Locked-in Syndrome Caused by Pulmonary Arteriovenous Malformation: A Case Report

In this case, we report a case of atresia syndrome (LIS), a serious neurological disease caused by pulmonary arteriovenous fistula (PAVM). We present a previously healthy middle-aged woman who developed atresia syndrome after severe pontine infarction due to basilar artery occlusion due to undiagnosed arteriovenous malformation. This report reviewed the medical history, post-admission examination and related literature, and concluded that PAVM should be considered as the cause of implicit stroke, especially in young patients with right-to-left shunt, and should be actively treated.

Study Overview

• Status: Recruiting
• Conditions: Locked-In Syndrome；Pulmonary Arteriovenous Malformation
• Intervention / Treatment: Other: In this study, only cases were collected and reported without any intervention or adverse reactions

• Study Type: Observational
• Enrollment (Anticipated): 1

Contacts and Locations

• Study Contact: Name: hao wang, master; Phone Number: +8615968891667; Email: 2519160@zju.edu.cn
• Study Contact Backup: Name: le zhang, master; Phone Number: +8613616511229; Email: 2319053@zju.edu.cn

Study Locations

• China
  • Hangzhou, China
    • Recruiting
    • 2nd Affiliated Hospital, School of Medicine, Zhejiang University, China
    • Contact: hao wang, master; Phone Number: +86 15968891667; Email: 2519160@zju.edu.cn
    • Contact: le zhang, master; Phone Number: +86 13616511229; Email: 2319053@zju.edu.cn

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: ADULT; OLDER_ADULT; CHILD
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

A patient with locked-in syndrome

Description

Inclusion Criteria:

• A case of Locked-in syndrome due to pulmonary arteriovenous malformation

Exclusion Criteria:

• Patients or family members objected to the study

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Locked-in syndrome caused by pulmonary arteriovenous malformation . Check list report	A recommendation is made for the treatment and prognosis of patients with severe atresia caused by arteriovenous fistula.	1month

Collaborators and Investigators

• Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University

Study record dates

Study Major Dates

• Study Start (ACTUAL): October 1, 2021
• Primary Completion (ANTICIPATED): June 2, 2022
• Study Completion (ANTICIPATED): June 2, 2022

Study Registration Dates

• First Submitted: April 10, 2022
• First Submitted That Met QC Criteria: April 26, 2022
• First Posted (ACTUAL): April 27, 2022

Study Record Updates

• Last Update Posted (ACTUAL): April 27, 2022
• Last Update Submitted That Met QC Criteria: April 26, 2022
• Last Verified: October 1, 2021

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Pathologic Processes; Cardiovascular Diseases; Vascular Diseases; Nervous System Diseases; Neoplasms by Histologic Type; Neoplasms; Neurologic Manifestations; Disease; Neuromuscular Diseases; Pathological Conditions, Anatomical; Cardiovascular Abnormalities; Neoplasms, Vascular Tissue; Vascular Malformations; Paralysis; Vascular Fistula; Fistula; Syndrome; Congenital Abnormalities; Hemangioma; Arteriovenous Malformations; Quadriplegia; Arteriovenous Fistula; Locked-In Syndrome
• Other Study ID Numbers: 2022-0138

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No