and numerous. (dysmenorrhea, dyspareunia, dyschezia, urinary functional signs, infertility, chronic pelvic pain, etc.) Its prevalence is estimated at 10% of women and 20% of them have deep pelvic endometriosis. Colorectal lesions involving the rectosigmoid junction and the rectum represent the most severe forms and affect 5.3 to 12% of patients with deep pelvic endometriosis. Endometriosis is found in 20 to 50% of patients consulting for infertility and the rate of spontaneous pregnancy in patients with deep endometriosis is estimated to be between 8.7 and 13%. Surgery appears to improve fertility in women. However, several surgical techniques for deep endometriosis at the digestive level have been described, conservative or radical, without any having demonstrated its superiority both in terms of symptoms and fertility.

The aim of this study was to evaluate the incidence of different surgical technics (shaving vs. bowel resection) on post-operative fertility among patients with bowel deep infiltrating endometriosis and the pregnancy outcome

Study Overview

• Status: Completed
• Conditions: Endometriosis

• Study Type: Observational
• Enrollment (Actual): 164

Contacts and Locations

Study Locations

• France
  • Strasbourg, France, 67091
    • Department of Gynecology - Strasbourg University Hospitals

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (ADULT, OLDER_ADULT)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: Female

• Sampling Method: Non-Probability Sample

Study Population

Adult woman with a desire to become pregnant and who had undergone surgery for the management of deep digestive endometriosis between September 01, 2009 and October 31, 2016.

Description

Inclusion Criteria:

• Adult woman (≥18 years old).
• woman with a desire to become pregnant and who had undergone surgery for the management of deep digestive endometriosis between September 01, 2009 and October 31, 2016.
• Woman who has not expressed, after information, the reuse of her data for the purposes of this research.

Exclusion Criteria:

• Woman who expressed her opposition to participating in the study
• Woman who had undergone a surgical intervention for the management of deep digestive endometriosis between September 01, 2009 and October 31, 2016 and having no desire to become pregnant
• Woman under safeguard of justice
• Woman under guardianship or guardianship

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
Retrospective analysis of the rate of occurrence of pregnancy postoperatively.	Files analysed retrospectily from September 1st, 2009 to October 31, 2016 will be examined

Collaborators and Investigators

• Sponsor: University Hospital, Strasbourg, France
• Investigators: Study Director: Émilie FALLER, Department of Gynecology - Strasbourg University Hospitals

Study record dates

Study Major Dates

• Study Start (ACTUAL): December 30, 2020
• Primary Completion (ACTUAL): November 30, 2021
• Study Completion (ACTUAL): December 31, 2021

Study Registration Dates

• First Submitted: December 18, 2020
• First Submitted That Met QC Criteria: December 18, 2020
• First Posted (ACTUAL): December 23, 2020

Study Record Updates

• Last Update Posted (ACTUAL): January 31, 2022
• Last Update Submitted That Met QC Criteria: January 25, 2022
• Last Verified: November 1, 2020

More Information

Terms related to this study

• Keywords: fertility; colorectal endometriosis; deep infiltrating endometriosis; surgical technics in endometriosis
• Additional Relevant MeSH Terms: Endometriosis
• Other Study ID Numbers: 8088

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No