Effects of Combinations of Performance-enhancing Supplements on Exercise Performance

August 11, 2022 updated by: Morten Hostrup, PhD

Effects of Different Combinations of Performance-enhancing Supplements on High Intensity Exercise Performance

The purpose of the study is to investigate the effect of combinations of creatine monohydrate, sodium bicarbonate and caffeine on exercise performance and fatigability.

Study Overview

Status

Active, not recruiting

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Actual)

23

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Denmark
      • Copenhagen, Denmark, 2100
        • August Krogh Building

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years to 45 years (Adult)

Accepts Healthy Volunteers

Yes

Genders Eligible for Study

All

Description

Inclusion Criteria:

  • Healthy
  • VO2max of >50 ml/min/kg for men and >45 ml/min/kg for women
  • Performs endurance training >3 times per week

Exclusion Criteria:

  • Chronic disease deemed by the study responsible medical doctor to interfere with any part of the study
  • Smoking
  • Chronic use of prescription medicine deemed by the study responsible medical doctor to interfere with any part of the study

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Basic Science
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Quadruple

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: Creatine
Subjects ingest creatine monohydrate daily.
Dietary supplement: Sodium bicarbonate and caffeine
On experimental days subjects ingest a combination of sodium bicarbonate, caffeine and placebo.
Placebo Comparator: Placebo
Subjects ingest placebo daily.
Dietary supplement: Sodium bicarbonate and caffeine
On experimental days subjects ingest a combination of sodium bicarbonate, caffeine and placebo.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Work performed (kJ/Watt)
Time Frame: Measured at each trial throughout the study, on average 4 weeks
Work performed during a 6 minute time trial
Measured at each trial throughout the study, on average 4 weeks

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Work performed (kJ/Watt)
Time Frame: Measured at each trial throughout the study, on average 4 weeks
Work performed during a 15 second sprint test
Measured at each trial throughout the study, on average 4 weeks
Muscle strength (Nm)
Time Frame: Measured at each trial throughout the study, on average 4 weeks
Maximal voluntary isometric contraction of m. quadriceps femoris
Measured at each trial throughout the study, on average 4 weeks

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Morten Hostrup, PhD

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

April 18, 2022

Primary Completion (Anticipated)

March 1, 2023

Study Completion (Anticipated)

December 1, 2023

Study Registration Dates

First Submitted

April 18, 2022

First Submitted That Met QC Criteria

April 25, 2022

First Posted (Actual)

May 2, 2022

Study Record Updates

Last Update Posted (Actual)

August 12, 2022

Last Update Submitted That Met QC Criteria

August 11, 2022

Last Verified

August 1, 2022

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • COCKTAIL

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

UNDECIDED

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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