The Prevalence of Sarcopenia in a Cohort of Haemodialysis Patients and Its Correlation With Mortality

The Prevalence of Sarcopenia in a Cohort of Patients With End Stage Kidney Disease on Haemodialysis Patients and Its Correlation With Mortality

The study aims to explore the correlation between the prevalence of sarcopenia and one year mortality amongst patients on maintenance hemodialysis

Study Overview

• Status: Completed
• Conditions: Sarcopenia; End-stage Renal Disease; End-stage Kidney Disease; Dialysis Dependent Chronic Kidney Disease
• Intervention / Treatment: Diagnostic test: Hand grip function testing

Detailed Description

In our study , we aim to explore the correlation between the prevalence of sarcopenia and one year mortality among patients on maintenance hemodialysis The lean muscle mass was measured using bio-impedance analysis (BIA ). The hand-grip test was used to measure the function .

Sarcopenia was defined using European Working Group on Sarcopenia in Older people (EWGSOP) definition which involves reduced muscle function and reduced muscle mass

• Study Type: Interventional
• Enrollment (Actual): 274
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Egypt
  • Cairo, Egypt
    • Kasr Alainy University Hospitals

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Child; Adult; Older Adult
• Accepts Healthy Volunteers: No

Description

Inclusion Criteria:

• Patients with End stage kidney disease on maintenance dialysis

Exclusion Criteria:

• unable to consent or terminal malignancy

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Diagnostic
• Allocation: N/A
• Interventional Model: Single Group Assignment
• Masking: None (Open Label)

Number of Arms

1

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Other: End stage kidney disease patient on maintenance hemodialysis; All patient that have been recruited with have the lean body mass index measured sing the Bio-impedance analysis ( BIA )	Diagnostic test: Hand grip function testing; The use of Bio-impedance to measure the skeletal muscle mass; Other Names: Measuring skeletal body mass using bio-impedance analysis ( BIA)

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
One year mortality	All cause mortality of patients with end stage kidney disease on hemodialysis	One year

Collaborators and Investigators

• Sponsor: Kasr El Aini Hospital
• Investigators: Principal Investigator: Tarek Abdelaziz, PhD, Kasr El Aini Hospital

Study record dates

Study Major Dates

• Study Start (Actual): February 15, 2021
• Primary Completion (Actual): May 13, 2022
• Study Completion (Actual): March 15, 2023

Study Registration Dates

• First Submitted: June 20, 2024
• First Submitted That Met QC Criteria: June 26, 2024
• First Posted (Actual): June 27, 2024

Study Record Updates

• Last Update Posted (Actual): June 27, 2024
• Last Update Submitted That Met QC Criteria: June 26, 2024
• Last Verified: June 1, 2024

More Information

Terms related to this study

• Keywords: sarcopenia; end stage renal disease; end stage kidney disease; dialysis dependent end stage renal disease
• Additional Relevant MeSH Terms: Pathologic Processes; Nervous System Diseases; Urologic Diseases; Neurologic Manifestations; Disease Attributes; Renal Insufficiency; Neuromuscular Manifestations; Pathological Conditions, Anatomical; Muscular Atrophy; Atrophy; Chronic Disease; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Kidney Diseases; Renal Insufficiency, Chronic; Kidney Failure, Chronic; Sarcopenia
• Other Study ID Numbers: MD-119-2020

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO
• IPD Plan Description: Upon reasonable request

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No