Influence of Square-stepping Exercise on Brain Activation, Cognitive Function and Physical Performance in Frail Elders With MCI

This study is to elucidate the possible mechanisms of SSE by examining brain activation differences between SSE patterns and usual walking, as well as the relationship between brain activity and SSE performance, between cognitive function and SSE performance, and between physical performance and SSE performance in frail elders with MCI.

Study Overview

• Status: Recruiting
• Conditions: Frailty; Mild Cognitive Impairment

Detailed Description

Background:

Both frailty and MCI exert negative impact on motor and cognitive function, which increase the risks of fall and adverse health condition. SSE has been proved to be an effective intervention for motor and cognitive function in older adults. However, the underlying mechanisms of SSE still remain undetermined for its possible effects. This study aims to elucidate the possible mechanisms of SSE in frail elders with MCI.

Methods:

This is a cross-sectional study. The inclusion criteria are: (1) age between 65 and 90 years old, (2) the presence of at least 1 characteristic of the Fried frailty criteria, (3) with mini-mental state examination (MMSE) score≧24 and Montreal Cognitive Assessment (MoCA) score <26 (MCI criteria), and (4) ability to walk independently for 1 min without assistive devices. The exclusion criteria are: (1) central nervous system disorders (such as stroke, Parkinson's disease, spinal cord injury), and (2) any unstable physical condition, psychiatric disorder, and other neurological disorder or diagnosed with learning disability which may affect participating this study. Brain activity during SSE and usual walking, SSE performance, physical performance, and cognitive function are measured. The purpose of this study is to elucidate the possible mechanisms of SSE by examining brain activation differences between SSE patterns and usual walking, as well as the relationship between brain activity and SSE performance, between cognitive function and SSE performance, and between physical performance and SSE performance in frail elders with MCI.

• Study Type: Observational
• Enrollment (Anticipated): 30

Contacts and Locations

• Study Contact: Name: Ray-Yau Wang, PhD; Phone Number: +886-2-28267210; Email: rywang@nycu.edu.tw

Study Locations

• Taiwan
  • Taipei, Taiwan, 112
    • Recruiting
    • National Yang Ming Chiao Tung University
    • Contact: Ray-Yau Wang, PhD; Phone Number: +886-2-28267210; Email: rywang@nycu.edu.tw

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 65 years to 90 years (Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

Older adults with frailty and mild cognitive impairment

Description

Inclusion Criteria:

• Age between 65 and 90 years old
• Presence of at least 1 characteristic of the Fried frailty criteria
• Mini-mental state examination score equal to or more than 24
• Montreal Cognitive Assessment score less than 26
• Ability to walk independently for 1 min without assistive devices

Exclusion Criteria:

• Central nervous system disorders (such as stroke, Parkinson's disease, spinal cord injury)
• Any unstable physical condition, psychiatric disorder, and other neurological disorder or diagnosed with learning disability which may affect participating this study

Study Plan

How is the study designed?

Design Details

• Observational Models: Other
• Time Perspectives: Cross-Sectional

Number of groups / cohorts

1

Cohorts and Interventions

Group / Cohort
Older adults with frailty and mild cognitive impairment

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Brain activity	The brain activity will be measured under 3 tasks: usual walking, SSE-pattern1 (SSE1), and SSE-pattern 2 (SSE2)	20 minutes
SSE performance	The number of the correct steps that participants complete in 1 min during SSEs will be recorded	15 minutes
Montreal Cognitive Assessment	Global cognitive function	15 minutes
Trail making test	Executive function	5 minutes
Stroop color and word test	Executive function	5 minutes
Digit span test	Executive function	8 minutes
Timed up and go test	Dynamic balance and functional mobility	5 minutes
Berg balance scale	Balance and fall risk	15 minutes
Five times sit to stand test	Lower extremity strength	3 minutes

Collaborators and Investigators

• Sponsor: National Yang Ming University

Study record dates

Study Major Dates

• Study Start (Actual): February 9, 2022
• Primary Completion (Anticipated): December 31, 2023
• Study Completion (Anticipated): December 31, 2023

Study Registration Dates

• First Submitted: December 5, 2021
• First Submitted That Met QC Criteria: December 20, 2021
• First Posted (Actual): December 29, 2021

Study Record Updates

• Last Update Posted (Actual): October 14, 2022
• Last Update Submitted That Met QC Criteria: October 12, 2022
• Last Verified: September 1, 2022

More Information

Terms related to this study

• Keywords: Mild Cognitive Impairment; Frailty; Square-stepping exercise
• Additional Relevant MeSH Terms: Mental Disorders; Pathologic Processes; Neurocognitive Disorders; Cognition Disorders; Cognitive Dysfunction; Frailty
• Other Study ID Numbers: YM110152F

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: No

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No