Safety and Efficacy of NK510 to Treat Gastric Cancer

Exploratory Study of NK510 Cell Therapy Combined With Monoclonal Antibody in the Treatment of Recurrent and Refractory Advanced Gastric Cancer

This study will evaluate the safety and efficacy of NK510 in the treatment of relapsed and refractory advanced gastric cancer.NK510 will be administered in combination with PD-1 blockade or monoclonal anti-HER2 antibody. Patients are required to undergo a biopsy for confirmation of tumor PD-L1 and HER2 expression and. The safety and efficacy of this treatment will be evaluated.

Study Overview

• Status: Enrolling by invitation
• Conditions: Gastric Cancer
• Intervention / Treatment: Drug: NK510; Drug: Tislelizumab，atezolizumab or Trastuzumab

• Study Type: Interventional
• Enrollment (Estimated): 9
• Phase: Early Phase 1

Contacts and Locations

Study Locations

• China
  • Shanghai, China
    • Shanghai Tenth People's Hospital

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: No

Description

Inclusion Criteria:

• age≥18 years;
• Confirmed by histology or cytology: Adenocarcinoma at the gastric or gastroesophageal junction, with locally advanced unresectable or distant metastasis. Tumor tissue can be provided for central laboratory confirmation of HER2 and PD-L1 expression status;
• Received standard treatment before screening, currently in a state of progression or recurrence of the disease;
• According to RECIST v1.1 (Solid Tumor Efficacy Evaluation Criteria), there is at least one CT measurable lesion present;
• ECOG physical status score of 0-2;
• Expected survival >=3 months;
• Except for hair loss and fatigue, all previous anti-tumor treatments have alleviated toxicity to level 1 (CTCAE v5.0) or original baseline;
• Female of childbearing age must be non lactating and have a negative serum pregnancy test within 1 week prior to enrollment;
• Able to follow the research protocol and follow-up process;
• Voluntarily sign an informed consent form to participate in this study.

Exclusion Criteria：

• Individuals who have previously discontinued treatment with trastuzumab or PD-1 monoclonal antibody due to intolerance to drug toxicity reactions;
• Pregnant or lactating female patients;
• Patients with central nervous system metastasis (CNS) and/or cancerous meningitis and obvious symptoms;
• Having other malignant tumors that require active treatment within the past 3 years;
• Subjects with active, known or suspected autoimmune diseases [excluding type I diabetes, hypothyroidism requiring hormone replacement therapy only, skin diseases not requiring systemic treatment (such as vitiligo, psoriasis or alopecia) or diseases that are not expected to recur without external triggers;
• subjects have a history of immune deficiency, including HIV testing positive, or other acquired or congenital immune deficiency diseases or organ transplantation history;
• Have a history of serious cardiovascular and cerebrovascular diseases, including but not limited to: severe cardiac rhythm or conduction abnormalities, such as ventricular arrhythmias requiring clinical intervention, third degree atrioventricular block, etc; At rest, the QTc interval obtained from a 12 lead electrocardiogram examination is>480 ms; Acute coronary syndrome, congestive heart failure, aortic dissection,stroke, or other Grade 3 or above cardiovascular and cerebrovascular events occurred within 6 months prior to enrollment; The New York Heart Association (NYHA) has a heart function rating of ≥ II or a left ventricular ejection fraction (LVEF) of<50%; Clinically uncontrollable hypertension;
• Radical radiotherapy was performed within 4 weeks prior to enrollment;Local palliative radiotherapy or Chinese herbal medicine/traditional Chinese patent medicines and simple preparations with anti-tumor indications within 2 weeks before enrollment;
• Not fully recovered from major surgery or trauma within 2 weeks prior to enrollment;
• Participated in research drug trials and received research treatment or used research instruments within 4 weeks before enrollment;
• Other anti-tumor treatments outside of this research protocol are currently underway or planned;
• Received blood transfusion, erythropoietin, granulocyte colony stimulating factor (G-CSF), or granulocyte macrophage colony stimulating factor treatment within 2 weeks prior to enrollment;
• Subjects who received systemic treatment with corticosteroids (prednisone>10 mg/day or equivalent) or other immunosuppressive/enhancing drugs (such as thymosin, interleukin-2, and interferon) within 2 weeks prior to enrollment. Allowing selected subjects to inhale or topically use corticosteroids in the absence of active autoimmune diseases;

• The virological examination of hepatitis B or hepatitis C during screening meets any of the following criteria:

  1. HBsAg positive and peripheral blood HBV-DNA titer detection ≥ 1×10^3 copies/mL or upper limit of normal value;
  2. HCV antibody positive;

• Meet any of the following standards:

  1. Hematological:Neutrophil count <1.5×10^9/L; Platelet count <75×10^9/L; Hemoglobin < 9 g/dL;
  2. Hepatic:ALT>3×ULN (tumor liver metastasis ≥ 5×ULN); AST>3×ULN (tumor liver metastasis ≥ 5×ULN); TBIL>1.5×ULN or TBIL>2.5(3.0 mg/dL) in Gilbert syndrome subjects;
  3. Renal:Serum creatinine>1.5×ULN or creatinine clearance<50mL/min;
• Any uncertain factors that affect the safety or compliance of patients;
• Researchers believe that any other serious or uncontrollable medical disease, active infection,abnormal physical examination, laboratory examination, mental state change, or mental illness increases the risk of the subject or affects the research results.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: Non-Randomized
• Interventional Model: Sequential Assignment
• Masking: None (Open Label)

Number of Arms

3

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Group A (low-dose NK510 monotherapy); NK510 9×10^9 NK cells/dose.	Drug: NK510; NK510 will be administered through intravenous infusion.3 infusions on Day 0，Day 2 and day 3 for a cycle，for a total of two cycles.
Experimental: Group B (low-dose NK510 combined mAbs); NK510 9×10^9 NK cells/dose. PD-1 blockade or anti-HER2 mAbs.	Drug: NK510; NK510 will be administered through intravenous infusion.3 infusions on Day 0，Day 2 and day 3 for a cycle，for a total of two cycles.; Drug: Tislelizumab，atezolizumab or Trastuzumab; Administer according to the instructions.
Experimental: Group C (high-dose NK510 combined mAbs); NK510 12×10^9 NK cells/dose. PD-1 blockade or anti-HER2 mAbs.	Drug: NK510; NK510 will be administered through intravenous infusion.3 infusions on Day 0，Day 2 and day 3 for a cycle，for a total of two cycles.; Drug: Tislelizumab，atezolizumab or Trastuzumab; Administer according to the instructions.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Dose-Limiting Toxicity	To evaluate the DLT during N510 treatment	6 weeks
Maximal Tolerable Dose	To evaluate the MTD of NK510	6 weeks

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Overall response rate (ORR)	Effectiveness Metrics	6 weeks

Collaborators and Investigators

• Sponsor: Base Therapeutics (Shanghai) Co., Ltd.
• Collaborators: Shanghai 10th People's Hospital

Study record dates

Study Major Dates

• Study Start (Estimated): November 1, 2023
• Primary Completion (Estimated): November 1, 2024
• Study Completion (Estimated): November 1, 2024

Study Registration Dates

• First Submitted: October 17, 2023
• First Submitted That Met QC Criteria: October 22, 2023
• First Posted (Actual): October 25, 2023

Study Record Updates

• Last Update Posted (Actual): October 25, 2023
• Last Update Submitted That Met QC Criteria: October 22, 2023
• Last Verified: October 1, 2023

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Digestive System Diseases; Neoplasms; Neoplasms by Site; Gastrointestinal Neoplasms; Digestive System Neoplasms; Gastrointestinal Diseases; Stomach Diseases; Stomach Neoplasms; Molecular Mechanisms of Pharmacological Action; Antineoplastic Agents; Antineoplastic Agents, Immunological; Immune Checkpoint Inhibitors; Trastuzumab; Atezolizumab; Tislelizumab
• Other Study ID Numbers: NK510-08

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No