Mining the Gut Microbiota of Adults for Health-relevant Microbial Signatures.

Identification of Gut Microbiota Signatures Associated With Health Metrics in a Community-based Adult Cohort: a Cross-sectional Study

Mining the gut microbiota of adults for health-relevant microbial signatures.

Study Overview

• Status: Completed
• Conditions: Adult
• Intervention / Treatment: Other: Observational, non-interventional study.

Detailed Description

This study is a community-based, observational cross-sectional investigation, enrolling 1,530 middle-aged and elderly volunteers.

Data were collected through a systematic, multi-dimensional assessment, which included:

Biospecimen Collection: Blood, urine, and stool samples were obtained from the volunteers.

Physical and Imaging Examinations: Procedures included anthropometric measurements, vital sign monitoring, oral examinations, electrocardiograms, physical examinations of key organs, and abdominal ultrasonography.

Psychological and Cognitive Assessments: Standardized scales were administered to assess anxiety/depression and memory function.

All clinical and questionnaire data were processed through standardized procedures, forming a comprehensive health database for subsequent analysis.

• Study Type: Observational
• Enrollment (Actual): 1530

Contacts and Locations

Study Locations

• China
  • Guangdong
    • Guangzhou, Guangdong, China, 510000
      • Zhujiang Hospital of Southern Medical University

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: Yes

• Sampling Method: Non-Probability Sample

Study Population

Meet eligibility criteria

Description

Inclusion Criteria：

• Community-dwelling adults aged 30 to 95 years.
• Individuals who underwent an annual health examination at the Health Management Center of Huzhou Central Hospital during the specified time period.
• Ability to comprehend the study content and voluntarily provide signed informed consent.
• Willingness and ability to provide the required biospecimens (blood, urine, stool).

Exclusion Criteria:

• Concurrent participation in another interventional clinical trial that is likely to interfere with the results of this study.
• Voluntary withdrawal from the study.

Study Plan

How is the study designed?

Number of groups / cohorts

1

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
adult volunteers; The study population consists of 1,530 middle-aged and elderly volunteers from the same community who underwent comprehensive health examinations at Huzhou Central Hospital . All participants completed a multi-dimensional assessment including biospecimen collection, physical/imaging examinations, and psychometric evaluations.	Other: Observational, non-interventional study.; Observational, non-interventional study.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Identification of Health-Relevant Signatures in Adults	Primary Outcome Measure 1)Change in standard laboratory parameters from baseline:Changes in routine laboratory parameters measured in blood, urine, and stool samples, including complete blood count and standard serum biochemistry panels.Unit of Measure: Various laboratory units (e.g., g/L, U/L, mmol/L); 2) Change in anthropometric measurements from baseline: Anthropometric measurements including body weight (kg), height (m), and body mass index (BMI, kg/m²).Unit of Measure:kg, m, kg/m²; 3) Alcohol consumption status: Alcohol consumption status assessed by self- report, categorized as current drinker or non-drinker at enrollment.Unit of Measure:Categorical (yes/no); 4) Hospital Anxiety and Depression Scale (HADS) scores: Anxiety and depression symptom severity assessed using the Hospital Anxiety and Depression Scale, including anxiety and depression subscale scores.Unit of Measure:Score on a standardized scale.	Baseline

Collaborators and Investigators

• Sponsor: Zhujiang Hospital
• Collaborators: Huzhou Central Hospital

Study record dates

Study Major Dates

• Study Start (Actual): August 15, 2021
• Primary Completion (Actual): August 30, 2021
• Study Completion (Actual): September 29, 2021

Study Registration Dates

• First Submitted: December 3, 2025
• First Submitted That Met QC Criteria: January 7, 2026
• First Posted (Actual): January 15, 2026

Study Record Updates

• Last Update Posted (Actual): January 15, 2026
• Last Update Submitted That Met QC Criteria: January 7, 2026
• Last Verified: December 1, 2025

More Information

Terms related to this study

• Other Study ID Numbers: Zhujiang-Huzhou

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No