Healthcare Utilization in Liver Cirrhosis Patients, a Multicenter Retrospective Cohort Study

Multicenter, retrospective cohort study investigating healthcare utilization in compensated and decompensated liver cirrhosis patients, including disease course and characteristics associated with healthcare utilization and, for example psychosocial factors.

Study Overview

• Status: Recruiting
• Conditions: Liver Cirrhosis
• Intervention / Treatment: Other: No intervention

• Study Type: Observational
• Enrollment (Estimated): 600

Contacts and Locations

• Study Contact: Name: B. van Ruijven, MD; Phone Number: +31631239360; Email: britt.vanruijven@maastrichtuniversity.nl

Study Locations

• Netherlands
  • Gelderland
    • Apeldoorn, Gelderland, Netherlands, 7334 DZ
      • Recruiting
      • Gelre Ziekenhuizen
      • Contact: G. Veldhuijzen, MD, PhD; Phone Number: +31(0)55844 6878; Email: g.veldhuijzen@gelre.nl
  • Limburg
    • Maastricht, Limburg, Netherlands, 6202 AZ
      • Recruiting
      • Maastricht University Medical Center
      • Contact: T.J.G. Gevers, MD, PhD; Phone Number: +31(0)43-3875021; Email: tom.gevers@mumc.nl

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: No

• Sampling Method: Non-Probability Sample

Study Population

Patients with liver cirrhosis

Description

Inclusion Criteria:

• Patients ≥ 18 years of age
• Liver cirrhosis, based on biopsy, fibroscan or diagnostic imaging data

Exclusion Criteria:

• Known malignancy with hepatic metastasis at baseline
• Liver transplantation at baseline

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
Number of liver cirrhosis related outpatient contacts before liver cirrhosis complications	2 years before complication, death or loss to follow-up
Number of liver cirrhosis related radiographic imaging before liver cirrhosis complications	2 years before complication, death or loss to follow-up
Number of liver cirrhosis related esophagogastroscopies before liver cirrhosis complications	2 years before complication, death or loss to follow-up
Number of liver cirrhosis related elastographies before liver cirrhosis complications	2 years before complication, death or loss to follow-up

Collaborators and Investigators

• Sponsor: Maastricht University Medical Center
• Collaborators: Gelre Hospitals

Study record dates

Study Major Dates

• Study Start (Actual): September 1, 2022
• Primary Completion (Estimated): December 31, 2026
• Study Completion (Estimated): December 31, 2027

Study Registration Dates

• First Submitted: May 23, 2023
• First Submitted That Met QC Criteria: November 20, 2023
• First Posted (Actual): November 29, 2023

Study Record Updates

• Last Update Posted (Estimated): September 26, 2025
• Last Update Submitted That Met QC Criteria: September 25, 2025
• Last Verified: December 1, 2024

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Pathologic Processes; Digestive System Diseases; Liver Diseases; Fibrosis; Pathological Conditions, Signs and Symptoms; Liver Cirrhosis
• Other Study ID Numbers: 2021-2857-A-2

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: UNDECIDED

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No