Effect of Iodine Deficiency on Periodontitis

February 2, 2023 updated by: Didem OZKAL EMINOGLU, Ataturk University

The goal of this observational study is to compare urine iodine levels of participants with/without periodontitis.

The main question it aims to answer is there a relationship between iodine levels of urine and periodontitis.

Participants will give urine samples without any intervention.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

Periodontitis is a chronic, inflammatory disease with a cyclical course with active and passive periods, which may result in the destruction of gingival fibers, resorption of alveolar bone, and subsequent tooth loss, by spreading the inflammatory event that started in the gingiva to the tissues supporting the tooth as a result of the effects of bacteria. The disease is closely associated with many systemic conditions. These conditions include diabetes, cardiovascular diseases, respiratory diseases, birth complications, pregnancy, puberty.

Iodine deficiency is an important public health problem by affecting 10-15% of the population due to the diseases it causes. Iodine deficiency affects individuals of all ages. When the daily iodine requirement cannot be met, a group of mental, physical and developmental retardation symptoms called "Iodine deficiency disorders" (IEB) (Iodine deficiency disorders-IDD) occur. With the obligatory iodization of table salt, which started in 1998 in order to eliminate iodine deficiency in Turkey, this problem has been tried to be combated by switching to iodized salt consumption.

The study material was used by 73 adult individuals who applied to Atatürk University Faculty of Dentistry, Department of Periodontology for different reasons {1. group (H): periodontally healthy individuals, group 2 (P): individuals with periodontitis}. Urine samples will be collected from the participants without any periodontal intervention. Iodine levels in the urine will be studied.

There are studies in the literature to determine iodine deficiency and to determine the population periodontal disease status; however, there are no studies evaluating the possible relationship between iodine deficiency and periodontitis.

The aim of this study; To evaluate the iodine levels detected in the urine samples of patients with periodontitis by comparing them with healthy controls, and to investigate the possible role of iodine deficiency in the pathogenesis of periodontitis or a simple marker of disease activity in the light of these findings.

Study Type

Observational

Enrollment (Actual)

73

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Turkey
      • Erzurum, Turkey, 25240_
        • Ataturk University

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years to 65 years (ADULT, OLDER_ADULT)

Accepts Healthy Volunteers

Yes

Genders Eligible for Study

All

Sampling Method

Probability Sample

Study Population

individuals who referred to Atatürk University, Department of Periodontology

Description

Inclusion Criteria:

  • Individuals should not have any systemic disease that may or may not require medication, including salivary gland pathologies, and not particularly thyroid organ pathologies.
  • Individuals have not been continuously treated with anti-inflammatory, antioxidant or similar drugs in the last 6 months,
  • Individuals have not received periodontal treatment until 6 months ago,
  • Individuals must have at least 14 teeth
  • Patients diagnosed with stage 3 periodontitis

Exclusion Criteria:

  • Having a systemic disease such as cardiovascular, diabetes, hypertension, thyroid organ pathologies, chronic kidney failure
  • Being pregnant/breastfeeding
  • Being on medication for any reason
  • Being a smoker/tobacco user
  • Having another periodontal disease other than periodontitis
  • Having a chronic inflammatory disease (COPD, asthma)

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
Healthy
participants without periodontitis
Other: healthy
no intervention
periodontitis
participants with stage-3 periodontitis
Other: periodontitis
no intervention

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
iodine deficiency
Time Frame: 0-1 hours of the diagnosis
iodine level of participants
0-1 hours of the diagnosis

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Ataturk University

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (ACTUAL)

October 30, 2021

Primary Completion (ACTUAL)

October 30, 2022

Study Completion (ACTUAL)

November 30, 2022

Study Registration Dates

First Submitted

February 2, 2023

First Submitted That Met QC Criteria

February 2, 2023

First Posted (ACTUAL)

February 13, 2023

Study Record Updates

Last Update Posted (ACTUAL)

February 13, 2023

Last Update Submitted That Met QC Criteria

February 2, 2023

Last Verified

February 1, 2023

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 9375

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

UNDECIDED

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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