Measuring Electrical Properties of Breast Tissues
Intervention / Treatment
A new approach to imaging that uses low-power microwaves to scan the breast has been developed. Since the imaging system uses low power, there is no risk of tissue heating. The imaging system places the sensors in contact with the breast and does not require compression. The research team at the University of Calgary has previously developed microwave imaging systems that have been tested on volunteers and patients. This included repeated scanning of a group of volunteers to evaluate the consistency of the approach. The information collected from experiences scanning volunteers and patients have been reviewed and translated into a next-generation imaging system design. Aspects of this system have been further improved by Wave View Imaging, which is a company formed by members of the University's research team.
The proposed study involves collecting electrical property measurements of breast tissues and comparing these measurements to clinical information. The investigators also aim to compare regions of interest in the microwave scans with regions of interest in the mammograms. This includes regions dominated by fibroglandular tissues, as well as regions of interest that correspond to anomalies identified in the mammograms
The plan is to scan both breasts of up to 200 volunteers. Each volunteer will participate in a single scanning session. Breast tissue composition (VOLPARA score) will be compared with the microwave properties and registration of mammograms with microwave images will be performed for a more detailed comparison.
- Not Applicable
Contacts and Locations
- Name: Anita Garland
- Phone Number: 4037031664
- Email: firstname.lastname@example.org
Ages Eligible for Study
- Older Adult
Accepts Healthy Volunteers
- Must have had a previous mammogram in the last 2 years
- Participants currently undergoing chemotherapy and/or radiation treatment.
- Participants with breast implants.
- Participants who are breast or breastfeeding.
- Participants with active breast infections.
- Participants with nipple piercings (unless they can be removed prior to scanning).
- Participants with an implanted electronic device.
- Participants with physical limitations that prevent them from placing their breasts in the scanner.
How is the study designed?
- Primary Purpose: Other
- Allocation: N/A
- Interventional Model: Single Group Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm
Intervention / Treatment
What is the study measuring?
Primary Outcome Measures
Measurement of electrical properties of breast tissue
Time Frame: 18 months
The electrical properties will be estimated for each volunteer and an image that maps these properties will be created.
Secondary Outcome Measures
Correlation between the electrical properties of breast tissue and breast density
Time Frame: 18 months
Comparison of the microwave images and mammograms in 2 ways: VOLPARA scores versus average electrical properties and comparison of regions of interest in both images
Collaborators and Investigators
Publications and helpful links
- Smith, K., et al. "Microwave Imaging of the Breast: Consistency of Measurements Over Time." IEEE Journal of Electromagnetics, RF and Microwaves in Medicine and Biology, vol. 6, no. 1, 2022, pp. 61-67, https://doi.org/10.1109/JERM.2021.3099014.
- Smith K, Bourqui J, Wang Z, Besler B, Lesiuk M, Roumeliotis M, Quirk S, Grendarova P, Pinilla J, Price S, Docktor B, Fear E. Microwave imaging for monitoring breast cancer treatment: A pilot study. Med Phys. 2023 Nov;50(11):7118-7129. doi: 10.1002/mp.16756. Epub 2023 Oct 6.
Study record dates
Study Major Dates
Study Start (Estimated)
Primary Completion (Estimated)
Study Completion (Estimated)
Study Registration Dates
First Submitted That Met QC Criteria
First Posted (Estimated)
Study Record Updates
Last Update Posted (Estimated)
Last Update Submitted That Met QC Criteria
Terms related to this study
Other Study ID Numbers
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
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