Clinical Trials on Chronic Anal Fissure in United Kingdom

Total 37865 results

ECOG-ACRIN Cancer Research Group
National Cancer Institute (NCI)

Active, not recruiting

Cisplatin and Fluorouracil Compared With Carboplatin and Paclitaxel in Treating Patients With Inoperable Locally Recurrent or Metastatic Anal Cancer (InterAACT)

Anal Squamous Cell Carcinoma | Anal Basaloid Carcinoma | Anal Canal Cloacogenic Carcinoma | Metastatic Anal Canal Carcinoma | Recurrent Anal Canal Carcinoma | Stage IIIB Anal Canal Cancer | Stage IV Anal Canal Cancer

United States
S.L.A. Pharma AG

Completed

Diltiazem Hydrochloride Cream for Anal Fissure

Chronic Anal Fissure

United Kingdom, Spain, Bulgaria, Germany, Lithuania, Romania
Ventrus Biosciences, Inc

Completed

Efficacy and Safety Study With Diltiazem Hydrochloride Cream to Treat Anal Fissures

Chronic Anal Fissures

United States
National Cancer Institute (NCI)

Active, not recruiting

Nivolumab With or Without Ipilimumab in Treating Patients With Refractory Metastatic Anal Canal Cancer

Anal Canal Squamous Cell Carcinoma | Metastatic Anal Canal Carcinoma | Stage IV Anal Canal Cancer AJCC v6 and v7

United States, Canada
Ventrus Biosciences, Inc

Unknown

An Open-Label, Single- and Multi-Dose Pharmacokinetic (PK) Study of Oral Diltiazem and Topical Diltiazem Hydrochloride

Adult Subjects With Anal Fissures.

United States
ECOG-ACRIN Cancer Research Group
National Cancer Institute (NCI)

Recruiting

Lower-Dose Chemoradiation in Treating Patients With Early-Stage Anal Cancer, the DECREASE Study

Anal Basaloid Carcinoma | Anal Canal Cloacogenic Carcinoma | Anal Canal Squamous Cell Carcinoma | Anal Margin Squamous Cell Carcinoma | Stage I Anal Cancer AJCC v8 | Stage IIA Anal Cancer AJCC v8

United States
Fred Hutchinson Cancer Center
National Cancer Institute (NCI)

Terminated

HPV Vaccine Therapy in Interrupting Progression in Patients With High-Grade Vulvar or Anal Lesions

High Grade Anal Canal Intraepithelial Neoplasia | High Grade Vulvar Squamous Intraepithelial Lesion

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Completed

Linear Energy Transfer (LET)-Optimized Intensity Modulated Proton Therapy (IMPT) as a Component of Definitive Chemoradiation for Newly Diagnosed Squamous Cell Carcinoma of the Anal Canal: a Feasibility Trial

Stage III Anal Cancer AJCC v8 | Anal Canal Squamous Cell Carcinoma | Stage IIB Anal Cancer AJCC v8 | Stage IIIA Anal Cancer AJCC v8 | Stage IIIB Anal Cancer AJCC v8 | Stage IIIC Anal Cancer AJCC v8 | Stage I Anal Cancer AJCC v8 | Stage II Anal Cancer AJCC v8 | Stage IIA Anal Cancer AJCC v8

United States
London North West Healthcare NHS Trust

Recruiting

CArE for OAsI Study: Care Pathways and Anorectal Evaluation for OASI Associated Incontinence (CArE for OAsI)

Anal Incontinence | Faecal Incontinence | Follow-up | Biofeedback | Obstetric Anal Sphincter Injury | Urogynaecology | Urgency | Severe Perineal Trauma | Grade 3 Perineal Tear | Grade 4 Perineal Tear | Deferral Time | Pathways | Review | Endo-anal Ultrasound

United Kingdom
Lewisham and Greenwich NHS Trust

Completed

Diagnosis of Obstetric Anal Sphincter Injuries (OASIs) Using Transperineal Ultrasound Scan (TPUS)

Obstetric Anal Sphincter Injury

United Kingdom
Cardiff University

Recruiting

Phase 1b/II Trial of Pembrolizumab Plus IMRT in Stage III/IV Carcinoma of Anus (CORINTH)

Anal Cancer Stage III A | Anal Cancer Stage III B

United Kingdom, Norway
Massachusetts General Hospital
National Cancer Institute (NCI)

Unknown

Concurrent Chemoradiation + 5-FU + Mitomycin-C in Anal Carcinoma

Carcinoma of the Anal Canal

United States
London North West Healthcare NHS Trust

Completed

Primary Repair of Obstetric Anal Sphincter Injuries (OASIS) by Surgeons (PROS Study) (PROS)

Obstetric Anal Sphincter Injury

United Kingdom
Incyte Corporation

Completed

A Study of INCMGA00012 in Squamous Carcinoma of the Anal Canal Following Platinum-Based Chemotherapy (POD1UM-202)

Squamous Cell Carcinoma of Anal Canal

Spain, United Kingdom, United States, Germany, Belgium, France, Denmark, Italy, Norway
Laser Surgery Care
QIAGEN Gaithersburg, Inc

Completed

Hybrid Capture 2 Human Papiloma Virus (HPV) High-Risk Anal DNA Test

Anal Cancer | Anal Canal HPV Infection Diagnosis | Anal Dysplasia Diagnosis

United States
National Cancer Institute (NCI)

Recruiting

EA2176: Phase 3 Clinical Trial of Carboplatin and Paclitaxel +/- Nivolumab in Metastatic Anal Cancer Patients

Anal Canal Cloacogenic Carcinoma | Metastatic Anal Squamous Cell Carcinoma | Recurrent Anal Squamous Cell Carcinoma | Stage III Anal Cancer AJCC v8 | Stage IV Anal Cancer AJCC v8 | Unresectable Anal Squamous Cell Carcinoma | Anal Basaloid Squamous Cell Carcinoma

United States
AIDS Malignancy Consortium
National Cancer Institute (NCI); University of Arkansas; The Emmes Company, LLC; AIDS and Cancer Specimen Resource

Active, not recruiting

Surgery in Treating Patients With Early Stage Anal Canal or Perianal Cancer and HIV Infection

HIV Infection | Anal Squamous Cell Carcinoma | Stage 0 Anal Canal Cancer | Stage I Anal Canal Cancer

United States
National Cancer Institute (NCI)

Recruiting

Therapy Adapted for High Risk and Low Risk HIV-Associated Anal Cancer

HIV Infection | Anal Squamous Cell Carcinoma | Anal Canal Cloacogenic Carcinoma | Stage III Anal Cancer AJCC v8 | Stage III Rectal Cancer AJCC v8 | Stage II Rectal Cancer AJCC v8 | Anal Margin Squamous Cell Carcinoma | AIDS-Related Anal Carcinoma | Rectal Squamous Cell Carcinoma | Stage I Anal Cancer AJCC... and other conditions

United States
Ascopharm Groupe Novasco

Completed

Open, Multicentric Trial Evaluating the Efficacy and the Clinical Tolerance of PA0903 as Root Canal Sealer (PA0903)

Root Canal Obturation

France, United Kingdom
National Cancer Institute (NCI)
Canadian Cancer Trials Group

Active, not recruiting

Nivolumab After Combined Modality Therapy in Treating Patients With High Risk Stage II-IIIB Anal Cancer

Anal Canal Cloacogenic Carcinoma | Stage III Anal Cancer AJCC v8 | Anal Margin Squamous Cell Carcinoma | Stage IIB Anal Cancer AJCC v8 | Anal Basaloid Squamous Cell Carcinoma

United States, Canada
Imperial College London

Recruiting

Anal Cancer Risk In Women

Anal Cancer | Human Papilloma Virus | Anal Intraepithelial Neoplasia | Genital Neoplasm | Genital Cancer

United Kingdom
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Completed

4-Point Therapy Response Score With PET/CT for Anal Squamous Cell Cancer

Anal Squamous Cell Carcinoma | Stage III Anal Cancer AJCC v8 | Stage IIB Anal Cancer AJCC v8 | Stage IIIA Anal Cancer AJCC v8 | Stage IIIB Anal Cancer AJCC v8 | Stage IIIC Anal Cancer AJCC v8 | Stage I Anal Cancer AJCC v8 | Stage II Anal Cancer AJCC v8 | Stage IIA Anal Cancer AJCC v8 | Stage 0 Anal Cancer...

United States
Imperial College London

Recruiting

Anal Intraepithelial Neoplasia and Anal Squamous Cell Carcinoma

Anal Cancer | Anal Squamous Intraepithelial Neoplasia

United Kingdom
The Cleveland Clinic
Bard Ltd

Completed

Comparative Study Between Two Fecal Management Systems

Anal Erosion

United States
King's College London
Guy's and St Thomas' NHS Foundation Trust

Unknown

Prevalence of Bacteria Following Endodontic Treatment

Root Canal Infection

United Kingdom
Croydon Health Services NHS Trust

Completed

The Effect of Perineal Wound Infection on the Anal Sphincter

Anal Sphincter Injury | Obstetric Trauma | Perineal Infection | Perineum; Injury

United Kingdom
King's College London
National Health Service, United Kingdom

Enrolling by invitation

Impact of an Enhanced Sterile Protocol on Root Canal Treatment Outcome

Endodontic Disease | Root Canal Infection | Root Canal Treatment

United Kingdom
Incyte Corporation

Active, not recruiting

Carboplatin-paclitaxel With Retifanlimab or Placebo in Participants With Locally Advanced or Metastatic Squamous Cell Anal Carcinoma (POD1UM-303/InterAACT 2).

Squamous Cell Carcinoma of the Anal Canal

United States, Italy, Spain, United Kingdom, Australia, France, Germany, Sweden, Japan, Norway, Belgium, Denmark, Puerto Rico
Cambridge University Hospitals NHS Foundation Trust
The Christie NHS Foundation Trust; Bowel Disease Research Foundation

Unknown

Functional Outcomes Following Anal Cancer Treatment (FOFACT)

Anal Cancer

United Kingdom
London North West Healthcare NHS Trust

Completed

The Impact of 3D Anal Fistula Models on Patient Understanding and Decision Making (3DAF)

Fistula in Ano | Ano Fistula

United Kingdom
Anandasabapathy, Sharmila, M.D.

Terminated

Evaluation of a Low-Cost High Resolution Microendoscope for the Detection of Lower Gastrointestinal Neoplasia

Colon Polyps | Anal Dysplasia | Colonic Dysplasia

United States
Forest Laboratories

Withdrawn

Pharmacokinetic,Safety and Exploratory Efficacy of RECTIV® in Adolescents With Chronic Anal Fissure

Anal Fissure

United States
Northwestern University
Evergreen Invitational

Completed

Vaginal Electrical Stimulation for Postpartum Neuromuscular Recovery (VESPR)

Obstetric Anal Sphincter Injury | Vaginal Electrical Stimulation

United States
MC2 Therapeutics

Recruiting

The MC2-25 Cream in Subjects wITh CHronic KIdNEy Disease-aSsociated prurituS (ITCHINESS) Trial (ITCHINESS)

Chronic Kidney Disease-associated Pruritus

United Kingdom
Guy's and St Thomas' NHS Foundation Trust

Unknown

TransGrade Multimodal Neuromodulation of the Dorsal Root Ganglion Ensemble for Refractory Neuropathic Pain

Neuropathic Pain | Pain, Chronic

United Kingdom
University of California, Irvine

Completed

3-D Endoanal Ultrasound: Normative Anatomy of the Anal Sphincter in Nulliparous Females

Normal (no Known Injury) Anal Sphincter Female Anatomy

United States
Pennine Acute Hospitals NHS Trust
University of Leeds; National Institute for Health Research, United Kingdom

Completed

Developing an Activity Pacing Framework: Feasibility and Acceptability

Chronic Pain | Fibromyalgia | Chronic Low Back Pain | Chronic Fatigue Syndrome

United Kingdom
University of Oxford
Oxford University Hospitals NHS Trust

Completed

ART: Anal Squamous Cell Carcinoma: Investigation of Functional Imaging During chemoRadioTherapy (ART)

Anal Cancer

United Kingdom
Castle Biosciences Incorporated

Terminated

Prospective Validation Study for the Proprietary Rectal and Anal Cancer Protein Expression Assays

Anal Squamous Cell Carcinoma | Rectal Adenocarcinoma | Anal Adenocarcinoma

United States
Emory University

Completed

Reducing Perinatal Anal Incontinence Through Early Pelvic Floor Muscle Training: a Prospective Pilot Study

Perinatal and Postpartum Anal Incontinence

United States
University of Nottingham
Monash University; Versus Arthritis; University of Exeter; University of Aberdeen; Nuffield Trust

Recruiting

Pain at Work Toolkit in Employees With Chronic Pain (PAW)

Chronic Pain | Pain, Chronic

United Kingdom
King's College London

Unknown

Methotrexate Polyglutamates as a Marker of Clinical Response and Toxicity in the Treatment of Psoriasis (MTXPG)

Injury of Liver | Psoriasis Chronic

United Kingdom
University College, London
Medical Research Council

Completed

Zibotentan Better Renal Scleroderma Outcome Study (ZEBRA)

Chronic Kidney Disease | Scleroderma | Scleroderma Renal Crisis

United Kingdom
NHS Greater Glasgow and Clyde
Galapagos NV

Recruiting

7 Tesla MRI Brain Imaging to Decipher Filgotinib's Mode of Analgesic Action in Rheumatoid Arthritis (TEMPO)

Rheumatoid Arthritis | Pain, Chronic | Autoimmune | Inflammatory Disease | Sickness Behavior

United Kingdom
Queen Margaret University
British Kidney Patients Association

Unknown

Exercise and Vascular Function in Haemodialysis Patients

Chronic Kidney Disease Stage 5

United Kingdom
Newcastle University
Bristol-Myers Squibb; Institute of Cancer Research, United Kingdom; Newcastle-upon-Tyne... and other collaborators

Completed

Comparison of Imatinib Versus Dasatinib in Patients With Newly-diagnosed Chronic Phase Chronic Myeloid Leukaemia (SPIRIT2)

Myeloid Leukemia, Chronic, Chronic Phase

United Kingdom
Northumbria University
Newcastle-upon-Tyne Hospitals NHS Trust

Recruiting

Activity Pacing for Fatigue Management

Fatigue | Physical Activity | Self-regulation | Chronic Condition | Activity Pacing

United Kingdom
Cardiff University
Podiatry Department, Cardiff & Vale University Health Board; School of Health... and other collaborators

Unknown

Risk Factors for Foot Ulceration in the Chronic Kidney Disease (CKD) Population

Chronic Kidney Disease

United Kingdom
Manchester University NHS Foundation Trust

Completed

The Long Term Outcomes of Micronutrient Antioxidant Supplementation in Patients With Chronic Pancreatitis

Chronic Pancreatitis

United Kingdom
Affymax

Terminated

Safety of Single Doses of Peginesatide in Patients With Chronic Kidney Disease

Anemia | Chronic Kidney Disease | Chronic Renal Failure

United Kingdom

Clinical Trials on Chronic Anal Fissure in United Kingdom

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