- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT04751032
Chinese Nutritional Risk Screening and Intervention Registration Study in Geriatric Patients (CNRSIS)
March 14, 2021 updated by: Chinese Medical Association
This study is a multi-center observational study, led by the Department of Geriatrics, Peking Union Medical College Hospital, with 99 tertiary hospitals as sub-centers.
Patients in the geriatrics department from September 2020 to September 2021 are consecutively enrolled .Basic information and nutritional risk assessment is registered and the outcome within 90 days after hospitalization will be recorded.Daily energy, protein and fiber are 75% of the target amount as the standard for feeding.
Study Overview
Status
Unknown
Conditions
Detailed Description
This study is a multi-center observational study.Patients in the geriatrics department from September 2020 to September 2021 are consecutively enrolled .The patients' basic information, nutritional assessment, diet and blood biochemical indicators after hospitalization will be registered.The status of nutritional treatment and rehabilitation training and whether there is any adverse outcome when discharged from the hospital will be recorded.
Daily energy, protein and fiber are 75% of the target amount as the standard for feeding.The diet, exercise status and adverse outcomes of participants within 90 days after hospitalization will be followed up through outpatient, telephone or remote consultation.Primary endpoint-the impact of nutritional therapy (energy, protein, dietary fiber compliance or failure) on mortality, new infections, falls and readmissions in elderly hospitalized patients within 90 days after hospitalization; secondary endpoints-the change of the nutrition indicators, the physical function and quality of life of the participants within 90 days after hospitalization.
Study Type
Observational
Enrollment (Anticipated)
2000
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
Beijing
-
Beijing, Beijing, China, 100730
- Recruiting
- Department of Geriatrics,Peking Union Medical College Hospital
-
Contact:
- Xiaohong Liu, MD &PHD
- Phone Number: 18610003310
- Email: xhliu41@sina.com
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
65 years and older (Older Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Sampling Method
Non-Probability Sample
Study Population
Patients in the geriatrics/geriatrics department of tertiary hospitals from September 2020 to September 2021 are consecutively enrolled.
Description
Inclusion Criteria:
- Patients aged ≥65 years old in geriatrics;
- Expected hospitalization ≥4 days;
- Patients with NRS 2002≥3 points;
- Sign informed notice.
Exclusion Criteria:
- End-stage patients (estimated survival time ≤ 3 months);
- Transfer to other departments during hospitalization;
- Contraindications to nutritional therapy (such as hemodynamic instability);
- Have participated in other nutritional research projects.
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Rate of mortality
Time Frame: within 90 days after hospitalization
|
all cause mortality
|
within 90 days after hospitalization
|
Number of Participants with respiratory, urinary or gastrointestinal infections diagnosed by clinicians
Time Frame: within 90 days after hospitalization
|
Any infection diagnosed by a formal medical institution.Infections that require a doctor's prescription of antibiotics indicated in the medical records or diagnosis reports provided by the participants, including the respiratory tract, urinary tract, gastrointestinal tract, etc.The report or diagnosis certificate has relevant evidence, for example, the test indicates that the white blood cell is increased or the high-sensitivity C-reactive protein is increased.
|
within 90 days after hospitalization
|
Number of Participants with unplanned hospitalization for acute illness
Time Frame: within 90 days after hospitalization
|
Visits reported by participants because of an acute illness rather than regular visits.Hospital stays longer than 48 hours will be counted, but outpatient visits will not be counted.
|
within 90 days after hospitalization
|
Number of Participants with fall
Time Frame: within 90 days after hospitalization
|
Any falls reported by the participants within 90 days will be recorded.
The cause of the fall and whether it is accompanied by a fracture shall be recorded.
|
within 90 days after hospitalization
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Number of Participants with the albumin changes
Time Frame: Within 90 days after hospitalization
|
The albumin level of the 90-day follow-up and baseline will be measured in the unified laboratory using the same monitoring method, and the changes are used as the evaluation index of nutrition
|
Within 90 days after hospitalization
|
Number of Participants with the physical function changes assessed by katz activity of the daily living(ADL)
Time Frame: Within 90 days after hospitalization
|
The Katz scale goes by the basics to evaluate a patient's level of independence or dependence.The 90-day follow-up and baseline ADL scores will be evaluated by trained elderly doctors, and the changes are used as the evaluation indicators for functional changes
|
Within 90 days after hospitalization
|
Number of Participants with the quality of the life changes according to the EuroQol Five Dimensions Questionnaire(EQ-5D)
Time Frame: Within 90 days after hospitalization
|
the change of the score of the EQ-5D assessed by the participants.EQ-5D, EuroQol Five Dimensions Questionnaire, is a set of standardized scales for measuring health status.
EQ-5D was developed by the European Society for Quality of Life (EuroQol), which can provide a simple and universal health measurement method.
In the description part, five dimensions will be used to describe the health status.
The five dimensions are: Mobility, Self-care, Usual Activities, Pain/Discomfort ), Anxiety/Depression.
The questionnaire requires respondents to choose the most suitable option in each dimension according to their health status.
|
Within 90 days after hospitalization
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Investigators
- Principal Investigator: Xiaohong Liu, MD &PHD, Department of Geriatrics,Peking Union Medical College Hospital
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
September 1, 2020
Primary Completion (Anticipated)
December 31, 2021
Study Completion (Anticipated)
December 31, 2021
Study Registration Dates
First Submitted
January 23, 2021
First Submitted That Met QC Criteria
February 9, 2021
First Posted (Actual)
February 11, 2021
Study Record Updates
Last Update Posted (Actual)
March 17, 2021
Last Update Submitted That Met QC Criteria
March 14, 2021
Last Verified
October 1, 2020
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- NCT2020090120210601
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
NO
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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