Endoscopic Findings in Patients With Upper GIT Bleeding

Endoscopic Findings in Patients With Upper GIT Bleeding in Assiut University Hospital

This study aims to identify the causes of upper gastrointestinal bleeding through comprehensive evaluation via upper endoscopy in Assiut University Hospital and contribute valuable insights into effective management strategies.

Study Overview

• Status: Not yet recruiting
• Conditions: GIT - Gastrointestinal Tract Hemorrhage
• Intervention / Treatment: Device: endoscope

Detailed Description

Upper gastrointestinal bleeding (UGIB) is a critical medical situation that arises when there is bleeding proximal to the ligament of Treitz [1]. This condition is a leading cause of morbidity and mortality, with death rates ranging from 5-14% and increasing to over 40% in patients with liver disease[2] Symptoms of UGIB may include anemia, hematemesis, melena, or hematochezia [3].

Neoplasms, arteriovenous malformations, esophageal varices, gastric ulcers, gastric erosions, duodenal ulcers, reflux esophagitis, Mallory-Weiss tears, and fundal varices are causes of UGIB [4].

Current strategies for managing UGIB emphasize early recognition and intervention. Endoscopy is the primary diagnostic and therapeutic modality, allowing for direct visualization of the gastrointestinal tract and enabling interventions such as cauterization, clipping, or band ligation to control bleeding [5]. Recent advancements in endoscopic techniques have improved outcomes by facilitating earlier detection and treatment of UGIB episodes. For instance, the use of hemostatic powders and over-the-scope clips has shown promise in managing refractory cases[6,7].

Endoscopic therapies may have resulted in earlier detection and treatment of UGIB, which could have led to a reduction in the incidence and severity of the condition. Upper GI endoscopy is considered the primary modality for identifying the underlying etiology and administering appropriate therapeutic measures to the patient present with upper GIT bleeding by ligation ,clips, electrocoagulation or by taking biopsies that help in diagnosis. The rationale for this research stems from the need to enhance understanding of UGIB's underlying causes and improve patient outcomes through timely endoscopic intervention. By identifying specific etiologies through upper endoscopy[8,9].

• Study Type: Observational
• Enrollment (Estimated): 100

Contacts and Locations

• Study Contact: Name: Ebram Sala,ma; Phone Number: 01280541696; Email: Ebram.14223993@med.aun.edu.eg
• Study Contact Backup: Name: Abd alhamed mhamed; Phone Number: 01012125291; Email: abdon33@aun.edu.eg

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: N/A

• Sampling Method: Non-Probability Sample

Study Population

2.4.1- Type of the study: Prospective cross-sectional study .

2.4. 2- Study Setting: Assiut University Hospital , Alraghy Hospital, Endoscopy centre.

2.4. 3- Study subjects:

1. Inclusion criteria:

   Adult patients present with upper GIT bleeding of both gender older than 18 years old

2. Exclusion criteria:

   1. Patients younger than 18
   2. Pregnant women
   3. patients with end stage disease that not fit for endoscopic intervention

Description

Inclusion Criteria:

• Adult patients present with upper GIT bleeding of both gender older than 18 years old

Exclusion Criteria:

• 1- Patients younger than 18 2- Pregnant women 3- patients with end stage disease that not fit for endoscopic intervention

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Endoscopic Findings in patients with upper GIT Bleeding	identify the causes of upper gastrointestinal bleeding through comprehensive evaluation via upper endoscopy in Assuit University Hospital and contribute valuable insights into effective management strategies.	one year

Collaborators and Investigators

• Sponsor: Assiut University

Publications and helpful links

General Publications

• Elsebaey MA, Elashry H, Elbedewy TA, Elhadidy AA, Esheba NE, Ezat S, Negm MS, Abo-Amer YE, Abgeegy ME, Elsergany HF, Mansour L, Abd-Elsalam S. Predictors of in-hospital mortality in a cohort of elderly Egyptian patients with acute upper gastrointestinal bleeding. Medicine (Baltimore). 2018 Apr;97(16):e0403. doi: 10.1097/MD.0000000000010403.

Study record dates

Study Major Dates

• Study Start (Estimated): March 1, 2025
• Primary Completion (Estimated): March 1, 2026
• Study Completion (Estimated): March 1, 2027

Study Registration Dates

• First Submitted: March 15, 2025
• First Submitted That Met QC Criteria: March 15, 2025
• First Posted (Actual): March 25, 2025

Study Record Updates

• Last Update Posted (Actual): March 25, 2025
• Last Update Submitted That Met QC Criteria: March 15, 2025
• Last Verified: March 1, 2025

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Pathologic Processes; Digestive System Diseases; Gastrointestinal Diseases; Hemorrhage; Gastrointestinal Hemorrhage
• Other Study ID Numbers: Endoscope in GIT bleeding

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No