Focused Shockwave (ESWT), Radial Pressure Waves (EPAT), And Electromagnetic Transduction Therapy (EMTT) For Lower Extremity Musculoskeletal Injuries

May 15, 2026 updated by: Elizabeth Bondi, Mayo Clinic
The purpose of this study is to assess the efficacy of ESWT, EPAT, EMTT and the combination of these therapies in treating patients with lower extremity soft tissue, cartilage, and bone injuries.

Study Overview

Status

Active, not recruiting

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Estimated)

200

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • United States
    • Minnesota
      • Rochester, Minnesota, United States, 55905
        • Mayo Clinic in Rochester

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Description

Inclusion Criteria:

• Men and women > 18 with lower extremity musculoskeletal injury confirmed by physician

Exclusion Criteria:

  • All devices: Patients with active cancer or who may be pregnant.
  • For EMTT only, patients with shrapnel, metal in the body, pacemaker, or non-MRI compatible implantable devices.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Non-Randomized
  • Interventional Model: Parallel Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: shock wave only
Device: Shock wave
shockwave
Experimental: shock wave + radial pressure wave
Device: Shock wave
shockwave
Device: Radial pressure waves
Pressure waves
Experimental: EMTT
Device: Electromagnetic transduction therapy (EMTT)
EMTT
Experimental: shock wave + EMTT
Device: Shock wave
shockwave
Device: Electromagnetic transduction therapy (EMTT)
EMTT

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
VAS
Time Frame: initial, 6weeks, 3 months, 6 months, 1 year
initial, 6weeks, 3 months, 6 months, 1 year

Secondary Outcome Measures

Outcome Measure
Time Frame
FAAM
Time Frame: baseline, 6 week, 3 month, 6 month 1 year
baseline, 6 week, 3 month, 6 month 1 year

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Mayo Clinic

Investigators

  • Principal Investigator: Elizabeth Bondi, Mayo Clinic

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

Helpful Links

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

March 15, 2026

Primary Completion (Estimated)

April 1, 2035

Study Completion (Estimated)

April 1, 2035

Study Registration Dates

First Submitted

April 6, 2026

First Submitted That Met QC Criteria

April 6, 2026

First Posted (Actual)

April 13, 2026

Study Record Updates

Last Update Posted (Actual)

May 18, 2026

Last Update Submitted That Met QC Criteria

May 15, 2026

Last Verified

April 1, 2026

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 25-011219

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

Yes

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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