Clinical Trials: SEARCH[Study] TILT[Study:StudyFirstPostDate] AREA[ConditionSearch] Dementia
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NCTID/Status
Study
Last Changed
2851
NCT04120493
Recruiting
Recruiting
Safety and Proof-of-Concept (POC) Study With AMT-130 in Adults With Early Manifest Huntington Disease
Conditions: Huntington Disease
Intervention: RAAV5-miHTT, Imitation Surgery
Conditions: Huntington Disease
Intervention: RAAV5-miHTT, Imitation Surgery
November 13, 2019
2852
NCT00066157
Completed
Completed
Alzheimer's Disease: Therapeutic Potential of Estrogen
Conditions: Alzheimer Disease
Intervention: Transdermal Estradiol, Medroxyprogesterone, Placebo Patch, Placebo
Conditions: Alzheimer Disease
Intervention: Transdermal Estradiol, Medroxyprogesterone, Placebo Patch, Placebo
August 22, 2018
2853
NCT00065767
Completed
Completed
Cognitive and Neurophysiological Effects of Raloxifene in Alzheimer's Disease
Conditions: Alzheimer Disease
Intervention: Raloxifene
Conditions: Alzheimer Disease
Intervention: Raloxifene
October 1, 2015
2854
NCT04102579
Recruiting
Recruiting
Efficacy, Safety, and Tolerability of Valbenazine for the Treatment of Chorea Associated With Huntington's Disease
Conditions: Chorea, Huntington
Intervention: Valbenazine, Placebo
Conditions: Chorea, Huntington
Intervention: Valbenazine, Placebo
October 31, 2019
2855
NCT04071639
Recruiting
Recruiting
Symptomatic Therapy for Patients With Huntington's Disease
Conditions: Huntington Disease
Intervention: Haloperidol, Risperidone, Zoloft, Coenzyme Q10
Conditions: Huntington Disease
Intervention: Haloperidol, Risperidone, Zoloft, Coenzyme Q10
September 9, 2019
2856
NCT00063310
Completed
Completed
ALADDIN Study: Antigonadotropin-Leuprolide in Alzheimer's Disease Drug INvestigation
Conditions: Alzheimer Disease
Intervention: Leuprolide Acetate
Conditions: Alzheimer Disease
Intervention: Leuprolide Acetate
December 10, 2009
2857
NCT00062569
Completed
Completed
Bathing Persons With Alzheimer's Disease aT Home (The BATH Study)
Conditions: Alzheimer Disease
Intervention: Bathing Support Intervention (BSI), Caregiver Reminiscence With Coaching
Conditions: Alzheimer Disease
Intervention: Bathing Support Intervention (BSI), Caregiver Reminiscence With Coaching
March 10, 2009
2858
NCT04012411
Not yet recruiting
Not yet recruiting
Study of BDNF Pathway Biomarkers in the Cerebrospinal Fluid in Patients With Huntington's Disease
Conditions: Huntington Disease
Intervention: Brain MRI, Lumbar Punction, Blood Sample, Cognitive Evaluation
Conditions: Huntington Disease
Intervention: Brain MRI, Lumbar Punction, Blood Sample, Cognitive Evaluation
July 11, 2019
2859
NCT04000594
Recruiting
Recruiting
A Study to Investigate the Pharmacokinetics and Pharmacodynamics of RO7234292 (RG6042) in CSF and Plasma, and Safety and Tolerability Following Intrathecal Administration in Patients With Huntington's Disease
Conditions: Huntingtons Disease
Intervention: RO7234292 (RG6042)
Conditions: Huntingtons Disease
Intervention: RO7234292 (RG6042)
November 25, 2019
2860
NCT00059410
Completed
Completed
Alzheimer's Disease Treatment and Illness Perceptions Survey (TIPS) II
Conditions: Alzheimer Disease
Conditions: Alzheimer Disease
December 10, 2009
2861
NCT03980938
Recruiting
Recruiting
Within Subject Crossover Study of Cognitive Effects of Neflamapimod in Early-Stage Huntington Disease
Conditions: Huntington Disease
Intervention: Neflamapimod, Placebo
Conditions: Huntington Disease
Intervention: Neflamapimod, Placebo
July 15, 2019
2862
NCT00056225
Completed
Completed
VITAL - VITamins to Slow ALzheimer's Disease (Homocysteine Study)
Conditions: Alzheimer's Disease
Intervention: Folate, Vitamin B6, Vitamin B12
Conditions: Alzheimer's Disease
Intervention: Folate, Vitamin B6, Vitamin B12
June 10, 2009
2863
NCT00053599
Completed
Completed
Cholesterol Lowering Agent to Slow Progression (CLASP) of Alzheimer's Disease Study
Conditions: Alzheimer Disease
Intervention: Simvastatin
Conditions: Alzheimer Disease
Intervention: Simvastatin
July 24, 2009
2864
NCT00051909
Completed
Completed
Efficacy and Safety of LY451395 in Patients With Probable Alzheimer's Disease
Conditions: Alzheimer's Disease
Intervention: LY451395
Conditions: Alzheimer's Disease
Intervention: LY451395
July 18, 2006
2865
NCT03854019
Recruiting
Recruiting
Evaluating the Efficacy of Dextromethorphan/Quinidine in Treating Irritability in Huntington's Disease
Conditions: Huntington Disease; Irritability
Intervention: Dextromethorphan/quinidine 20mg/10mg (DM/Q 20mg/10mg), Placebo
Conditions: Huntington Disease; Irritability
Intervention: Dextromethorphan/quinidine 20mg/10mg (DM/Q 20mg/10mg), Placebo
April 17, 2019
2866
NCT03842969
Recruiting
Recruiting
An Open-Label Extension Study to Evaluate Long-Term Safety and Tolerability of RO7234292 (RG6042) in Huntington's Disease Patients Who Participated in Prior Roche and Genentech Sponsored Studies
Conditions: Huntington Disease
Intervention: RO7234292 (RG6042)
Conditions: Huntington Disease
Intervention: RO7234292 (RG6042)
November 25, 2019
2867
NCT00001977
Completed
Completed
The Effect of Acetylcholine on Memory and Attention
Conditions: Alzheimer's Disease; Healthy
Conditions: Alzheimer's Disease; Healthy
March 3, 2008
2868
NCT03810898
Not yet recruiting
Not yet recruiting
iMagemHTT: FIH Evaluation of Novel Mutant Huntingtin PET Radioligands [¹¹C]CHDI-00485180-R and [¹¹C]CHDI-00485626
Conditions: Huntington Disease
Conditions: Huntington Disease
October 30, 2019
2869
NCT03787758
Completed
Completed
A Study to Evaluate Safety, Tolerability, and Pharmacokinetics of SAGE-718 Oral Solution in Patients With Huntington's Disease - Part B
Conditions: Huntington Disease
Intervention: SAGE-718
Conditions: Huntington Disease
Intervention: SAGE-718
November 15, 2019
2870
NCT03764215
Recruiting
Recruiting
December 3, 2018
2871
NCT03761849
Recruiting
Recruiting
A Study to Evaluate the Efficacy and Safety of Intrathecally Administered RO7234292 (RG6042) in Patients With Manifest Huntington's Disease
Conditions: Huntingtons Disease
Conditions: Huntingtons Disease
November 12, 2019
2872
NCT03713892
Recruiting
Recruiting
CKD-504 in SAD and MAD in Healthy Korean and Caucasian Adult Male and Female Subjects
Conditions: Huntington Disease
Intervention: CKD-504, Placebo
Conditions: Huntington Disease
Intervention: CKD-504, Placebo
October 18, 2018
2873
NCT03709173
Completed
Completed
October 28, 2019
2874
NCT00042172
Completed
Completed
Treatment for Early Memory Loss
Conditions: Cognition Disorders; Alzheimer Disease
Intervention: Donepezil, Ginkgo Biloba Extract
Conditions: Cognition Disorders; Alzheimer Disease
Intervention: Donepezil, Ginkgo Biloba Extract
February 27, 2014
2875
NCT03664804
Active, not recruiting
Active, not recruiting
Study to Measure Cerebrospinal Fluid Mutant Huntingtin Protein in Participants With Early Manifest Stage I or Stage II Huntington's Disease
Conditions: Huntington's Disease
Intervention: No Study Drug Was Administered In This Study
Conditions: Huntington's Disease
Intervention: No Study Drug Was Administered In This Study
November 25, 2019
2876
NCT00040378
Completed
Completed
Prevention of Alzheimer's Disease by Vitamin E and Selenium (PREADVISE)
Conditions: Alzheimer Disease
Intervention: Alphatocopherol, Selenium, Placebo Replacement For Vitamin E, Placebo Replacement For Selenium
Conditions: Alzheimer Disease
Intervention: Alphatocopherol, Selenium, Placebo Replacement For Vitamin E, Placebo Replacement For Selenium
March 12, 2018
2877
NCT00039702
Completed
Completed
March 3, 2008
2878
NCT03628235
Not yet recruiting
Not yet recruiting
HD-Charge: Indirect and Out-of-Pocket Costs of Huntington's Disease in the United States
Conditions: Huntington's Disease
Intervention: Online Survey
Conditions: Huntington's Disease
Intervention: Online Survey
February 21, 2019
2879
NCT01454453
Terminated
Terminated
Optimisation of Antipsychotic Drug Use in Older People
Conditions: Alzheimer's Disease; Schizophrenia
Intervention: Patients- Dose Titration
Conditions: Alzheimer's Disease; Schizophrenia
Intervention: Patients- Dose Titration
April 18, 2017
2880
NCT03599076
Recruiting
Recruiting
Wearable Sensors for Quantitative Assessment of Motor Impairment in Huntington's Disease Huntington's Disease
Conditions: Huntington Disease
Intervention: HD Wear
Conditions: Huntington Disease
Intervention: HD Wear
January 22, 2019
2881
NCT00034567
Completed
Completed
Healthy Aging and Memory Study
Conditions: Alzheimer Disease
Conditions: Alzheimer Disease
September 14, 2007
2882
NCT02502253
Recruiting
Recruiting
BDPP Treatment for Mild Cognitive Impairment (MCI) and Prediabetes or Type 2 Diabetes Mellitus (T2DM)
Conditions: Mild Cognitive Impairment; Alzheimer's Disease
Intervention: Grape Seed Polyphenolic Extract, Resveratrol
Conditions: Mild Cognitive Impairment; Alzheimer's Disease
Intervention: Grape Seed Polyphenolic Extract, Resveratrol
October 11, 2019
2883
NCT03575676
Completed
Completed
Efficacy and Safety of SOM3355 in Huntington's Disease Chorea
Conditions: Huntington's Chorea
Intervention: SOM3355 100mg BID, SOM3355 200mg BID, Placebo BID
Conditions: Huntington's Chorea
Intervention: SOM3355 100mg BID, SOM3355 200mg BID, Placebo BID
September 13, 2019
2884
NCT02501876
Completed
Completed
Type 2 Diabetes Mellitus as Catalyst for Alzheimer's Disease
Conditions: Alzheimer´s Disease; Diabetes Mellitus Type 2
Intervention: There Is A Retrospectiv Observational Study. No Intervention
Conditions: Alzheimer´s Disease; Diabetes Mellitus Type 2
Intervention: There Is A Retrospectiv Observational Study. No Intervention
April 11, 2017
2885
NCT00031018
Unknown status
Unknown status
Prevention of Cognitive Decline in Alzheimer's Disease by Ingested Interferon Alpha
Conditions: Memory Disorders; Alzheimer's Disease
Intervention: Aricept, IFN-alpha2A
Conditions: Memory Disorders; Alzheimer's Disease
Intervention: Aricept, IFN-alpha2A
February 4, 2008
2886
NCT03515213
Active, not recruiting
Active, not recruiting
Safety and Efficacy of Fenofibrate as a Treatment for Huntington's Disease
Conditions: Huntington Disease
Conditions: Huntington Disease
March 5, 2019
2887
NCT03434548
Not yet recruiting
Not yet recruiting
Huntington's Disease 123
Conditions: Huntington Disease
Conditions: Huntington Disease
September 14, 2018
2888
NCT03417583
Recruiting
Recruiting
Assessing Efficacy of Neuropsychiatric Assessment and Treatment Protocols in Huntington's Disease Patients
Conditions: Huntington Disease
Intervention: Protocol Intervention Group
Conditions: Huntington Disease
Intervention: Protocol Intervention Group
December 19, 2018
2889
NCT02360527
Completed
Completed
Retinal Neurodegeneration in Type 2 Diabetes as Biomarker for Alzheimer´s Disease
Conditions: Retinal Neurodegeneration; Alzheimer´s Disease; Type 2 Diabetes
Conditions: Retinal Neurodegeneration; Alzheimer´s Disease; Type 2 Diabetes
April 11, 2017
2890
NCT00024531
Completed
Completed
Lipitor as a Treatment for Alzheimer's Disease
Conditions: Alzheimer Disease
Intervention: Atorvastatin Calcium
Conditions: Alzheimer Disease
Intervention: Atorvastatin Calcium
November 8, 2006
2891
NCT00021723
Terminated
Terminated
Randomized Safety, Tolerability and Pilot Efficacy of AN-1792 in Alzheimer's Disease
Conditions: Alzheimer's Disease
Intervention: AN-1792 Also Known As AIP-001
Conditions: Alzheimer's Disease
Intervention: AN-1792 Also Known As AIP-001
September 22, 2009
2892
NCT00018473
Completed
Completed
Gene-Environment Interactions in Alzheimer's Disease
Conditions: Alzheimer's Disease
Conditions: Alzheimer's Disease
January 20, 2009
2893
NCT00018382
Completed
Completed
Insulin, Neurogenetics and Memory in Alzheimer's Disease
Conditions: Alzheimer Disease
Conditions: Alzheimer Disease
January 20, 2009
2894
NCT00018343
Completed
Completed
Alzheimer's Disease and Aging: Therapeutic Potential of Estrogen
Conditions: Alzheimer's Disease
Intervention: Estrogen
Conditions: Alzheimer's Disease
Intervention: Estrogen
January 20, 2009
2895
NCT00018278
Completed
Completed
Electrophysiologic Measures of Treatment Response in Alzheimer Disease
Conditions: Alzheimer Disease
Conditions: Alzheimer Disease
January 20, 2009
2896
NCT03344601
Active, not recruiting
Active, not recruiting
PHysical Activity and Exercise Outcomes in Huntington's Disease
Conditions: Huntington Disease
Intervention: Physical Activity
Conditions: Huntington Disease
Intervention: Physical Activity
November 4, 2019
2897
NCT00017940
Completed
Completed
Gene Therapy for Alzheimer's Disease Clinical Trial
Conditions: Alzheimer Disease
Intervention: Human Nerve Growth Factor
Conditions: Alzheimer Disease
Intervention: Human Nerve Growth Factor
December 10, 2009
2898
NCT03342053
Completed
Completed
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RO7234292 (ISIS 443139) in Huntington's Disease Patients Who Participated in Prior Investigational Studies of RO7234292 (ISIS 443139)
Conditions: Huntington's Disease
Intervention: RO7234292 (RG6042)
Conditions: Huntington's Disease
Intervention: RO7234292 (RG6042)
November 12, 2019
2899
NCT03306888
Completed
Completed
Feasibility and Acceptability of Implementing a Clinic-based Physical Activity Coaching Intervention in People With Premanifest and Early Stage HD
Conditions: Huntington's Disease
Conditions: Huntington's Disease
May 29, 2019
2900
NCT03296176
Unknown status
Unknown status
Metabolomic Study in Huntington's Disease (METABO-HD)
Conditions: Huntington Disease
Intervention: Blood Sample
Conditions: Huntington Disease
Intervention: Blood Sample
October 30, 2017
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Last Updated
The last updated date is the most recent date when changes to a clinical trial were
submitted to ClinicalTrials.gov. There is often a delay of a few days before the
updated trial is available on the clinical trials website.
Specify a From date to find the most recently changed trials. Specify both From and To dates to find trials changed during a certain period. If no dates are given, all trials will be included.
Dates should be given in a MM/DD/YYYY format, as in 1/1/2006 or 8/17/2004.
Specify a From date to find the most recently changed trials. Specify both From and To dates to find trials changed during a certain period. If no dates are given, all trials will be included.
Dates should be given in a MM/DD/YYYY format, as in 1/1/2006 or 8/17/2004.
First Received
The first received date is the date when the clinical trial was first submitted
to ClinicalTrials.gov. There is often a delay of a few days before the
trial is available on the clinical trials website.
Clinical trial records are often updated after they have been published. The first received, last updated, start, and end dates are all displayed in the full text view of the clinical trial.
Specify a From date to find the most recent trials. Specify both From and To dates to find trials submitted during a certain period. If no dates are given, all trials will be included.
Dates should be given in a MM/DD/YYYY format, as in 1/1/2006 or 8/17/2004.
Clinical trial records are often updated after they have been published. The first received, last updated, start, and end dates are all displayed in the full text view of the clinical trial.
Specify a From date to find the most recent trials. Specify both From and To dates to find trials submitted during a certain period. If no dates are given, all trials will be included.
Dates should be given in a MM/DD/YYYY format, as in 1/1/2006 or 8/17/2004.
Safety Issue
If selected, restricts search results to those studies which have
an outcome measure designated as a safety issue. Note that this is a
poor estimate of the safety of a treatment or intervention, but it is
all we have now.
Funded By
Studies are supported by one or more organizations called sponsors.
Support includes contributions of facilities, expertise, and/or financial resources.
All sponsors in the database have been assigned one of the following organization types:
National Institutes of Health (NIH)
Other U.S. Federal Agency - Food and Drug Administration (FDA), Centers for Disease Control and Prevention (CDC), Department of Veterans Affairs (VA), etc.
Industry - the pharmaceutical companies
University/Organization - all others, including community-based organizations
Click the check box to the left of each organization type that you wish to include in your search. You can select more than one organization type. If you do not select any type, all types will be included.
National Institutes of Health (NIH)
Other U.S. Federal Agency - Food and Drug Administration (FDA), Centers for Disease Control and Prevention (CDC), Department of Veterans Affairs (VA), etc.
Industry - the pharmaceutical companies
University/Organization - all others, including community-based organizations
Click the check box to the left of each organization type that you wish to include in your search. You can select more than one organization type. If you do not select any type, all types will be included.
Study Phase
Click the check box to the left of each study phase that you wish to include in your search. You can select more than one study phase. If you do not select a any phase, all phases will be included.
Most clinical trials are designated as phase 1, 2, 3, or 4, based on the type of questions
that study is seeking to answer:
In Phase 1 (Phase I) clinical trials, researchers test a new drug or treatment in a small group of people (20-80) for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
In Phase 2 (Phase II) clinical trials, the study drug or treatment is given to a larger group of people (100-300) to see if it is effective and to further evaluate its safety.
In Phase 3 (Phase III) clinical trials, the study drug or treatment is given to large groups of people (1,000-3,000) to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
In Phase 4 (Phase IV) clinical trials, post marketing studies delineate additional information including the drug's risks, benefits, and optimal use.
These phases are defined by the Food and Drug Administration in the Code of Federal Regulations.
In Phase 1 (Phase I) clinical trials, researchers test a new drug or treatment in a small group of people (20-80) for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
In Phase 2 (Phase II) clinical trials, the study drug or treatment is given to a larger group of people (100-300) to see if it is effective and to further evaluate its safety.
In Phase 3 (Phase III) clinical trials, the study drug or treatment is given to large groups of people (1,000-3,000) to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
In Phase 4 (Phase IV) clinical trials, post marketing studies delineate additional information including the drug's risks, benefits, and optimal use.
These phases are defined by the Food and Drug Administration in the Code of Federal Regulations.
Click the check box to the left of each study phase that you wish to include in your search. You can select more than one study phase. If you do not select a any phase, all phases will be included.
Age Group
Studies may be designed for participants of particular ages:
Children (birth-17 yrs old)
Adults (18-65 yrs old)
Senior (66+ yrs old)
Click the check box to the left of each age group that you wish to include in your search. You can select more than one age group. If you do not select a any group, all groups will be included.
Children (birth-17 yrs old)
Adults (18-65 yrs old)
Senior (66+ yrs old)
Click the check box to the left of each age group that you wish to include in your search. You can select more than one age group. If you do not select a any group, all groups will be included.
Gender
Searches can be restricted to studies which accept female or male participants.
Location Terms
If you are interested in a specific city (such as Los Angeles) or facility
name (such as the Mayo Clinic), enter it as a location term. Not all studies
include this level of detail, but if they do, this will find them.
Countries and States
Trials are often conducted at many locations around the world.
Select up to three locations to find trials conducted in
specific countries. Some countries (currently limited to the
United States, Canada, and Australia), locations can be narrowed
further by selecting a state.
Study IDs
Each trial is assigned one or more identification numbers by the institute, agency,
or organization sponsoring the trial. In addition, clinical trials assigns a
unique NCT identifier of the form NCTxxxxxxxx where each x is a numeric digit.
Use this box to search for a trial by NCT identifier or any other study
identification numbers.
Examples:
Examples:
NCT00001789
97-h-0197
ia0006
actg 076
97-h-0197
ia0006
actg 076
Sponsor (Lead)
Use this box to specify the name of an institute, organization, or company that is
conducting a trial.
It is common for several organizations to collaborate by providing funding, facilities, experimental treatments, etc. Which organization is considered the sponsor is decided by the data provider.
A search in this area will check only the sponsor field. To also look for collaborators, use the Sponsor/Collaborators search box.
When the Exact Match checkbox is checked, the sponsor name in the study must exactly match the sponsor name in the search. For example, if unchecked, a search for Merck in the lead sponsor field will find Merck, Merck KGaA, Dupont Merck, and Merck Sharp & Dohme. When checked, only Merck, with no other words in the name, will be found.
Examples:
National Cancer Institute
Mayo Clinic
Bristol-Myers Squibb
It is common for several organizations to collaborate by providing funding, facilities, experimental treatments, etc. Which organization is considered the sponsor is decided by the data provider.
A search in this area will check only the sponsor field. To also look for collaborators, use the Sponsor/Collaborators search box.
When the Exact Match checkbox is checked, the sponsor name in the study must exactly match the sponsor name in the search. For example, if unchecked, a search for Merck in the lead sponsor field will find Merck, Merck KGaA, Dupont Merck, and Merck Sharp & Dohme. When checked, only Merck, with no other words in the name, will be found.
Examples:
National Cancer Institute
Mayo Clinic
Bristol-Myers Squibb
Sponsor/Collaborators
Use this box to specify institutes, organizations, or companies that are
conducting or otherwise supporting a trial.
It is common for several organizations to collaborate by providing funding, facilities, experimental treatments, etc. Which organization is considered the sponsor is decided by the data provider.
Searching this area will look in both the sponsor field and in the collaborators field. To only look in the sponsor field, use the Sponsor (Lead) search box.
When the Exact Match checkbox is checked, the name in the study must exactly match the name in the search. For example, if unchecked, a search for Merck will find Merck, Merck KGaA, Dupont Merck, and Merck Sharp & Dohme. When checked, only Merck, with no other words in the name, will be found.
Examples:
National Cancer Institute
Mayo Clinic
Bristol-Myers Squibb
It is common for several organizations to collaborate by providing funding, facilities, experimental treatments, etc. Which organization is considered the sponsor is decided by the data provider.
Searching this area will look in both the sponsor field and in the collaborators field. To only look in the sponsor field, use the Sponsor (Lead) search box.
When the Exact Match checkbox is checked, the name in the study must exactly match the name in the search. For example, if unchecked, a search for Merck will find Merck, Merck KGaA, Dupont Merck, and Merck Sharp & Dohme. When checked, only Merck, with no other words in the name, will be found.
Examples:
National Cancer Institute
Mayo Clinic
Bristol-Myers Squibb
Outcome Measures
Use this box to specify an outcome measure used to evaluate trial results.
Examples:
weight loss
heart failure
suicide
Outcome measures are used to evaluate trial results. For example, an obesity treatment
might be evaluated by a measure of weight loss after 6 months. Measures can also be used
to quantify side effects, such as number of myocardial infarctions,
number of patients with heart arrhythmia, number of suicides, etc.
Use this box to specify an outcome measure used to evaluate trial results.
Examples:
weight loss
heart failure
suicide
Interventions
Use this box to specify drugs, devices, procedures, or vaccines used in a trial.
Examples:
clofibrate
cyclosporine
vitamin e
Interventions refer to the drug, vaccine, procedure, device, or other potential treatment being studied.
Interventions can also include less intrusive possibilities such as surveys, education, and interviews.
Use this box to specify drugs, devices, procedures, or vaccines used in a trial.
Examples:
clofibrate
cyclosporine
vitamin e
Conditions
Use this box to specify the conditions being studied.
Examples:
lupus
heart attack
leukemia
risk factors for breast cancer
Conditions usually refer to a disease, disorder, syndrome, illness, or injury. In ClinicalTrials.gov,
conditions include any health issue worth studying, such as lifespan, quality of life, health risks, etc.
Use this box to specify the conditions being studied.
Examples:
lupus
heart attack
leukemia
risk factors for breast cancer
Study Type
There are three types of studies available in ClinicalTrials.gov:
There are three types of studies available in ClinicalTrials.gov:
Interventional:
Observational:
Expanded Access:
Studies where individuals are assigned to receive specific interventions.
Participants may receive diagnostic, therapeutic or other types of interventions.
Assignment of the intervention may or may not be random.
Individuals are tracked and biomedical and/or health outcomes are assessed.
Observational:
Studies without an intervention.
Studies where biomedical and/or health outcomes are assessed in a pre-defined group of individuals.
Participants may receive diagnostic, therapeutic, or other interventions, but the investigator
does not assign specific interventions to the participants of the study.
Expanded Access:
Records describing the procedure for obtaining an experimental drug or device for patients who
are failing on currently available treatments for their condition and also are unable to
participate in ongoing clinical trials. Expanded Access records are used to register all
types of non-protocol access to experimental treatments, including protocol exception,
single-patient IND, treatment IND, compassionate use, emergency use, continued access and parallel track.
Study Results
Searches can be restricted to studies with or without results.
The inclusion of study results is a relatively new feature of ClinicalTrials.gov. Collection of results began in September of 2008. Almost all older studies and some newer studies do not include results. As time goes on, there will be more results available.
The inclusion of study results is a relatively new feature of ClinicalTrials.gov. Collection of results began in September of 2008. Almost all older studies and some newer studies do not include results. As time goes on, there will be more results available.
Recruitment Status
Also known as Enrollment Status.
Not all clinical trials in this database are accepting new participants. If you are looking for studies that are currently recruiting participants, will be recruiting in the future, or are about drugs that are available for expanded access, select Open Studies in the recruitment menu.
If you are interested in all trials, whether they are recruiting new participants or not, leave the menu with All Studies selected.
Trials may not be recruiting because they are full, completed, or halted for various reasons. In addition, some trials have very restrictive eligibility requirements and must seek participants by invitation only. To see these studies, Select Closed Studies in the recruitment menu.
Full list of all possible recruitment status values:
Open recruitment status values:
Closed recruitment status values:
Values are color coded (as shown) in the search results.
Not all clinical trials in this database are accepting new participants. If you are looking for studies that are currently recruiting participants, will be recruiting in the future, or are about drugs that are available for expanded access, select Open Studies in the recruitment menu.
If you are interested in all trials, whether they are recruiting new participants or not, leave the menu with All Studies selected.
Trials may not be recruiting because they are full, completed, or halted for various reasons. In addition, some trials have very restrictive eligibility requirements and must seek participants by invitation only. To see these studies, Select Closed Studies in the recruitment menu.
Full list of all possible recruitment status values:
Open recruitment status values:
Recruiting,
Not yet recruiting, or
Available for expanded access.
Not yet recruiting, or
Available for expanded access.
Closed recruitment status values:
Active, not recruiting,
Completed,
Terminated,
Suspended,
Withdrawn,
Enrolling by invitation,
Temporarily not available for expanded access,
No longer available for expanded access,
Approved for marketing, or
Unknown.
Completed,
Terminated,
Suspended,
Withdrawn,
Enrolling by invitation,
Temporarily not available for expanded access,
No longer available for expanded access,
Approved for marketing, or
Unknown.
Search Terms
Use this box to specify general search terms found anywhere in the trial record.
Multiple terms can be separated by an AND (all uppercase).
Examples:
type ii diabetes
veterans affairs medical center
heart attacks in older adults
nhlbi AND heart disease
Cisplatin AND safety study
Multiple terms can be separated by an AND (all uppercase).
Examples:
type ii diabetes
veterans affairs medical center
heart attacks in older adults
nhlbi AND heart disease
Cisplatin AND safety study
Help for Searching clinical trials
Help Topics:
Basic Search:
On the Basic Search page, enter a word or word(s) that you want to use to find studies.
These may include diseases, interventions, and/or locations.
Medical terms are often several words long, such as Percutaneous Coronary Intervention. To only find studies where the words are together as a phrase, put the term in quotes (e.g., "Percutaneous Coronary Intervention"). If you search for a multi-word term without quotes, studies with all words together as a phrase will appear higher in the results list than studies where the words are separated and spread throughout the document. For example, a search for Heart Attack will list a study about,
A search for "Heart Attack" would not find the second study. Synonyms are known for some terms and are used where possible. For example, a search for Heart Attack will also find occurrences of Myocardial Infarction.
Medical terms are often several words long, such as Percutaneous Coronary Intervention. To only find studies where the words are together as a phrase, put the term in quotes (e.g., "Percutaneous Coronary Intervention"). If you search for a multi-word term without quotes, studies with all words together as a phrase will appear higher in the results list than studies where the words are separated and spread throughout the document. For example, a search for Heart Attack will list a study about,
Use of a Pacemaker Following a Heart Attack.
higher than the study,
Heart Defects and Transient Ischemic Attacks
A search for "Heart Attack" would not find the second study. Synonyms are known for some terms and are used where possible. For example, a search for Heart Attack will also find occurrences of Myocardial Infarction.
Advanced Search:
Many searches are a single term and can be performed with a few words in the
search box. But, sometimes you need more control. Click on the Advanced Search tab
(if starting a new search) or Refine Search tab (if modifying an existing search)
to show additional search fields.
The additional search fields can be used to limit your search results. Note that it is not necessary to fill in all the fields, only those that are needed for your search. If you are finding too few studies, consider clearing a field and searching again.
Search Terms:
Recruitment:
Interventions:
Outcomes Measures:
Sponsor/Collaborators:
Sponsor (Lead):
Study IDs:
Country/State:
Location Terms:
Gender:
Age Group:
Phase:
Funded By:
Safety Issue:
First Received:
Last Updated:
The additional search fields can be used to limit your search results. Note that it is not necessary to fill in all the fields, only those that are needed for your search. If you are finding too few studies, consider clearing a field and searching again.
Search Terms:
Performs a general search in all sections of the study record, including title,
description, conditions, interventions, locations, etc. Terms in this field are
searched the same as Basic Search.
Recruitment:
Limits search results to studies that are open or closed. New volunteers may be
able to participate in open studies, but not closed studies.
Open recruitment status values:
Closed recruitment status values:
Values are color coded (as shown) in the search results.
Study Results:Open recruitment status values:
Recruiting,
Not yet recruiting, or
Available for expanded access.
Not yet recruiting, or
Available for expanded access.
Closed recruitment status values:
Active, not recruiting,
Completed,
Terminated,
Suspended,
Withdrawn,
Enrolling by invitation,
Temporarily not available for expanded access,
No longer available for expanded access,
Approved for marketing, or
Unknown.
Completed,
Terminated,
Suspended,
Withdrawn,
Enrolling by invitation,
Temporarily not available for expanded access,
No longer available for expanded access,
Approved for marketing, or
Unknown.
Values are color coded (as shown) in the search results.
Limits search results based on whether the study has results or not:
Study Type:
All Studies,
Studies With Results, or
Studies Without Results
The inclusion of Study Results is a new feature of ClinicalTrials.gov.
Only a few studies have results available.Studies With Results, or
Studies Without Results
Limits search results to any of the following study types:
Conditions:
Interventional,
Observational, or
Expanded Access
Observational, or
Expanded Access
Performs a search on fields describing the diseases or conditions being studied.
Interventions:
Performs a search on fields listing the drugs or interventions being studied.
Outcomes Measures:
Performs a search on fields listing the outcome measures used to quantify study results.
Sponsor/Collaborators:
Performs a search on fields listing the sponsor and collaborators of a study.
When the Exact Match checkbox is checked, the sponsor/collaborator name in the study must exactly match the name in the search. For example, if unchecked, a search for Merck in the sponsor/collaborator field will find Merck, Merck KGaA, Dupont Merck, and Merck Sharp & Dohme. When checked, only Merck, with no other words in the name, will be found.
When the Exact Match checkbox is checked, the sponsor/collaborator name in the study must exactly match the name in the search. For example, if unchecked, a search for Merck in the sponsor/collaborator field will find Merck, Merck KGaA, Dupont Merck, and Merck Sharp & Dohme. When checked, only Merck, with no other words in the name, will be found.
Sponsor (Lead):
Performs a search on the sponsor field of a study.
It is common for several organizations to collaborate by providing funding, facilities, experimental treatments, etc. Which organization is considered the "sponsor" is decided by the data provider.
When the Exact Match checkbox is checked, the lead sponsor name in the study must exactly match the lead sponsor name in the search. For example, if unchecked, a search for Merck in the lead sponsor field will find Merck, Merck KGaA, Dupont Merck, and Merck Sharp & Dohme. When checked, only Merck, with no other words in the name, will be found.
It is common for several organizations to collaborate by providing funding, facilities, experimental treatments, etc. Which organization is considered the "sponsor" is decided by the data provider.
When the Exact Match checkbox is checked, the lead sponsor name in the study must exactly match the lead sponsor name in the search. For example, if unchecked, a search for Merck in the lead sponsor field will find Merck, Merck KGaA, Dupont Merck, and Merck Sharp & Dohme. When checked, only Merck, with no other words in the name, will be found.
Study IDs:
Performs a search on fields listing ID numbers.
Country/State:
Trials are often conducted at many locations around the world.
Select up to three locations to find trials conducted in
specific countries. Some countries (currently limited to the
United States, Canada, and Australia), locations can be narrowed
further by selecting a state (e.g., United States, Alabama).
Location Terms:
Finds studies in specific locations such as a city (Los Angeles) or facility (Mayo Clinic).
Not all studies include this level of detail, but if they do, this will find them.
Gender:
Limits search results to those studies that accept female or male participants.
Age Group:
Limits search results to those studies that include at least one of the specified age
ranges. More than one age group can be selected.
Phase:
Limits search results to studies that are labeled with at least one of the specified
phases. More than one Phase can be selected.
Funded By:
Limits search results to studies that have at least one sponsor of the specified types.
More than one sponsor type can be selected.
Safety Issue:
Limits search results to studies that have at least one outcome measure designated as a safety issue.
First Received:
Limits search results to studies that were received by clinical trials within a
specified date range. The "From" or "To" field can be left blank.
Last Updated:
Limits search results to studies that were modified within a
specified date range. The "From" or "To" field can be left blank.
Refine Search:
Searches display a list of studies found (List Results tab). If you are not content with
the search results, click on the Refine Search tab at the top of the list to modify your
search.
Add terms to empty fields to search within your current result. You can also add terms to fields that contain terms. For best results, use an AND (all upper case) as a separator between terms in the same field.
For example:
When you are done making changes, click Search to display the new results.
Add terms to empty fields to search within your current result. You can also add terms to fields that contain terms. For best results, use an AND (all upper case) as a separator between terms in the same field.
For example:
heart attack
heart attack AND aspirin
heart attack AND aspirin AND older adults
heart attack AND aspirin AND older adults AND California
heart attack AND aspirin
heart attack AND aspirin AND older adults
heart attack AND aspirin AND older adults AND California
When you are done making changes, click Search to display the new results.
Search Expressions:
Use AND (all upper case) to find study records that contain all terms connected by AND.
For example:
Use OR (all upper case) to find study records that contain either term connected by OR.
For example:
Use NOT (all upper case) to find study records that do not contain the term following NOT.
For example:
Likewise, AND, OR, NOT, and parentheses can be used to create more complicated search expressions.
For example:
Note that the use of AND and OR as logical operators can be confusing.
An appropriate search for a list such as,
To search for AND as a word, instead of using it as an operator, put it in quotes.
Likewise, you can quote OR, NOT, and parentheses.
For example:
prostate cancer AND radiation
heart disease AND stroke AND California
heart disease AND stroke AND California
Use OR (all upper case) to find study records that contain either term connected by OR.
For example:
Aspirin OR ibuprofen
heart disease OR heart attack
heart disease OR heart attack
Use NOT (all upper case) to find study records that do not contain the term following NOT.
For example:
Immunodeficiency NOT AIDS
Likewise, AND, OR, NOT, and parentheses can be used to create more complicated search expressions.
For example:
prostate cancer AND NOT ( radiation OR homeopathic remedies )
( heart disease OR heart attack ) AND ( stroke OR clot )
( heart disease OR heart attack ) AND ( stroke OR clot )
Note that the use of AND and OR as logical operators can be confusing.
An appropriate search for a list such as,
Ear, Nose, and Throat Conditions
is the expression
( Ear OR Nose OR Throat ) AND Conditions
Fortunately, search will do a pretty good job of finding the right studies either way.To search for AND as a word, instead of using it as an operator, put it in quotes.
Likewise, you can quote OR, NOT, and parentheses.