Chinese Occupational Population Cohort of Lifestyle and Physical Fitness (LiFitChina) (LiFitChina)

Effects of Lifestyle and Physical Fitness on Cardiovascular Health: a Cohort Study in Chinese Occupational Population

The incidence and prevalence of metabolic risk factors such as obesity, hypertension, diabetes, and dyslipidemia, as well as cardiovascular diseases (CVD), are continuously rising among the occupational population in China, primarily comprising the middle-aged and young adults. Unhealthy lifestyles and declining physical fitness are independent risk factors affecting cardiovascular health. Additionally, the level of physical fitness is influenced by postnatal lifestyles. Lifestyle factors related to cardiovascular health in the occupational population encompass various aspects, including smoking, physical activity, diet, sleep, psychological stress, etc. These factors may interact or have a synergistic effect, necessitating a comprehensive assessment.

This project proposes a prospective cohort study design to establish a monitoring cohort for lifestyle and physical fitness among the occupational population. The study will track and follow individuals with or without any CVD metabolic risk factors, collecting information on general status, lifestyle, physical fitness, and health examination data. Exposure factors such as lifestyle and physical fitness will be measured annually, and the occurrence of CVD-related health outcomes will be observed. The aim is to develop a comprehensive evaluation index for cardiovascular health lifestyle, analyze the direct and indirect impacts of lifestyle and physical fitness on the occurrence and development of CVD, and explore potential mediating and moderating effects of physical fitness in the association between lifestyle and cardiovascular health.

Study Overview

• Status: Recruiting
• Conditions: Cardiovascular Diseases; Lifestyle; Physical Fitness

• Study Type: Observational
• Enrollment (Estimated): 18512

Contacts and Locations

• Study Contact: Name: Hongyi Du, MD PhD; Phone Number: 86-10-88396087; Email: duhy@bjmu.edu.cn

Study Locations

• China
  • Beijing
    • Beijing, Beijing, China
      • Recruiting
      • Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College
      • Contact: Xue Feng, MD PhD; Phone Number: +86-15601378512; Email: 29611290@qq.com

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult
• Accepts Healthy Volunteers: Yes

• Sampling Method: Non-Probability Sample

Study Population

occupational person free of cardiovascular disease at baseline in China

Description

Inclusion Criteria:

• adults between 18-59 years of age
• occupational staff
• willing to accept long-term follow-up

Exclusion Criteria:

• participants with previous CVD history such as myocardial infarction, stroke and severe aortic stenosis;
• with cancer;
• with congenital genetic diseases, or cannot cooperate with the investigation and follow-up due to acquired diseases, such as congenital heart disease, paralysis, deafness, dementia, mental abnormality, developmental retardation, etc.;
• with exercise contraindications;
• duration of pregnancy;
• refuse to sign the informed consent.

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
the composite end point of new major adverse cardiovascular events	including cardiovascular death, nonfatal myocardial infarction, nonfatal stroke, coronary revascularization and unstable angina pectoris requiring hospitalization	10 years

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
new incidence of each major adverse cardiovascular events	new incidence of cardiovascular death, nonfatal myocardial infarction, nonfatal stroke, coronary revascularization, unstable angina requiring hospitalization and other major adverse cardiovascular events	10 years
new incidence of cancer	new incidence of cancer and all-cause death	10 years
new incidence of all-cause death	new incidence of all-cause death	10 years
level of systolic pressure	The level of systolic pressure measured at each follow-up evaluation time point	10 years
level of diastolic pressure	The level of diastolic pressure measured at each follow-up evaluation time point	10 years
level of blood lipid	The level of blood lipid measured at each follow-up evaluation time point	10 years
level of BMI	The level of BMI (weight and height will be combined to report BMI in kg/m^2) measured at each follow-up evaluation time point	10 years
level of maximal oxygen uptake (VO2max)	The level of VO2max which is obtained by submaximal exercise testing on cycle ergometer with two-stage workload to assess cardiorespiratory fitness measured at each follow-up evaluation time point	10 years
level of metabolic equivalents (METs)	The level of METs which is obtained by submaximal exercise testing on cycle ergometer with two-stage workload to assess cardiorespiratory fitness measured at each follow-up evaluation time point	10 years

Collaborators and Investigators

• Sponsor: China National Center for Cardiovascular Diseases

Study record dates

Study Major Dates

• Study Start (Actual): December 11, 2023
• Primary Completion (Estimated): December 11, 2026
• Study Completion (Estimated): December 11, 2026

Study Registration Dates

• First Submitted: February 17, 2024
• First Submitted That Met QC Criteria: February 17, 2024
• First Posted (Actual): February 23, 2024

Study Record Updates

• Last Update Posted (Actual): February 28, 2024
• Last Update Submitted That Met QC Criteria: February 26, 2024
• Last Verified: February 1, 2024

More Information

Terms related to this study

• Keywords: Cardiovascular Diseases; cohort; Lifestyle; physical fitness
• Additional Relevant MeSH Terms: Cardiovascular Diseases
• Other Study ID Numbers: 2023-1990

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No