- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT06171711
Exposure Therapy Study In Adults With Eating Disorders
Exposure Therapy for Anorexia Nervosa Pilot Trial
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
The current proposal will evaluate the feasibility, acceptability, and preliminary efficacy of Exposure Therapy for anorexia nervosa (AN) Spectrum Disorders (Exp-AN), an innovative treatment rooted in principles of inhibitory learning. Exp-AN will target anxiety about both eating and weight gain by combining in vivo (i.e., in real life) and imaginal (i.e., mental) exposure in novel ways (e.g., eating a feared food while listening to a recording describing fears about weight gain).
The central hypothesis is that Exp-AN will effectively target anxiety related to eating and weight gain via inhibitory learning, and improve treatment outcomes. The investigator will test two aims:
Aim 1. Evaluate the feasibility, acceptability, and preliminary efficacy of Exp-AN.
Hypothesis 1.1: Exp-AN will be feasible, with satisfactory levels of recruitment (≥50%) and retention (≥70%).
Hypothesis 1.2: Participants will engage in Exp-AN, as measured by completion of the five treatment modules (≥80%) and therapy homework (≥60%).
Hypothesis 1.3: Participants will rate all five Exp-AN modules as acceptable.
Hypothesis 1.4: Exp-AN will result in increases in BMI and decreases in AN symptomatology.
Aim 2. Investigate Exp-AN's mechanisms of action, and if mechanisms are associated with positive outcomes.
Hypothesis 2.1: Exp-AN will result in decreases in anxiety between sessions, decreases in anxious beliefs, and increases in anxiety tolerance.
Hypothesis 2.2: Changes in anxiety ratings, anxious beliefs, and tolerance of anxiety will be associated with weight gain and reduced AN symptomatology.
Study Type
Enrollment (Estimated)
Phase
- Not Applicable
Contacts and Locations
Study Contact
- Name: Jamal Essayli, Ph.D
- Phone Number: 7175310003
- Email: jessayli@pennstatehealth.psu.edu
Study Locations
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Pennsylvania
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Hershey, Pennsylvania, United States, 17033
- 905 W Govener Rd
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
- Adult
- Older Adult
Accepts Healthy Volunteers
Description
Inclusion Criteria:
Participants will be English speakers, ages 18 - 65 years, of all genders, with AN-spectrum disorders, defined as a diagnosis of AN, atypical AN, or AN in partial remission.
- Participants with AN, atypical AN, and AN in partial remission share the same DSM-5 criteria, with the exception of criterion A: "Significantly low body weight."
- Individuals with atypical AN are weight suppressed, but not "objectively" underweight (e.g., someone who experiences rapid weight loss from a BMI of 27 to 21). Those with AN in partial remission are partially or fully weight restored (e.g., after stepping down from an inpatient setting), but continue to experience significant AN behaviors (e.g., food avoidance) and/or cognitions (e.g., fear of weight gain).
- Diagnoses will be determined using the Structured Clinical Interview for DSM-5 - Research Version (SCID-5-RV).93 All participants in this study will be monitored by a Penn State Health medical provider.
- All individuals who are deemed to be, or become, unsafe by their supervising medical provider will be admitted to our hospital or another facility for medical stabilization.
Exclusion Criteria:
- Participants will be excluded if they are below 18 years of age.
- Those identified as non-English speakers will be excluded due to lack of funding to translate the measures to other languages.
- Individuals with other EDs (e.g., bulimia nervosa) will be excluded.
Participants will be excluded if they are:
a.at high risk for suicide i.Suicide risk will be determined using the Columbia Suicide Severity Rating Scale (CSSRS) screen. The CSSRS will be administered by the study coordinator when they initially meet with the participant for Session 0 (see section 7 of this protocol), and at the start of every weekly session with the study therapist. The study coordinator and study therapists will be trained by the PI to adhere to a Suicide Assessment Protocol. This protocol will state that all participants who report high suicide risk should be sent by an ambulance to our institution's emergency department.
b.pregnant determined by verbal verification (the study coordinator will ask participants if they are pregnant when completing the eligibility checklist and/or during the informed consent process).
c. Meet DSM-5 criteria for a psychotic disorder and/or have an intellectual disability.
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: N/A
- Interventional Model: Single Group Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: Exposure Therapy
Exp-AN will effectively target anxiety related to eating and weight gain via inhibitory learning, and improve treatment outcomes.
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The proposed study will explore whether Exp-AN works via inhibitory learning (i.e., decreasing anxious beliefs and increasing anxiety tolerance) and/or between-session habituation (i.e., decreasing anxiety levels across therapy sessions), and the importance of targeting anxiety about eating versus weight gain.
Results will provide information about the degree to which all three mechanisms of action (i.e., changes in anxiety ratings, anxious beliefs, and tolerance of anxiety) predict improved AN symptomatology across both treatments.
Research that discovers whether specific treatments (e.g., Exp-AN) work in the way the investigators think they do (e.g., by increasing tolerance of anxiety), and whether modifying intervention targets (e.g., tolerance of anxiety) helps people get better (e.g., reduced AN symptomatology), will ultimately lead to more personalized, mechanism-based, and effective treatments (Insel 2014; Insel et al., 2010).
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Structured Clinical Interview for DSM-5-Research Version (SCID-5-RV)
Time Frame: Admission-Baseline (Week 0)
|
The Structured Clinical Interview for DSM-5-Research Version (SCID-5-RV) is comprehensive, including most disorders, subtypes severity, and course specifiers.
The instrument provides a diagnostic process to covers the DSM-5 diagnoses most commonly seen in clinical setting such as depressive and bipolar disorders; schizophrenia spectrum and other psychotic disorders; substance use disorders; anxiety disorders (panic disorder, agoraphobia, social anxiety disorder, generalized anxiety disorder); obsessive-compulsive disorder; posttraumatic stress disorder; attention-deficit/hyperactivity disorder, eating disorders and adjustment disorder.
It also screens for 17 additional DSM-5 disorders.
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Admission-Baseline (Week 0)
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Demographic Form
Time Frame: Admission-Baseline (Week 0)
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The Demographic Form is a 10-item self-report questionnaire.
It was designed to assess information about the participant's age, race/ethnicity, past medical history, and eating disorder history.
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Admission-Baseline (Week 0)
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Food Phobia Survey
Time Frame: Admission-Baseline (Week 0)
|
The Food Phobia Survey is a 360-item self-report questionnaire.
It was designed to assess participant's frequency, fear, guilt, appeal to food, and behaviors associated with a diagnosis of an eating disorder.
The scores of items are calculated and range from 0 to 5. The higher rating indicates a higher frequency, fear, guilt, and appeal to food.
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Admission-Baseline (Week 0)
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Eating Disorder Examination - Self-Report Questionnaire (EDE-Q)
Time Frame: Admission-Baseline (Week 0)
|
The Eating Disorder Examination Questionnaire (EDE-Q) is a 28-item self-report questionnaire.
It was designed to assess the range, frequency, and severity of behaviors associated with a diagnosis of an eating disorder.
A total score is obtained by summing the four subscales scores and dividing the total by the number of subscales.
The score of items are calculated and range from 0 to 36.
The higher score indicate greater ED symptoms.
|
Admission-Baseline (Week 0)
|
Fear of Food Measure (FOFM)
Time Frame: Admission-Baseline (Week 0)
|
The Fear of Food Measure (FORM) is a 23-item self-report questionnaire.
It examines the participant's severity of behaviors associated with a diagnosis of an eating disorder.
Each item is scored on a 1-7 scale.
The questionnaire range from 23 to 161 meaning 23: no fear of food and 161 meaning severe fear of food.
|
Admission-Baseline (Week 0)
|
Body Shape Questionnaire (BSQ)
Time Frame: Admission-Baseline (Week 0)
|
The BSQ is a self-reported measurement of the body shape concerns typical of bulimia nervosa and anorexia nervosa.
The questionnaire has 34 items scored from 0 to 6 points (least and most impaired, respectively), with the sum of the questions giving a range from 0 to 204.
The higher score indicates greater concerns about body shape.
|
Admission-Baseline (Week 0)
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Clinical Impairment Assessment (CIA)
Time Frame: Admission-Baseline (Week 0)
|
The Clinical Impairment Assessment Questionnaire (CIA) is a 16-item self-report measure of the severity of psychosocial impairment due to eating disorder features and focuses on the past 28 days.
The 16 items cover impairment in domains of life that are typically affected by eating disorder psychopathology: mood and self-perception, cognitive functioning, interpersonal functioning, and work performance.
The responses are scored 0,1,2 and 3, with a higher rating indicating a higher level of impairment.
The total range is between 0 and 48.
|
Admission-Baseline (Week 0)
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Eating Disorder Fear Questionnaire (EDFQ)
Time Frame: Admission-Baseline (Week 0)
|
The Eating Disorder Fear Questionnaire (EDFQ) is a 20-item self-report questionnaire.
It examines the participant's severity of behaviors associated with a diagnosis of an eating disorder.
The response range between 1 to 7 with a total range of 20 to 140.
The higher rating indicates a higher severe impairment.
|
Admission-Baseline (Week 0)
|
Treatment Acceptability Questionnaire
Time Frame: Admission-Baseline (Week 0)
|
The Treatment Acceptability Questionnaire is a 10-item self-report questionnaire.
It examines the participants' perspective on the modules in the exposure therapy.
The response range between 1 to 7, with a total range of 10 to 70.
The higher rating indicates a higher rating of treatment acceptability.
|
Admission-Baseline (Week 0)
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Eating Disorder Examination - Self-Report Questionnaire (EDE-Q)
Time Frame: Session 5 (Week 5)
|
The Eating Disorder Examination Questionnaire (EDE-Q) is a 28-item self-report questionnaire.
It was designed to assess the range, frequency, and severity of behaviors associated with a diagnosis of an eating disorder.
A total score is obtained by summing the four subscales scores and dividing the total by the number of subscales.
The score of items are calculated and range from 0 to 36.
The higher score indicate greater ED symptoms.
|
Session 5 (Week 5)
|
Fear of Food Measure (FOFM)
Time Frame: Session 5 (Week 5)
|
The Fear of Food Measure (FORM) is a 23-item self-report questionnaire.
It examines the participant's severity of behaviors associated with a diagnosis of an eating disorder.
Each item is scored on a 1-7 scale.
The questionnaire range from 23 to 161 meaning 23: no fear of food and 161 meaning severe fear of food.
|
Session 5 (Week 5)
|
Body Shape Questionnaire (BSQ)
Time Frame: Session 5 (Week 5)
|
The BSQ is a self-reported measurement of the body shape concerns typical of bulimia nervosa and anorexia nervosa.
The questionnaire has 34 items scored from 0 to 6 points (least and most impaired, respectively), with the sum of the questions giving a range from 0 to 204.The higher score indicates greater concerns about body shape.
|
Session 5 (Week 5)
|
Clinical Impairment Assessment (CIA)
Time Frame: Session 5 (Week 5)
|
The Clinical Impairment Assessment Questionnaire (CIA) is a 16-item self-report measure of the severity of psychosocial impairment due to eating disorder features and focuses on the past 28 days.
The 16 items cover impairment in domains of life that are typically affected by eating disorder psychopathology: mood and self-perception, cognitive functioning, interpersonal functioning, and work performance.
The responses are scored 0,1,2 and 3, with a higher rating indicating a higher level of impairment.
The total range is between 0 and 48.
|
Session 5 (Week 5)
|
Eating Disorder Fear Questionnaire (EDFQ)
Time Frame: Session 5 (Week 5)
|
The Eating Disorder Fear Questionnaire (EDFQ) is a 20-item self-report questionnaire.
It examines the participant's severity of behaviors associated with a diagnosis of an eating disorder.
The response range between 1 to 7 with a total range of 20 to 140.
The higher rating indicates a higher severe impairment.
|
Session 5 (Week 5)
|
Treatment Acceptability Questionnaire
Time Frame: Session 5 (Week 5)
|
The Treatment Acceptability Questionnaire is a 10-item self-report questionnaire.
It examines the participants' perspective on the modules in the exposure therapy.
The response range between 1 to 7, with a total range of 10 to 70.
The higher rating indicates a higher rating of treatment acceptability.
|
Session 5 (Week 5)
|
Eating Disorder Examination - Self-Report Questionnaire (EDE-Q)
Time Frame: Session 10 (Week 10)
|
The Eating Disorder Examination Questionnaire (EDE-Q) is a 28-item self-report questionnaire.
It was designed to assess the range, frequency, and severity of behaviors associated with a diagnosis of an eating disorder.
A total score is obtained by summing the four subscales scores and dividing the total by the number of subscales.
The score of items are calculated and range from 0 to 36.
The higher score indicate greater ED symptoms.
|
Session 10 (Week 10)
|
Fear of Food Measure (FOFM)
Time Frame: Session 10 (Week 10)
|
The Fear of Food Measure (FORM) is a 23-item self-report questionnaire.
It examines the participant's severity of behaviors associated with a diagnosis of an eating disorder.
Each item is scored on a 1-7 scale.
The questionnaire range from 23 to 161 meaning 23: no fear of food and 161 meaning severe fear of food.
|
Session 10 (Week 10)
|
Body Shape Questionnaire (BSQ)
Time Frame: Session 10 (Week 10)
|
The BSQ is a self-reported measurement of the body shape concerns typical of bulimia nervosa and anorexia nervosa.
The questionnaire has 34 items scored from 0 to 6 points (least and most impaired, respectively), with the sum of the questions giving a range from 0 to 204.The higher score indicates greater concerns about body shape.
|
Session 10 (Week 10)
|
Clinical Impairment Assessment (CIA)
Time Frame: Session 10 (Week 10)
|
The Clinical Impairment Assessment Questionnaire (CIA) is a 16-item self-report measure of the severity of psychosocial impairment due to eating disorder features and focuses on the past 28 days.
The 16 items cover impairment in domains of life that are typically affected by eating disorder psychopathology: mood and self-perception, cognitive functioning, interpersonal functioning, and work performance.
The responses are scored 0,1,2 and 3, with a higher rating indicating a higher level of impairment.
The total range is between 0 and 48.
|
Session 10 (Week 10)
|
Eating Disorder Fear Questionnaire (EDFQ)
Time Frame: Session 10 (Week 10)
|
The Eating Disorder Fear Questionnaire (EDFQ) is a 20-item self-report questionnaire.
It examines the participant's severity of behaviors associated with a diagnosis of an eating disorder.
The response range between 1 to 7 with a total range of 20 to 140.
The higher rating indicates a higher severe impairment.
|
Session 10 (Week 10)
|
Treatment Acceptability Questionnaire
Time Frame: Session 10 (Week 10)
|
The Treatment Acceptability Questionnaire is a 10-item self-report questionnaire.
It examines the participants' perspective on the modules in the exposure therapy.
The response range between 1 to 7, with a total range of 10 to 70.
The higher rating indicates a higher rating of treatment acceptability.
|
Session 10 (Week 10)
|
Eating Disorder Examination - Self-Report Questionnaire (EDE-Q)
Time Frame: Session 15 (Week 15)
|
The Eating Disorder Examination Questionnaire (EDE-Q) is a 28-item self-report questionnaire.
It was designed to assess the range, frequency, and severity of behaviors associated with a diagnosis of an eating disorder.
A total score is obtained by summing the four subscales scores and dividing the total by the number of subscales.
The score of items are calculated and range from 0 to 36.
The higher score indicate greater ED symptoms.
|
Session 15 (Week 15)
|
Fear of Food Measure (FOFM)
Time Frame: Session 15 (Week 15)
|
The Fear of Food Measure (FORM) is a 23-item self-report questionnaire.
It examines the participant's severity of behaviors associated with a diagnosis of an eating disorder.
Each item is scored on a 1-7 scale.
The questionnaire range from 23 to 161 meaning 23: no fear of food and 161 meaning severe fear of food.
|
Session 15 (Week 15)
|
Body Shape Questionnaire (BSQ)
Time Frame: Session 15 (Week 15)
|
The BSQ is a self-reported measurement of the body shape concerns typical of bulimia nervosa and anorexia nervosa.
The questionnaire has 34 items scored from 0 to 6 points (least and most impaired, respectively), with the sum of the questions giving a range from 0 to 204.The higher score indicates greater concerns about body shape.
|
Session 15 (Week 15)
|
Clinical Impairment Assessment (CIA)
Time Frame: Session 15 (Week 15)
|
The Clinical Impairment Assessment Questionnaire (CIA) is a 16-item self-report measure of the severity of psychosocial impairment due to eating disorder features and focuses on the past 28 days.
The 16 items cover impairment in domains of life that are typically affected by eating disorder psychopathology: mood and self-perception, cognitive functioning, interpersonal functioning, and work performance.
The responses are scored 0,1,2 and 3, with a higher rating indicating a higher level of impairment.
The total range is between 0 and 48.
|
Session 15 (Week 15)
|
Eating Disorder Fear Questionnaire (EDFQ)
Time Frame: Session 15 (Week 15)
|
The Eating Disorder Fear Questionnaire (EDFQ) is a 20-item self-report questionnaire.
It examines the participant's severity of behaviors associated with a diagnosis of an eating disorder.
The response range between 1 to 7 with a total range of 20 to 140.
The higher rating indicates a higher severe impairment.
|
Session 15 (Week 15)
|
Treatment Acceptability Questionnaire
Time Frame: Session 15 (Week 15)
|
The Treatment Acceptability Questionnaire is a 10-item self-report questionnaire.
It examines the participants' perspective on the modules in the exposure therapy.
The response range between 1 to 7, with a total range of 10 to 70.
The higher rating indicates a higher rating of treatment acceptability.
|
Session 15 (Week 15)
|
Eating Disorder Examination - Self-Report Questionnaire (EDE-Q)
Time Frame: Discharge_Session 20 (Week 20)
|
The Eating Disorder Examination Questionnaire (EDE-Q) is a 28-item self-report questionnaire.
It was designed to assess the range, frequency, and severity of behaviors associated with a diagnosis of an eating disorder.
A total score is obtained by summing the four subscales scores and dividing the total by the number of subscales.
The score of items are calculated and range from 0 to 36.
The higher score indicate greater ED symptoms.
|
Discharge_Session 20 (Week 20)
|
Fear of Food Measure (FOFM)
Time Frame: Discharge_Session 20 (Week 20)
|
The Fear of Food Measure (FORM) is a 23-item self-report questionnaire.
It examines the participant's severity of behaviors associated with a diagnosis of an eating disorder.
Each item is scored on a 1-7 scale.
The questionnaire range from 23 to 161 meaning 23: no fear of food and 161 meaning severe fear of food.
|
Discharge_Session 20 (Week 20)
|
Body Shape Questionnaire (BSQ)
Time Frame: Discharge_Session 20 (Week 20)
|
The BSQ is a self-reported measurement of the body shape concerns typical of bulimia nervosa and anorexia nervosa.
The questionnaire has 34 items scored from 0 to 6 points (least and most impaired, respectively), with the sum of the questions giving a range from 0 to 204.The higher score indicates greater concerns about body shape .
|
Discharge_Session 20 (Week 20)
|
Clinical Impairment Assessment (CIA)
Time Frame: Discharge_Session 20 (Week 20)
|
The Clinical Impairment Assessment Questionnaire (CIA) is a 16-item self-report measure of the severity of psychosocial impairment due to eating disorder features and focuses on the past 28 days.
The 16 items cover impairment in domains of life that are typically affected by eating disorder psychopathology: mood and self-perception, cognitive functioning, interpersonal functioning, and work performance.
The responses are scored 0,1,2 and 3, with a higher rating indicating a higher level of impairment.
The total range is between 0 and 48.
|
Discharge_Session 20 (Week 20)
|
Eating Disorder Fear Questionnaire (EDFQ)
Time Frame: Discharge_Session 20 (Week 20)
|
The Eating Disorder Fear Questionnaire (EDFQ) is a 20-item self-report questionnaire.
It examines the participant's severity of behaviors associated with a diagnosis of an eating disorder.
The response range between 1 to 7 with a total range of 20 to 140.
The higher rating indicates a higher severe impairment.
|
Discharge_Session 20 (Week 20)
|
Treatment Acceptability Questionnaire
Time Frame: Discharge_Session 20 (Week 20)
|
he Treatment Acceptability Questionnaire is a 10-item self-report questionnaire.
It examines the participants' perspective on the modules in the exposure therapy.
The response range between 1 to 7, with a total range of 10 to 70.
The higher rating indicates a higher rating of treatment acceptability.
|
Discharge_Session 20 (Week 20)
|
Collaborators and Investigators
Sponsor
Investigators
- Principal Investigator: Jamal Essayli, Penn State University
Study record dates
Study Major Dates
Study Start (Estimated)
Primary Completion (Estimated)
Study Completion (Estimated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 23573
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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