Preliminary Explorative Study of Magnetic Resonance-Guided Focused Ultrasound Surgery in Refractory Obsessive-Compulsive Disorder Patients

The goal of this clinical trial is to evaluate If magnetic resonance-guided focused ultrasound works to treat refractory obsessive-compulsive disorder in adults. The main questions it aims to answer are:

• What effectiveness does the magnetic resonance-guided focused ultrasound bring to the participants during study period?
• What side effects do the participant have when treated with magnetic resonance-guide focused ultrasound?

Participants will:

• Finish scales to evaluate participants' level of cognitive function, depression and Compulsiveness.
• Receive the treatment of magnetic resonance-guided focused ultrasound
• Take the fMRI brain scanning before and after the treatment
• Recovering

Study Overview

• Status: Enrolling by invitation
• Conditions: Obsessive-Compulsive Disorder (OCD)
• Intervention / Treatment: Procedure: magnetic resonance-guided focused ultrasound surgery, MRgFUS

• Study Type: Interventional
• Enrollment (Estimated): 10
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Taiwan
  • Taipei, Taiwan
    • National Taiwan University Hospital

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: No

Description

Inclusion Criteria:

• For 30 days before enrollment, the type and dosage of primary OCD medications (including antidepressants and adjunctive medications such as antipsychotics and tricyclic antidepressants) remain unchanged. However, other symptom-relief medications, such as anti-anxiety drugs, are not restricted.
• Diagnosed by a psychiatrist through a diagnostic interview, meeting the criteria for OCD according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) for at least five years; and scoring above 28 on the Chinese version of the Yale-Brown Obsessive Compulsive Scale (Y-BOCS).

• OCD symptoms show limited improvement with existing treatments, classified as refractory according to the OCD Clinical Practice Review Task Force of the Anxiety & Depression Association of America (ADAA):

  i. Received treatment with at least three different antidepressants at adequate doses and durations.

ii. Received treatment with at least two of the following medications for over a month each: antipsychotics, clonazepam, lithium, buspirone.

iii. Underwent appropriate cognitive-behavioral therapy with exposure and response prevention (EX/RP) for at least 20 sessions.

• Able to comply with focused ultrasound-related operational instructions (device: ExAblate MRgFUS). During the procedure, participants must be able to communicate with the physician and express their sensory experiences (general anesthesia is not required).
• After explanation by a psychiatrist and neurosurgeon, participants provide informed consent and can comply with the research process and related guidance. During the trial, participants must be able to independently press the stop-ultrasound button.

Exclusion Criteria:

- Major and Potential Physical Conditions That May Affect the Treatment Process: i. Cardiovascular or hemodynamic abnormalities, such as heart failure, arrhythmias, tachycardia or bradycardia (>100 bpm, <60 bpm), abnormal systolic blood pressure (>180 mmHg, <90 mmHg), abnormal diastolic blood pressure (>180 mmHg), and severe hypertension uncontrolled by medication (diastolic blood pressure >100 mmHg after stable medication use). Additionally, those who have taken medications affecting autonomic regulation and potentially impacting vital sign stability within six months before treatment (however, antidepressants and antipsychotics taken for mental illness are not included).

ii. Platelet or coagulation disorders or currently taking anticoagulant medications (e.g., Warfarin, Avastin).

iii. Renal dysfunction (eGFR < 30ml/min/1.73 m²) or currently undergoing hemodialysis.

iv. Severe infections. v. Immunocompromised individuals. vi. History of intracranial hemorrhage, intracranial aneurysm, cerebrovascular events within six months, or brain tumors.

vii. Neurological disorders: stroke, epilepsy, suspected increased intracranial pressure (IICP), Parkinson's disease and related disorders (Multisystem atrophy, Progressive supranuclear palsy, Dementia with Lewy bodies, Alzheimer's disease).

viii. Other clinically assessed physical conditions that may pose significant risks to bodily functions and life during the treatment process.

• Patients deemed unsuitable for magnetic resonance-guided focused ultrasound after evaluation, including those with low skull density ratio (<0.4), intracranial implants, or structures that cannot avoid energy-absorbing or sensitive tissues in the ultrasound path (e.g., previous brain shunt sites, surgical metal clips, significant calcification, extensive scarring, or any rigid implants). (Pre-treatment evaluation will include a head CT scan to calculate the skull density ratio (SDR) to determine suitability for focused ultrasound treatment; a low SDR may affect the efficiency of the treatment and increase side effects, making the patient unsuitable for treatment.)
• Bilateral structural abnormalities in the anterior limb of the internal capsule (ALIC).
• Contraindications to MRI or its contrast agents, or incompatible metal implants in the body.
• Inability to comply with treatment instructions, lack of behavioral capacity, or lack of treatment motivation.
• Major psychiatric comorbidities: schizophrenia spectrum disorders, acute episodes, bipolar disorder, acute episodes, severe dementia, unresolved alcohol or substance abuse, recent suicidal ideation or plans.
• Pregnancy or breastfeeding.
• Scalp atrophy or difficulty healing scalp wounds.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: N/A
• Interventional Model: Single Group Assignment
• Masking: None (Open Label)

Number of Arms

1

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Experimental	Procedure: magnetic resonance-guided focused ultrasound surgery, MRgFUS; Magnetic Resonance-Guided Focused Ultrasound Surgery The clinical symptoms, brain imaging, and cognitive function status were followed up for 2 years before and after surgery.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
Number of Participants with Serious and Non-Serious Adverse Events	For two years after the surgery

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Clinical Symptoms	Chinese version of the Yale-Brown Obsessive-Compulsive Scale, Chinese version of the Montgomery Depression Scale, Chinese version of the Hamilton Anxiety Scale.	For two years after the surgery
Structural Brain Imaging		For two years after the surgery

Collaborators and Investigators

• Sponsor: National Taiwan University Hospital

Study record dates

Study Major Dates

• Study Start (Actual): January 1, 2024
• Primary Completion (Estimated): December 31, 2026
• Study Completion (Estimated): December 31, 2026

Study Registration Dates

• First Submitted: December 26, 2024
• First Submitted That Met QC Criteria: February 3, 2025
• First Posted (Actual): February 10, 2025

Study Record Updates

• Last Update Posted (Actual): March 17, 2026
• Last Update Submitted That Met QC Criteria: March 15, 2026
• Last Verified: March 1, 2026

More Information

Terms related to this study

• Keywords: functional magnetic resonance imaging; Magnetic Resonance-Guided Focused Ultrasound; Refractory Obsessive-Compulsive Disorder; anterior limb of the internal capsule
• Additional Relevant MeSH Terms: Mental Disorders; Anxiety Disorders; Obsessive-Compulsive Disorder
• Other Study ID Numbers: 202307078DIND

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: UNDECIDED

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No
• product manufactured in and exported from the U.S.: No