Zhejiang Nutrition and Health Study (NuLife)

Zhejiang Nutrition and Health Study: Nutrition and Lifespan Study (NuLife Study)

This project aims to explore the relationship between healthy lifespan and nutrition through a 10-year longitudinal study in Zhejiang Province. The cohort will include individuals in a wide range of age groups. The demographic, diet, lifestyle information, health status, and corresponding bio-samples will be collected carefully. It will give a deeper insight to the relation between nutrition and healthy aging and longevity. Ultimately, this research will contribute to evidence-based nutrition interventions to improve health outcomes and enhance quality of life.

Study Overview

• Status: Recruiting
• Conditions: Cardiovascular Diseases; Healthy Aging; Metabolic Disease

Detailed Description

This project aims to elucidate the relationship between healthy lifespan and nutrition through the establishment of a large-scale cohort of participants and longitudinal follow-ups spanning around 10 years in Zhejiang Province. The cohort will comprise individuals in a wide range of age groups starting at 6 years old. The participants will provide demographic information, anthropometry measurements, detailed diet, lifestyle data and health status, including 3-day dietary records and long-term food intake frequency recalls. Integrated with previous information, diverse bio-samples will also be collected to establish a multi-dimensional biobank. It will give a deeper insight to the relation between nutrition and healthy aging and longevity. Ultimately, this research will contribute to the development of evidence-based nutrition designed to improve health outcomes and enhance the quality of life for individuals of all ages.

• Study Type: Observational
• Enrollment (Estimated): 10000

Contacts and Locations

• Study Contact: Name: Ke Zhang, Bachelor; Phone Number: 86-18888641943; Email: zhangke@westlake.edu.cn
• Study Contact Backup: Name: Wanglong Gou, PhD; Phone Number: 86-13819107649; Email: gouwanglong@westlake.edu.cn

Study Locations

• China
  • Zhejiang
    • Hangzhou, Zhejiang, China, 310052
      • Recruiting
      • Zhejiang Provincial Center for Disease Control and Prevention
      • Contact: Danting Su, Master; Phone Number: 86-0571-87115262; Email: dtsu@cdc.zj.cn
      • Contact: Dan Han, Master; Phone Number: 86-0571-87115324; Email: dhan@cdc.zj.cn
      • Principal Investigator: Ronghua Zhang, Master
    • Hangzhou, Zhejiang, China
      • Recruiting
      • Westlake University
      • Contact: Ke Zhang, Bachelor; Phone Number: 86-18888641943; Email: zhangke@westlake.edu.cn
      • Principal Investigator: Ju-Sheng Zheng, PhD
      • Contact: Wanglong Gou, PhD; Phone Number: 86-13819107649; Email: gouwanglong@westlake.edu.cn

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Child; Adult; Older Adult
• Accepts Healthy Volunteers: Yes

• Sampling Method: Probability Sample

Study Population

Permanent residents in Zhejiang Province

Description

Inclusion Criteria:

• Chinese citizens who have resided in the surveyed area for at least 6 months before the survey within the last 12 months.
• Aged 6 years or older.
• They are included as resident households, which are comprised of people living together in one place based on family relationships, and at least one resident with permanent household registration.

Exclusion Criteria:

• Residents living in functional zones such as construction worker dormitories, military barracks, schools, nursing homes, etc.

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Occurrence of cardio-metabolic diseases	The investigators will track for occurrence of cardio-metabolic diseases by follow-up surveys collected by the Zhejiang Center for Disease Control and Prevention.	up to 10 years

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Changes in fasting blood glucose	Fasting glucose will be examined in mmol/L.	Every other year， up to 10 years
Changes in fasting blood HbA1c	Fasting blood HbA1c will be examined in %	Every other year， up to 10 years
Changes in fasting lipid metabolism	Triglyceride, cholesterol, high density lipoprotein cholesterol and low density lipoprotein cholesterol will be examined in mmol/L.	Every other year， up to 10 years
Changes in fasting blood highly sensitive C-reactive protein (CRP)	CRP will be examined in mg/L.	Every other year， up to 10 years
Changes in body mass index	Body mass index (BMI) will be calculated in kg/m^2	Every other year， up to 10 years
Changes in blood pressure	Blood pressure, including systolic and diastolic blood pressure, will be measured in mmHg	Every other year， up to 10 years
Changes in gut microbiome profiling	16S rRNA and/or shotgun metagenomic sequencing will be performed in stool samples.	Every other year， up to 10 years

Collaborators and Investigators

• Sponsor: Westlake University
• Collaborators: Zhejiang Provincial Center for Disease Control and Prevention
• Investigators: Principal Investigator: Ju-Sheng Zheng, PhD, Westlake University

Study record dates

Study Major Dates

• Study Start (Actual): July 19, 2023
• Primary Completion (Estimated): July 1, 2033
• Study Completion (Estimated): July 1, 2033

Study Registration Dates

• First Submitted: June 26, 2023
• First Submitted That Met QC Criteria: July 3, 2023
• First Posted (Actual): July 5, 2023

Study Record Updates

• Last Update Posted (Actual): August 29, 2023
• Last Update Submitted That Met QC Criteria: August 25, 2023
• Last Verified: August 1, 2023

More Information

Terms related to this study

• Keywords: Nutrition; Health; Healthy lifespan
• Additional Relevant MeSH Terms: Cardiovascular Diseases; Metabolic Diseases
• Other Study ID Numbers: 20230511JZS001

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No