HYPERTENSIVE CRISIS AND ATMOSPHERIC PRESSURE RELATIONSHIP

HYPERTENSIVE CRISIS AND ATMOSPHERIC PRESSURE RELATIONSHIP: A PROSPECTIVE STUDY

relationship between the onset times of symptoms and the regions of patients presenting to the emergency department with hypertensive crisis (systolic ≥180 and/or diastolic ≥110 mmHg) and the fluctuations in atmospheric pressure

Study Overview

• Status: Recruiting
• Conditions: Hypertensive Urgency; Weather

Detailed Description

Hypertensive emergency is defined as grade 3 hypertension (systolic ≥180 and/or diastolic ≥110 mmHg) that causes end-organ damage, requiring urgent intervention and intensive care admission . Hypertensive crisis is described as severe hypertension not associated with end-organ damage. Some sources define hypertensive crisis as hypertension of grade 3 or higher, while others refer to it as severe hypertension without specifying a threshold .

Literature reviews, published guidelines, and studies indicate that the definitions and treatment approaches for hypertensive crisis differ between Europe and America, with variations in management from one physician to another . Seasonal blood pressure fluctuations are influenced by external temperature, indoor temperature, humidity, atmospheric pressure, and wind . Notably, during periods of low atmospheric pressure, blood pressure measurements show statistically significant increases compared to other days . Consequently, the frequency of life-threatening conditions associated with hypertension, such as intracranial hemorrhage and abdominal aortic aneurysm rupture, has been observed to increase on days when atmospheric pressure changes .

In our study, we aim to investigate the relationship between the onset times of symptoms and the regions of patients presenting to the emergency department with hypertensive crisis (systolic ≥180 and/or diastolic ≥110 mmHg) and the fluctuations in atmospheric pressure

• Study Type: Observational
• Enrollment (Estimated): 350

Contacts and Locations

• Study Contact: Name: Gulsen AKCAY, Ass. Prof.; Phone Number: +905052874949; Email: gulakcay@yahoo.com.tr
• Study Contact Backup: Name: Elif HAMZACEBIOGLU KAYISOGLU, Specialist; Phone Number: +905453300679; Email: turkuaz-61@indowslive.com

Study Locations

• Turkey
  • Ankara, Turkey, 06170
    • Recruiting
    • Etlik City Hospital
    • Contact: Elif HAMZACEBIOGLU KAYISOGLU, Specialist; Phone Number: +905453300679; Email: turkuaz-61@windowslive.com
    • Sub-Investigator: Murat OZDEMIR, specialist
    • Contact: Gulsen AKCAY, Associate Professor; Phone Number: +905052874949; Email: gulakcay@yahoo.com.tr
    • Principal Investigator: Gulsen AKCAY, Ass. Prof.
    • Principal Investigator: Elif HAMZACEBIOGLU KAYISOGLU, Specialist
    • Sub-Investigator: Fatma BUYUKCELEN CIFTCI, resident
    • Sub-Investigator: Fatma Nur KOC, Resident
    • Sub-Investigator: Bedriye Muge SONMEZ, ass. prof.

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: No

• Sampling Method: Probability Sample

Study Population

Patients admitted to emergency department with hypertensive urgency ( systolic ≥180 and/or diastolic ≥110 mmHg )

Description

Inclusion Criteria:

1. Age 18 and above
2. Hypertensive crisis (systolic ≥180 and/or diastolic ≥110 mmHg)

Exclusion Criteria:

1. Patients presenting with hypertensive emergency (those with end-organ damage)
2. Patients who have traveled to another city or district within the last 4 days
3. Pregnant patients

Study Plan

How is the study designed?

Number of groups / cohorts

1

Cohorts and Interventions

Group / Cohort
hypertension; patients admitted to emergency department with grade 3 (systolic ≥180 and/or diastolic ≥110 mmHg) blood pressure

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Hypertensive Crisis	Patients' blood pressure values evaluation in terms of atmospheric pressure and weather conditions	from enrollment to the end of follow up duration of 7 days

Collaborators and Investigators

• Sponsor: Saglik Bilimleri Universitesi
• Collaborators: Etimesgut Military Hospital
• Investigators: Study Director: Gulsen AKCAY, ass. prof., Ankara Etlik City Hospital

Publications and helpful links

General Publications

• Salvetti M, Paini A, Colonetti E, Tarozzi L, Bertacchini F, Aggiusti C, Stassaldi D, Rosei CA, Rosei EA, Muiesan ML. Hypertensive emergencies and urgencies: a single-centre experience in Northern Italy 2008-2015. J Hypertens. 2020 Jan;38(1):52-58. doi: 10.1097/HJH.0000000000002213.
• Jehn M, Appel LJ, Sacks FM, Miller ER 3rd; DASH Collaborative Research Group. The effect of ambient temperature and barometric pressure on ambulatory blood pressure variability. Am J Hypertens. 2002 Nov;15(11):941-5. doi: 10.1016/s0895-7061(02)02999-0.
• Modesti PA, Morabito M, Massetti L, Rapi S, Orlandini S, Mancia G, Gensini GF, Parati G. Seasonal blood pressure changes: an independent relationship with temperature and daylight hours. Hypertension. 2013 Apr;61(4):908-14. doi: 10.1161/HYPERTENSIONAHA.111.00315. Epub 2013 Feb 4.

Study record dates

Study Major Dates

• Study Start (Actual): September 15, 2024
• Primary Completion (Estimated): September 15, 2025
• Study Completion (Estimated): September 15, 2025

Study Registration Dates

• First Submitted: October 8, 2024
• First Submitted That Met QC Criteria: October 8, 2024
• First Posted (Actual): October 10, 2024

Study Record Updates

• Last Update Posted (Actual): October 10, 2024
• Last Update Submitted That Met QC Criteria: October 8, 2024
• Last Verified: October 1, 2024

More Information

Terms related to this study

• Keywords: hypertension; hypertensive urgency; atmospheric pressure
• Additional Relevant MeSH Terms: Cardiovascular Diseases; Vascular Diseases; Hypertension; Hypertensive Crisis
• Other Study ID Numbers: Hypertension, ATM pressure

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No