Efficacy Test of a Moisturizing and Anti-aging Facial Mask

Efficacy Test of a Moisturizing and Anti-aging Facial Mask for Skin Improvement

The objective of this study is to evaluate the effect of Moisturizing facial mask and Anti-aging facial mask on human skin condition improvement.

Study Overview

• Status: Active, not recruiting
• Conditions: Skin Condition; Skin Hydration; Anti Skin Aging
• Intervention / Treatment: Other: Hydrating Repairing Mask; Other: Anti-aging Rejuvenating Mask

Detailed Description

This study is a single-center, self-controlled human trial designed to evaluate the skin beauty effect of Moisturizing facial mask and Anti-aging facial mask.

Healthy adult participants aged above 18 years will be enrolled. Participants will be informed to apply the facial mask on whole face three times per week for 4 consecutive weeks. Skin measurement and self-assessment questionnaires will be conducted at baseline (before intake), after single use, and after continuous use for 2 and 4 weeks.

• Study Type: Interventional
• Enrollment (Actual): 60
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Taiwan
  • Pingdong, Taiwan
    • Chia Nan University of Pharmacy & Science

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: Yes

Description

Inclusion Criteria:

• Participants aged 18 years or older

Exclusion Criteria:

• Non-voluntary participants.
• Individuals diagnosed by a physician with skin diseases, liver cirrhosis, or chronic renal failure.
• Individuals with known allergies to cosmetics, medications, or foods.
• Pregnant or breastfeeding individuals.
• Individuals taking medications for chronic diseases.
• Students taught or supervised by the principal investigator.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: Non-Randomized
• Interventional Model: Parallel Assignment
• Masking: None (Open Label)

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Hydrating Repairing Mask	Other: Hydrating Repairing Mask; Applying the facial mask three times per week for a continuous period of 4 weeks; Other Names: seibella Hydrating Repairing Mask
Experimental: Anti-aging Rejuvenating Mask	Other: Anti-aging Rejuvenating Mask; Applying the facial mask three times per week for a continuous period of 4 weeks; Other Names: seibella Anti-aging Rejuvenating Mask

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
The change of skin hydration	Corneometer® CM825 (CK, Germany) was utilized to measure skin surface hydation. Units: arbitrary Corneometer® units 0-120.	Change from Baseline skin hydration at 4 weeks
The change of skin redness	Chroma Meter MM500 was utilized to measure face skin redness. Units: a* value	Change from Baseline skin redness at 4 weeks
The change of skin texture	VISIA Complexion Analysis was utilized to measure skin texture. Units: arbitrary units	Change from Baseline skin texture at 4 weeks
The change of skin wrinkles	VISIA Complexion Analysis was utilized to measure skin wrinkles. Units: arbitrary units	Change from Baseline skin wrinkles at 4 weeks

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
The change of transepidermal water loss (TEWL)	Tewameter® TM300 (CK, Germany) was utilized to measure TEWL. Units: g/hm²	Change from Baseline TEWL at 4 weeks
The change of skin tone	Chroma Meter MM500 was utilized to measure face skin tone. Units: Individual Typology Angle (ITA°)	Change from Baseline skin tone at 4 weeks
The change of skin pores	VISIA Complexion Analysis was utilized to measure skin pores. Units: arbitrary units	Change from Baseline skin pores at 4 weeks
The change of skin elasticity	Skin elasticity (Softplus, Italy) was utilized to measure face skin elasticity. Units: arbitrary units	Change from Baseline skin elasticity at 4 weeks
The change of skin collagen density	DermaLab® Series SkinLab Combo was utilized to measure skin collagen density. Units: arbitrary units	Change from Baseline skin collagen density at 4 weeks

Other Outcome Measures

Outcome Measure	Measure Description	Time Frame
The change of self-assessment skin condition	Skin condition was evaluated using a 5-point Likert scale (0-4) to assess the severity of skin-related symptoms. The scale was defined as follows: 0 = none, 1 = mild, 2 = moderate, 3 = severe, and 4 = very severe.	Change from Baseline skin condition at 4 weeks

Collaborators and Investigators

• Sponsor: TCI Co., Ltd.
• Investigators: Principal Investigator: Chia-Hua Liang, Ph.D., Chia Nan University of Pharmacy & Science

Study record dates

Study Major Dates

• Study Start (Actual): April 29, 2026
• Primary Completion (Estimated): June 15, 2026
• Study Completion (Estimated): July 31, 2026

Study Registration Dates

• First Submitted: May 26, 2026
• First Submitted That Met QC Criteria: May 26, 2026
• First Posted (Actual): June 3, 2026

Study Record Updates

• Last Update Posted (Actual): June 3, 2026
• Last Update Submitted That Met QC Criteria: May 26, 2026
• Last Verified: May 1, 2026

More Information

Terms related to this study

• Keywords: Skin hydration; Facial mask; Anti skin aging; Skin soothing
• Additional Relevant MeSH Terms: Skin and Connective Tissue Diseases; Skin Diseases
• Other Study ID Numbers: TMANH114-REC056

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No