Glutamate Modulation of tDCS Over Premotor Cortex Combined With Peripheral Nerve Stimulation Promoted Observation-execution-related Cortical Excitability and Motor Learning

November 15, 2024 updated by: Beijing Sport University
This study aimed to investigate whether concurrent tDCS over the PMC and PNS during action observation enhance observation-execution-related motor cortex excitability and improve motor performance, and to explore the underlying mechanism

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Actual)

128

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • China
    • Haidian
      • Beijing, Haidian, China, 100084
        • Beijing Sport University

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult

Accepts Healthy Volunteers

Yes

Description

Inclusion Criteria:

  • normal or corrected-to-normal vision
  • right-handed

Exclusion Criteria:

  • pregnancy
  • a history of epilepsy
  • implanted medical devices
  • history or presence of neurological, psychiatric or musculoskeletal disorders, other medical conditions, and left-handedness

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Basic Science
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Single

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: tDCS + PNS with action observation
Device: tDCS + PNS without action observation
tDCS: transcranial direct current stimulation; PNS: peripheral nerve stimulation
Experimental: sham tDCS + sham PNS with action observation
Device: sham tDCS + sham PNS with action observation
tDCS: transcranial direct current stimulation; PNS: peripheral nerve stimulation
Experimental: tDCS + PNS without action observation
Device: sham tDCS + PNS with action observation
tDCS: transcranial direct current stimulation; PNS: peripheral nerve stimulation
Active Comparator: sham tDCS + PNS with action observation
Device: tDCS + PNS with action observation
tDCS: transcranial direct current stimulation; PNS: peripheral nerve stimulation
Active Comparator: tDCS + sham PNS with action observation
Device: tDCS + sham PNS with action observation
tDCS: transcranial direct current stimulation; PNS: peripheral nerve stimulation

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
Motor-evoked potentials
Time Frame: Before interventions, and immediately after interventions
Before interventions, and immediately after interventions
intracortical facilitation assessed by transcranial magnetic stimulation
Time Frame: Before interventions, and immediately after interventions
Before interventions, and immediately after interventions
short-interval intracortical inhibition assessed by transcranial magnetic stimulation
Time Frame: Before interventions, and immediately after interventions
Before interventions, and immediately after interventions
Reaction times of action execution blocks
Time Frame: immediately after interventions
immediately after interventions

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Beijing Sport University

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

October 17, 2017

Primary Completion (Actual)

October 14, 2018

Study Completion (Actual)

October 14, 2018

Study Registration Dates

First Submitted

November 13, 2024

First Submitted That Met QC Criteria

November 15, 2024

First Posted (Estimated)

November 19, 2024

Study Record Updates

Last Update Posted (Estimated)

November 19, 2024

Last Update Submitted That Met QC Criteria

November 15, 2024

Last Verified

November 1, 2024

More Information

Terms related to this study

Other Study ID Numbers

  • GMOTOPCCWPNSPOERCEAML

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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