- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT05853991
Effects of Touch on Brain Connectivity and Metabolic Biomarkers in Preterm Infants
Effects of Affective Touch, Therapeutic Touch (OMT), and Static/Nonspecific Touch on Brain Connectivity and Metabolic Biomarkers in Preterm Infants
Improving the quality of life of preterm children by 2035 is the top priority of worldwide health organisations, including the WHO. Every year, 15 million preterm infants, particularly those under 32 weeks of age, are at significant risk of neurocognitive impairments with adverse health consequences (disability, developmental delay, disease), exacerbated by the lack of post-hospital care for newborns.
Intervening on the health of the preterm newborn through certain types of "touch" from its first days of life to activate its cutaneous senses permits, in reality, a significant improvement in the clinical state of the infant, hence promoting its growth, development, and social behaviour.
In the neonatal period, during which significant neurological development occurs, tactile interactions and close physical proximity between infants and caregivers have significant short-term effects on the health of premature infants (weight gain, brain and vision development) and medium- to long-term effects on their development and expression of sociability.
The likelihood that a premature newborn may develop attention and autism spectrum disorders, brain, gastrointestinal, and respiratory difficulties, as well as sleep disorders during the preschool years, is so high that clinical and social settings must prioritise care.
Utilizing functional magnetic resonance imaging (fRMI), computerized electroencephalogram (EEG), and metabolomics, the research aims to explore the effects of touch, including physiotherapy and manual therapy (OMT) approaches, on brain activity.
This research intends to examine the impact of touch on premature infants' brain activity (physical biomarker) and metabolic activity (biological biomarker).
Study Overview
Status
Conditions
Intervention / Treatment
Study Type
Enrollment (Anticipated)
Phase
- Not Applicable
Contacts and Locations
Study Contact
- Name: Francesco Cerritelli
- Phone Number: +393394332801
- Email: francesco.cerritelli@gmail.com
Study Contact Backup
- Name: Andrea Manzotti
- Phone Number: +393484044783
- Email: manzotti.andrea68@gmail.com
Study Locations
-
-
-
Milan, Italy
- Ospedale dei Bambini "Vittore Buzzi"
-
Contact:
- Gianluca Lista, PhD
- Phone Number: +390257995801
- Email: gianluca.lista@asst-fbf-sacco.it
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
- Child
Accepts Healthy Volunteers
Description
Inclusion Criteria:
- Preterm birth, between 32.0 and 33.6 weeks gestational age (GA);
- Absence of comorbidities that could affect the stability of vital parameters, and therefore represent a contraindication to the proposed intervention. Comorbities include sepsis, pathologies pertaining to surgery, respiratory or cardiovascular instability, birth from a drug-addicted or HIV-positive mother) or known congenital pathologies;
- Obtaining informed consent for participation in this research project from parents or legal guardians.
Exclusion Criteria:
- Preterm infants born before 32.0 weeks of GA and after 34 weeks and with respiratory and neurological pathologies and any additional comorbities.
- Children whose parents will not read and sign or in case of failure to obtain informed consent will be excluded from the study.
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Double
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: Therapeutic touch
The intervention will be based on 2 phases: 1) assessment to identify areas following the NAME procedure, 2) treatment to improve the function of the area identified
|
The intervention will be based on the specific assessment and treatment of the preterm developed by the team and validated through different studies.
|
Active Comparator: Affective touch
Participants will receive an affective touch intervention following the standardised procedure for affective touch
|
Application of affective touch
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Placebo Comparator: Static touch
Participants will receive a static touch intervention following the standardised procedure for static touch
|
Application of static touch
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
brain changes
Time Frame: 1 hour
|
pre-post changes in BOLD levels among different brain areas
|
1 hour
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
electroencephalogram (EEG) changes
Time Frame: 10 days
|
pre-post changes from baseline in the EEG power in slow delta waves band at the end of the treatment period
|
10 days
|
Proton Nuclear Magnetic Resonance Spectroscopy (1H NMR) at T1
Time Frame: 1 hour
|
pre-post changes in urinary metabolites as assessed by 1H NMR at T1
|
1 hour
|
Proton Nuclear Magnetic Resonance Spectroscopy (1H NMR) at T2
Time Frame: 4 days
|
pre-post changes in urinary metabolites as assessed by 1H NMR at T2
|
4 days
|
Proton Nuclear Magnetic Resonance Spectroscopy (1H NMR) at T3
Time Frame: 8 days
|
pre-post changes in urinary metabolites as assessed by 1H NMR at T3
|
8 days
|
Proton Nuclear Magnetic Resonance Spectroscopy (1H NMR) at T4
Time Frame: 12 days
|
pre-post changes in urinary metabolites as assessed by 1H NMR at T4
|
12 days
|
Proton Nuclear Magnetic Resonance Spectroscopy (1H NMR) at T5
Time Frame: 40 weeks
|
pre-post changes in urinary metabolites as assessed by 1H NMR at T5
|
40 weeks
|
Mass Spectrometry combined with Liquid Chromatography (CL-MS)at T1
Time Frame: 1 hour
|
pre-post changes in urinary metabolites as assessed by CL-MS at T1
|
1 hour
|
Mass Spectrometry combined with Liquid Chromatography (CL-MS)at T2
Time Frame: 4 days
|
pre-post changes in urinary metabolites as assessed by CL-MS at T2
|
4 days
|
Mass Spectrometry combined with Liquid Chromatography (CL-MS)at T3
Time Frame: 8 days
|
pre-post changes in urinary metabolites as assessed by CL-MS at T3
|
8 days
|
Mass Spectrometry combined with Liquid Chromatography (CL-MS)at T4
Time Frame: 12 days
|
pre-post changes in urinary metabolites as assessed by CL-MS at T4
|
12 days
|
Mass Spectrometry combined with Liquid Chromatography (CL-MS)at T5
Time Frame: 40 weeks
|
pre-post changes in urinary metabolites as assessed by CL-MS at T5
|
40 weeks
|
Mass Spectrometry combined with Gas Chromatography (CG-MS) at T1
Time Frame: 1 hour
|
pre-post changes in urinary metabolites as assessed by CG-MS at T1
|
1 hour
|
Mass Spectrometry combined with Gas Chromatography (CG-MS) at T2
Time Frame: 4 days
|
pre-post changes in urinary metabolites as assessed by CG-MS at T2
|
4 days
|
Mass Spectrometry combined with Gas Chromatography (CG-MS) at T3
Time Frame: 8 days
|
pre-post changes in urinary metabolites as assessed by CG-MS at T3
|
8 days
|
Mass Spectrometry combined with Gas Chromatography (CG-MS) at T4
Time Frame: 12 days
|
pre-post changes in urinary metabolites as assessed by CG-MS at T4
|
12 days
|
Mass Spectrometry combined with Gas Chromatography (CG-MS) at T5
Time Frame: 40 weeks
|
pre-post changes in urinary metabolites as assessed by CG-MS at T5
|
40 weeks
|
Collaborators and Investigators
Sponsor
Study record dates
Study Major Dates
Study Start (Anticipated)
Primary Completion (Anticipated)
Study Completion (Anticipated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- COME-23-01
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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